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Autor:
Boris Bogdanow, Markus Landthaler, Q.V. Phan, Lueder Wiebusch, Emanuel Wyler, Christian Hagemeier, F. Liu
Publikováno v:
PLoS Pathogens, Vol 18, Iss 1, p e1010193 (2022)
PLoS Pathogens
PLoS Pathogens
The chimpanzee cytomegalovirus (CCMV) is the closest relative of human CMV (HCMV). Because of the high conservation between these two species and the ability of human cells to fully support CCMV replication, CCMV holds great potential as a model syst
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef97cc76854250bbd7b6a69159f220a0
http://edoc.mdc-berlin.de/21236/1/21236oa.pdf
http://edoc.mdc-berlin.de/21236/1/21236oa.pdf
Autor:
Dimitra Alexopoulou, Konstantinos Anastassiadis, Andreas Dahl, Julian Heuberger, Qinyu Zhang, Andrea Kranz, A. Francis Stewart, Walter Birchmeier, Neha Goveas, Kathrin Arndt, Claudia Waskow
Publikováno v:
PLoS Genetics, Vol 17, Iss 12, p e1009250 (2021)
PLoS Genet. 17:e1009250 (2021)
PLoS Genetics
PLoS Genet. 17:e1009250 (2021)
PLoS Genetics
Epigenetic mechanisms are gatekeepers for the gene expression patterns that establish and maintain cellular identity in mammalian development, stem cells and adult homeostasis. Amongst many epigenetic marks, methylation of histone 3 lysine 4 (H3K4) i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f8cb389560e0390b29db3df09769a3bc
http://edoc.mdc-berlin.de/21144/1/21144oa.pdf
http://edoc.mdc-berlin.de/21144/1/21144oa.pdf
Autor:
Wuguo Deng, Han Yang, Dingbo Shi, Marc R. Gartenberg, Miao Chen, Changlin Zhang, Melinda S. Borrie, Qian Long, Haohui Sun
Publikováno v:
PLoS Genetics
PLoS Genetics, Vol 17, Iss 11, p e1009899 (2021)
PLoS Genetics, Vol 17, Iss 11, p e1009899 (2021)
The robust proliferation of cancer cells requires vastly elevated levels of protein synthesis, which relies on a steady supply of aminoacylated tRNAs. Delivery of tRNAs to the cytoplasm is a highly regulated process, but the machinery for tRNA nuclea
Autor:
Banchob Sripa, Piti Ungarreevittaya, Chadamas Sakonsinsiri, Raynoo Thanan, Chawalit Pairojkul, Prakasit Sa Ngiamwibool, Sitthichai Iamsaard, Pirawan Poosekeaw
Publikováno v:
PLoS ONE
PLoS ONE, Vol 16, Iss 11 (2021)
PLoS ONE, Vol 16, Iss 11, p e0259075 (2021)
PLoS ONE, Vol 16, Iss 11 (2021)
PLoS ONE, Vol 16, Iss 11, p e0259075 (2021)
Cholangiocarcinoma (CCA) is a group of heterogenous malignancies arising from bile duct epithelium with distinct pathological features. Adaptor proteins have implicated in cell proliferation, migration, and invasion of different cancer cells. The obj
Autor:
Shweta Tiwary, Tshering D. Lama-Sherpa, Delong Meng, Shihai Zhang, Jenna L. Jewell, Nicholas G. James, Mi Hyeon Jeong, Chase H. Melick, Adna Curukovic, Huanyu Wang, Kelly A. Servage
Publikováno v:
PLoS Genetics
PLoS Genetics, Vol 17, Iss 10, p e1009832 (2021)
PLoS Genetics, Vol 17, Iss 10, p e1009832 (2021)
The mammalian target of rapamycin complex 1 (mTORC1) senses multiple stimuli to regulate anabolic and catabolic processes. mTORC1 is typically hyperactivated in multiple human diseases such as cancer and type 2 diabetes. Extensive research has focuse
Autor:
Louise N. Reynard, Alexander D. Clark, Arthur G. Pratt, Richard Howey, Najib Naamane, Heather J. Cordell
Publikováno v:
PLoS Genetics
PLoS Genetics, Vol 17, Iss 9, p e1009811 (2021)
PLoS Genetics, Vol 17, Iss 9, p e1009811 (2021)
Bayesian networks can be used to identify possible causal relationships between variables based on their conditional dependencies and independencies, which can be particularly useful in complex biological scenarios with many measured variables. Here
Autor:
Duangdao Wichadakul, Keerati Joyjamras, Nongyao Nonpanya, Pithi Chanvorachote, Kittipong Sanookpan, Boonchoo Sritularak, Chatchai Chaotham
Publikováno v:
PLoS ONE
PLoS ONE, Vol 16, Iss 8, p e0254929 (2021)
PLoS ONE, Vol 16, Iss 8, p e0254929 (2021)
In searching for novel targeted therapeutic agents for lung cancer treatment, norcycloartocarpin from Artocarpus gomezianus was reported in this study to promisingly interacted with Akt and exerted the apoptosis induction and epithelial-to-mesenchyma
Autor:
Surapong Koonpaew, Gino Laberge, Thomas Sonea, Gwenaëlle Gavory, Marc Therrien, Gawa Bidla, Caroline Baril, Guy Sauvageau
Publikováno v:
PLoS Genetics
PLoS Genetics, Vol 17, Iss 8, p e1009730 (2021)
PLoS Genetics, Vol 17, Iss 8, p e1009730 (2021)
Acute myeloid leukemia (AML) underlies the uncontrolled accumulation of immature myeloid blasts. Several cytogenetic abnormalities have been associated with AML. Among these is the NUP98-HOXA9 (NA9) translocation that fuses the Phe-Gly repeats of nuc
Autor:
Jonathan Flint, Patrick B. Chen
Publikováno v:
PLoS Genetics
PLoS Genetics, Vol 17, Iss 7, p e1009692 (2021)
PLoS Genetics, Vol 17, Iss 7, p e1009692 (2021)
Publikováno v:
PLoS Genetics
PLoS Genetics, Vol 17, Iss 7, p e1009675 (2021)
PLoS Genetics, Vol 17, Iss 7, p e1009675 (2021)
Emerging evidence indicates that tRNA-derived small RNAs (tsRNAs) are involved in fine-tuning gene expression and become dysregulated in various cancers. We recently showed that the 22nt LeuCAG3´tsRNA from the 3´ end of tRNALeu is required for effi