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Autor:
Panagiota Zacharopoulou, David A. Duncan, Susanna Dunachie, Nicholas T.Y. Lim, Robert S. Paton, Craig Thompson, Ian D. Pavord, Derek C. Macallan, W J Hurt, Wentao Chen, Donal T. Skelly, P Goulder, Graham S. Ogg, Jian Luo, Wyncoll Dla., Nicholas M. Provine, Luzheng Xue, Chen Y-L., Philip Hopkins, Ali Amini, E Barnes, Matthew Edmans, Jonathan Ball, Jonathan Youngs, Anna L McNaughton, Paul Klenerman, Hannah Sharpe, Teresa Lambe, Vincent N. Miao, Oliver Sampson, Alex K. Shalek, Tihana Bicanic, Susannah Leaver
Publikováno v:
PLoS Pathogens, Vol 17, Iss 9, p e1009804 (2021)
et al. 2021, ' Identification of immune correlates of fatal outcomes in critically ill COVID-19 patients ', PLoS Pathogens, vol. 17, no. 9, e1009804 . https://doi.org/10.1371/journal.ppat.1009804
PLoS Pathogens
et al. 2021, ' Identification of immune correlates of fatal outcomes in critically ill COVID-19 patients ', PLoS Pathogens, vol. 17, no. 9, e1009804 . https://doi.org/10.1371/journal.ppat.1009804
PLoS Pathogens
Prior studies have demonstrated that immunologic dysfunction underpins severe illness in COVID-19 patients, but have lacked an in-depth analysis of the immunologic drivers of death in the most critically ill patients. We performed immunophenotyping o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b4d1affc75f71fbb1aaddb6a4c83a3de
https://doi.org/10.1371/journal.ppat.1009804
https://doi.org/10.1371/journal.ppat.1009804
Autor:
Yuya Fujita, Atsushi Kawakami, Haruki Matsumoto, Shuhei Yoshida, Jumpei Temmoku, Tomoyuki Asano, Shuzo Sato, Kohei Yokose, Eiji Suzuki, Toru Yago, Naoki Matsuoka, Makiko Yashiro-Furuya, Kiyoshi Migita, Hiroshi Watanabe
Publikováno v:
PLoS ONE
PLoS ONE, Vol 16, Iss 11, p e0260254 (2021)
PLoS ONE, Vol 16, Iss 11 (2021)
PLoS ONE, Vol 16, Iss 11, p e0260254 (2021)
PLoS ONE, Vol 16, Iss 11 (2021)
BackgroundRheumatoid arthritis (RA) is a heterogeneous inflammatory disease. Both anti-citrullinated peptide antibodies (ACPA) and inflammatory cytokines play an important role in the development of RA. The aim of this study was to investigate the as
Publikováno v:
PLoS ONE
PLoS ONE, Vol 16, Iss 10, p e0259039 (2021)
PLoS ONE, Vol 16, Iss 10 (2021)
PLoS ONE, Vol 16, Iss 10, p e0259039 (2021)
PLoS ONE, Vol 16, Iss 10 (2021)
Numerous studies have clarified that sprinters possess unique morphological characteristics of the thigh muscles compared with non-athletes. However, little evidence is available regarding the morphological differences between sprinters and rugby pla
Publikováno v:
PLoS ONE
PLoS ONE, Vol 16, Iss 10, p e0258029 (2021)
PLoS ONE, Vol 16, Iss 10, p e0258029 (2021)
Gluten-specific CD4+ T cells drive the pathogenesis of celiac disease and circulating gluten-specific T cells can be identified by staining with HLA-DQ:gluten tetramers. In this first single-cell RNA-seq study of tetramer-sorted T cells from untreate
Autor:
Siva Sai Krovvidi, Ramakrishna Vankayalapati, Vijaya Lakshmi Valluri, Venkata Sanjeev Kumar Neela, Kamakshi Prudhula Devalraju
Publikováno v:
PLoS ONE
PLoS ONE, Vol 16, Iss 9, p e0257185 (2021)
PLoS ONE, Vol 16, Iss 9, p e0257185 (2021)
PurposeTuberculosis (TB) is the leading cause of infectious disease related mortality, and only 10% of the infected individuals develop active disease. The likelihood of progression of latent tuberculosis infection (LTBI) to active TB disease is high
Publikováno v:
PLoS Pathogens
PLoS Pathogens, Vol 17, Iss 9, p e1009631 (2021)
PLoS Pathogens, Vol 17, Iss 9, p e1009631 (2021)
Herpes simplex virus 1 (HSV1) infects the stratified epithelia of the epidermis, oral or genital mucosa, where the main cell type is the keratinocyte. Here we have used nTERT human keratinocytes to generate a CRISPR-Cas9 knockout (KO) of the primary
