Zobrazeno 1 - 10
of 126
pro vyhledávání: ''
Autor:
Christel Rousseaux, Paolo Spagnolo, Silvia Speca, Caroline Dubuquoy, Pierre Desreumaux, Philippe Chavatte
Publikováno v:
PLoS ONE
PLoS ONE, Vol 16, Iss 9, p e0257281 (2021)
PLoS ONE, Vol 16, Iss 9, p e0257281 (2021)
The development of more effective, better tolerated drug treatments for progressive pulmonary fibrosis (of which idiopathic pulmonary fibrosis is the most common and severe form) is a research priority. The peroxisome proliferator-activated receptor
Publikováno v:
PLoS ONE
PLoS ONE, Vol 16, Iss 8, p e0256299 (2021)
PLoS ONE, Vol 16, Iss 8, p e0256299 (2021)
Tamoxifen is an estrogen receptor (ER) ligand with widespread use in clinical and basic research settings. Beyond its application in treating ER-positive cancer, tamoxifen has been co-opted into a powerful approach for temporal-specific genetic alter
Autor:
Xiangfan Zhang, Alexandre Boyer, Guillaume St-Jean, Adrien Levasseur, Makoto C. Nagano, Nour Abou Nader, Derek Boerboom
Publikováno v:
PLoS ONE
PLoS ONE, Vol 16, Iss 5, p e0251911 (2021)
PLoS ONE, Vol 16, Iss 5, p e0251911 (2021)
Spermatogenesis requires that a careful balance be maintained between the self-renewal of spermatogonial stem cells (SSCs) and their commitment to the developmental pathway through which they will differentiate into spermatozoa. Recently, a series of
Publikováno v:
PLoS ONE
PLoS ONE, Vol 9, Iss 6, p e97911 (2014)
PLoS ONE, Vol 16, Iss 5, p e0252177 (2021)
PLoS ONE, Vol 9, Iss 6, p e97911 (2014)
PLoS ONE, Vol 16, Iss 5, p e0252177 (2021)
The present study includes cloning and expression of recombinant Leishmania donovani histone proteins (rLdH2B, rLdH3, rLdH2A and rLdH4), assessment of their immunogenicity in Leishmania infected cured patients/endemic contacts as well as in cured ham
Autor:
Fumio Takei, Itziar Martinez-Gonzalez, Catherine A. Steer, Laura Mathä, Hanjoo Shim, Yi Han Yin
Publikováno v:
PLoS ONE
PLoS ONE, Vol 14, Iss 3, p e0214286 (2019)
PLoS ONE, Vol 16, Iss 5, p e0252257 (2021)
PLoS ONE, Vol 14, Iss 3, p e0214286 (2019)
PLoS ONE, Vol 16, Iss 5, p e0252257 (2021)
Epidemiological studies have shown sex differences in prevalence of non-allergic asthma. Recent reports demonstrated negative effects of androgen signaling on group 2 innate lymphoid cells (ILC2s), explaining a potential mechanism behind sex bias in
Autor:
Kei Matsumoto, Taihei Suzuki, Shohei Tachibana, Hirokazu Honda, Masayuki Iyoda, Yukihiro Wada, Nobuhiro Kanazawa
Publikováno v:
PLoS ONE
PLoS ONE, Vol 16, Iss 1, p e0245340 (2021)
PLoS ONE, Vol 16, Iss 1, p e0245340 (2021)
Introduction Interleukin-34 (IL-34) shares a receptor (cFMS) with colony stimulating factor-1 (CSF-1), and these two ligands mediate macrophage proliferation. However, in contrast to CSF-1, the influence of IL-34 on tubular epithelial cells (TECs) in
Publikováno v:
PLoS ONE
PLoS ONE, Vol 9, Iss 2, p e88757 (2014)
PLoS ONE, Vol 15, Iss 10, p e0240732 (2020)
PLoS ONE, Vol 9, Iss 2, p e88757 (2014)
PLoS ONE, Vol 15, Iss 10, p e0240732 (2020)
Hmga2 protein belongs to the non-histone chromosomal high-mobility group (HMG) protein family. HMG proteins have been shown to function as architectural transcription regulators, facilitating enhanceosome formation on a variety of mammalian promoters
Autor:
Dagmara Korona, Simon J. Hubbard, Kathryn S. Lilley, Glynnis Johnson, Bertrand Fabre, Jonathan G. Lees, Michael G. Nelson, Steven Russell, Bettina Fischer, Daniel J.H. Nightingale
Publikováno v:
PLoS ONE
PLoS ONE, Vol 15, Iss 8, p e0236679 (2020)
PLoS ONE, Vol 15, Iss 8, p e0236679 (2020)
TheDrosophila shaggygene (sgg, GSK-3) encodes multiple protein isoforms with serine/threonine kinase activity and is a key player in diverse developmental signalling pathways. Currently it is unclear whether different Sgg proteoforms are similarly in
Autor:
Chris Koceja, Ramani Ramchandran, Emily Gronseth, Ling Wang, Ankan Gupta, Suresh Kumar, Raman G. Kutty, Kevin R. Rarick
Publikováno v:
PLoS ONE
PLoS ONE, Vol 15, Iss 7, p e0235852 (2020)
PLoS ONE, Vol 15, Iss 7, p e0235852 (2020)
The medulloblastoma (MB) microenvironment is diverse, and cell-cell interactions within this milieu is of prime importance. Astrocytes, a major component of the microenvironment, have been shown to impact primary tumor cell phenotypes and metastasis.
Publikováno v:
PLoS ONE
PLoS ONE, Vol 15, Iss 7, p e0236928 (2020)
PLoS ONE, Vol 15, Iss 7, p e0236928 (2020)
The rabbit retinal vein occlusion (RVO) model is an experimental system that mimics retinal ischemic diseases in humans. The rabbit RVO model is widely used to assess the therapeutic efficacy of various experimental surgical procedures. In the presen