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Publikováno v:
PLoS ONE
PLoS ONE, Vol 9, Iss 6, p e97911 (2014)
PLoS ONE, Vol 16, Iss 5, p e0252177 (2021)
PLoS ONE, Vol 9, Iss 6, p e97911 (2014)
PLoS ONE, Vol 16, Iss 5, p e0252177 (2021)
The present study includes cloning and expression of recombinant Leishmania donovani histone proteins (rLdH2B, rLdH3, rLdH2A and rLdH4), assessment of their immunogenicity in Leishmania infected cured patients/endemic contacts as well as in cured ham
Publikováno v:
PLoS ONE
PLoS ONE, Vol 15, Iss 9, p e0238784 (2020)
PLoS ONE, Vol 15, Iss 9 (2020)
PLoS ONE, Vol 15, Iss 9, p e0238784 (2020)
PLoS ONE, Vol 15, Iss 9 (2020)
Apela, a novel endogenous peptide ligand for the G-protein-coupled apelin receptor, was first discovered and identified in human embryonic stem cells in 2013. Apela has showed some biological functions in promoting angiogenesis and inducing vasodilat
Publikováno v:
PLoS ONE
PLoS ONE, Vol 15, Iss 9 (2020)
PLoS ONE, Vol 15, Iss 9, p e0238184 (2020)
PLoS ONE, Vol 15, Iss 9 (2020)
PLoS ONE, Vol 15, Iss 9, p e0238184 (2020)
Pneumocystis pneumonia (PCP) is an opportunistic and potentially life-threatening infection of AIDS patients caused by the fungus Pneumocystis jirovecii (P. jirovecii). Trimethoprim-sulfamethoxazole (TMP-SMX) is the most commonly used drug combinatio
Autor:
Susanna Ricci, Stefano De Giorgi, Elisa Lazzeri, Alice Luddi, Stefania Rossi, Paola Piomboni, Vincenzo De Leo, Gianni Pozzi
Publikováno v:
PLoS ONE
PLoS ONE, Vol 13, Iss 11, p e0207684 (2018)
PLoS ONE, Vol 13, Iss 11, p e0207684 (2018)
Background Infertility is estimated to affect approximately 9–30% of reproductive-aged couples. Several conditions involving one or both partners may contribute to infertility. The aim of this study is to evaluate the role of asymptomatic genital t
Autor:
Sufang Dong, Yanggan Wang, Zhan Yin, Jun Wan, Zhu-liang Huang, Xuedong Gan, Jie Yang, Fang Zheng, Xiaowen Chen, Guibo Song, Ming Yan, Han Mingjun, Zuhua Li
Publikováno v:
PLoS ONE
PLoS ONE, Vol 13, Iss 11, p e0206883 (2018)
PLoS ONE, Vol 13, Iss 11, p e0206883 (2018)
The alpha regulator subunit B'' of protein phosphatase 2 (PPP2R3A), a regulatory subunit of protein phosphatase 2A (PP2A), was reported to present a special subcellular localization in cardiomyocytes and elevate in non-ischemia failing hearts. PPP2R3
Publikováno v:
PLoS ONE
PLoS ONE, Vol 13, Iss 11, p e0207312 (2018)
PLoS ONE, Vol 13, Iss 11, p e0207312 (2018)
Staphylococcus epidermidis small colony variants can survive inside macrophages and their survival has been proposed as a pivotal process in the pathogenesis of biomaterial associated infections. In the present study the intracellular location of cli
Publikováno v:
PLoS ONE
PLoS ONE, Vol 13, Iss 11, p e0204081 (2018)
PLoS ONE, Vol 13, Iss 11, p e0204081 (2018)
Apical periodontitis is frequently associated with the presence of bacteria biofilm, which has an indisputable impact on the prognosis of endodontic therapy due to the high resistance to adverse environmental conditions, chemicals, and antibiotic the
Publikováno v:
PLoS ONE
PLoS ONE, Vol 13, Iss 11, p e0206459 (2018)
PLoS ONE, Vol 13, Iss 11, p e0206459 (2018)
Mycobacterium tuberculosis (M.tb) contrives intracellular abode as a strategy to combat antibody onslaught. Additionally, to thrive against hostile ambiance inside host macrophages, the pathogen inhibits phago-lysosomal fusion. Finally, to further de
Ribosome display for the rapid generation of high-affinity Zika-neutralizing single-chain antibodies
Publikováno v:
PLoS ONE
PLoS ONE, Vol 13, Iss 11, p e0205743 (2018)
PLoS ONE, Vol 13, Iss 11, p e0205743 (2018)
Background Zika virus (ZIKV) is an emerging pathogen with no approved therapeutics and only limited diagnostics available. To address this gap, six mouse single-chain antibodies (scFvs) to ZIKV envelope (E) protein were isolated rapidly and efficient
Autor:
Sara Chan, Linda Rangell, Patrick Caplazi, Valentina Romeo, Audrey Filézac de L’Etang, John B. Lowe
Publikováno v:
PLoS ONE
PLoS ONE, Vol 13, Iss 11, p e0207619 (2018)
PLoS ONE, Vol 13, Iss 11, p e0207619 (2018)
In situ analysis of biomarkers is essential for clinical diagnosis and research purposes. The increasing need to understand the molecular signature of pathologies has led to the blooming of ultrasensitive and multiplexable techniques that combine in