Publikováno v:
PLoS ONE
PLoS ONE, Vol 16, Iss 8 (2021)
PLoS ONE, Vol 16, Iss 8, p e0255639 (2021)
PLoS ONE, Vol 16, Iss 8 (2021)
PLoS ONE, Vol 16, Iss 8, p e0255639 (2021)
This study was aimed at exploring whether latent tuberculosis infection (LTBI) contributes to the pathogenesis of immune-mediated inflammatory diseases in a TB endemic setting. We screened 198 rheumatoid arthritis (RA) patients with tuberculin skin t
Autor:
Deanna M. Santer, Shokrollah Elahi, Juan Jovel, Shima Shahbaz, Garett Dunsmore, Stan Houston, Paige Lacy, Eliana Perez Rosero
Publikováno v:
PLoS Biology
PLoS Biology, Vol 19, Iss 8, p e3001387 (2021)
PLoS Biology, Vol 19, Iss 8, p e3001387 (2021)
The interaction of neutrophils with T cells has been the subject of debate and controversies. Previous studies have suggested that neutrophils may suppress or activate T cells. Despite these studies, the interaction between neutrophils and T cells ha
Autor:
Jean-François Eléouët, Ralph A. Schmid, Quentin Haas, Artur Summerfield, Kemal Mehinagic, Beatrice Zumkehr, Sean R R Hall, Nicolas Ruggli, B. Oliveira Esteves, Melanie Brügger, Marie-Anne Rameix-Welti, Thomas Démoulins, Thomas M. Marti, Ueli Moehrlen, Horst Posthaus, A. Schogler, G. T. Barut, Marco P. Alves
Publikováno v:
PLoS Pathogens
PLoS Pathogens, Public Library of Science, 2021, 17 (7), pp.e1009789. ⟨10.1371/journal.ppat.1009789⟩
PLoS Pathogens, Public Library of Science, 2021, 17 (7), pp.1-28. ⟨10.1371/journal.ppat.1009789⟩
PLoS Pathogens, 2021, 17 (7), pp.1-28. ⟨10.1371/journal.ppat.1009789⟩
PLoS Pathogens, Vol 17, Iss 7, p e1009789 (2021)
Brügger, Melanie; Démoulins, Thomas; Barut, G. Tuba; Zumkehr, Beatrice; Oliveira Esteves, Blandina I.; Mehinagic, Kemal; Haas, Quentin; Schögler, Aline; Rameix-Welti, Marie-Anne; Eléouët, Jean-François; Moehrlen, Ueli; Marti, Thomas M.; Schmid, Ralph A.; Summerfield, Artur; Posthaus, Horst; Ruggli, Nicolas; Hall, Sean R. R.; Alves, Marco P. (2021). Pulmonary mesenchymal stem cells are engaged in distinct steps of host response to respiratory syncytial virus infection. PLoS pathogens, 17(7), e1009789. Public Library of Science 10.1371/journal.ppat.1009789
PLoS Pathogens, Public Library of Science, 2021, 17 (7), pp.e1009789. ⟨10.1371/journal.ppat.1009789⟩
PLoS Pathogens, Public Library of Science, 2021, 17 (7), pp.1-28. ⟨10.1371/journal.ppat.1009789⟩
PLoS Pathogens, 2021, 17 (7), pp.1-28. ⟨10.1371/journal.ppat.1009789⟩
PLoS Pathogens, Vol 17, Iss 7, p e1009789 (2021)
Brügger, Melanie; Démoulins, Thomas; Barut, G. Tuba; Zumkehr, Beatrice; Oliveira Esteves, Blandina I.; Mehinagic, Kemal; Haas, Quentin; Schögler, Aline; Rameix-Welti, Marie-Anne; Eléouët, Jean-François; Moehrlen, Ueli; Marti, Thomas M.; Schmid, Ralph A.; Summerfield, Artur; Posthaus, Horst; Ruggli, Nicolas; Hall, Sean R. R.; Alves, Marco P. (2021). Pulmonary mesenchymal stem cells are engaged in distinct steps of host response to respiratory syncytial virus infection. PLoS pathogens, 17(7), e1009789. Public Library of Science 10.1371/journal.ppat.1009789
Lung-resident (LR) mesenchymal stem and stromal cells (MSCs) are key elements of the alveolar niche and fundamental regulators of homeostasis and regeneration. We interrogated their function during virus-induced lung injury using the highly prevalent
Publikováno v:
PLoS ONE
PLoS ONE, Vol 16, Iss 7, p e0254783 (2021)
PLoS ONE, Vol 16, Iss 7, p e0254783 (2021)
An array of isoforms of the nuclear estrogen receptor alpha (ER-α) protein contribute to heterogeneous response in breast cancer (BCa); yet, a single-cell analysis tool that distinguishes the full-length ER-α66 protein from the activation function-