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Publikováno v:
PLoS ONE
Dysregulation of calcium homeostasis has been hypothesized to play a role in Alzheimer’s disease (AD) pathogenesis. Increased calcium levels can impair axonal transport, disrupt synaptic transmission, and ultimately lead to cell death. Given the po
Autor:
Daniel R. Ambruso, Natalie J. Briones, Angelina F. Baroffio, John R. Murphy, Alexander D. Tran, Katherine Gowan, Bridget Sanford, Michael Ellison, Kenneth L. Jones
Publikováno v:
PLoS ONE
PLoS ONE, Vol 17, Iss 2, p e0263370 (2022)
PLoS ONE, Vol 17, Iss 2, p e0263370 (2022)
The cytokine Interferon-γ (IFN-γ) exerts powerful immunoregulatory effects on the adaptive immune system and also enhances functions of the neutrophil (PMN). The clinical use of IFN-γ has been driven by the finding that its administration to patie
Autor:
Guanghao Qin, Fang He, Hongda Zhang, Emmanuel Eric Pazo, Guangzheng Dai, Qingchi Yao, Wei He, Ling Xu, Tiezhu Lin
Publikováno v:
PLoS ONE
PLoS ONE, Vol 17, Iss 2, p e0263587 (2022)
PLoS ONE, Vol 17, Iss 2, p e0263587 (2022)
Aim To evaluate the association between the value of neutrophil to lymphocyte ratio (NLR), platelet to lymphocyte ratio (PLR), monocyte to high-density lipoprotein ratio (MHR) and the development of retinal artery occlusion (RAO) and retinal vein occ
Autor:
Sara B. Hernández, Sónia Castanheira, M. Graciela Pucciarelli, Juan J. Cestero, Gadea Rico-Pérez, Alberto Paradela, Juan A. Ayala, Sonsoles Velázquez, Ana San-Félix, Felipe Cava, Francisco García-del Portillo
Publikováno v:
Digital.CSIC. Repositorio Institucional del CSIC
instname
Biblos-e Archivo. Repositorio Institucional de la UAM
PLoS Pathogens
PLoS Pathogens, Vol 18, Iss 1, p e1010241 (2022)
instname
Biblos-e Archivo. Repositorio Institucional de la UAM
PLoS Pathogens
PLoS Pathogens, Vol 18, Iss 1, p e1010241 (2022)
Salmonella enterica causes intracellular infections that can be limited to the intestine or spread to deeper tissues. In most cases, intracellular bacteria show moderate growth. How these bacteria face host defenses that recognize peptidoglycan, is p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::926a783c26097c9cc690393d3ea8bcc6
https://hdl.handle.net/10486/700965
https://hdl.handle.net/10486/700965
Autor:
Boris Bogdanow, Markus Landthaler, Q.V. Phan, Lueder Wiebusch, Emanuel Wyler, Christian Hagemeier, F. Liu
Publikováno v:
PLoS Pathogens, Vol 18, Iss 1, p e1010193 (2022)
PLoS Pathogens
PLoS Pathogens
The chimpanzee cytomegalovirus (CCMV) is the closest relative of human CMV (HCMV). Because of the high conservation between these two species and the ability of human cells to fully support CCMV replication, CCMV holds great potential as a model syst
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef97cc76854250bbd7b6a69159f220a0
http://edoc.mdc-berlin.de/21236/1/21236oa.pdf
http://edoc.mdc-berlin.de/21236/1/21236oa.pdf
Autor:
Katie Bechman, Mark Yates, Kirsty Mann, Deepak Nagra, Laura-Jane Smith, Andy I. Rutherford, Amit Patel, Jimstan Periselneris, David Walder, Richard J. B. Dobson, Zeljko Kraljevic, James H. T. Teo, William Bernal, Richard Barker, James B. Galloway, Sam Norton
Publikováno v:
PLoS ONE
PLoS ONE, Vol 17, Iss 1, p e0261142 (2022)
PLoS ONE, Vol 17, Iss 1, p e0261142 (2022)
Background The Covid-19 pandemic in the United Kingdom has seen two waves; the first starting in March 2020 and the second in late October 2020. It is not known whether outcomes for those admitted with severe Covid were different in the first and sec
Autor:
Shoh Sasaki, Kensaku Nishihira, Atsushi Yamashita, Tomomi Fujii, Kenji Onoue, Yoshihiko Saito, Kinta Hatakeyama, Yoshisato Shibata, Yujiro Asada, Chiho Ohbayashi
Publikováno v:
PLoS ONE
PLoS ONE, Vol 17, Iss 1, p e0262413 (2022)
PLoS ONE, Vol 17, Iss 1, p e0262413 (2022)
Activation of the classical complement pathway plays a major role in regulating atherosclerosis progression, and it is believed to have both proatherogenic and atheroprotective effects. This study focused on C1q, the first protein in the classical pa
Autor:
Afam A. Okoye, Rémi Fromentin, Hiroshi Takata, Jessica H. Brehm, Yoshinori Fukazawa, Bryan Randall, Marion Pardons, Vincent Tai, Jun Tang, Jeremy Smedley, Michael Axthelm, Jeffrey D. Lifson, Louis J. Picker, David Favre, Lydie Trautmann, Nicolas Chomont
Publikováno v:
PLoS Pathogens, Vol 18, Iss 1, p e1010245 (2022)
PLoS Pathogens
PLOS PATHOGENS
PLoS Pathogens
PLOS PATHOGENS
Activation of the NF-κB signaling pathway by Protein Kinase C (PKC) agonists is a potent mechanism for human immunodeficiency virus (HIV) latency disruption in vitro. However, significant toxicity risks and the lack of evidence supporting their acti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ddf512863f7ce95b2807f95366e5642
Autor:
Abdullah M. Izmirly, Adam-Nicolas Pelletier, Jennifer Connors, Bhavani Taramangalam, Sawsan O. Alturki, Emma A. Gordon, Sana O. Alturki, Joshua C. Mell, Gokul Swaminathan, Vivin Karthik, Michele A. Kutzler, Esper G. Kallas, Rafick-Pierre Sekaly, Elias K. Haddad
Publikováno v:
PLoS Pathogens
PLoS Pathogens, Vol 18, Iss 1, p e1009903 (2022)
PLoS Pathogens, Vol 18, Iss 1, p e1009903 (2022)
It has been estimated that more than 390 million people are infected with Dengue virus every year; around 96 millions of these infections result in clinical pathologies. To date, there is only one licensed viral vector-based Dengue virus vaccine CYD-
Autor:
Dimitra Alexopoulou, Konstantinos Anastassiadis, Andreas Dahl, Julian Heuberger, Qinyu Zhang, Andrea Kranz, A. Francis Stewart, Walter Birchmeier, Neha Goveas, Kathrin Arndt, Claudia Waskow
Publikováno v:
PLoS Genetics, Vol 17, Iss 12, p e1009250 (2021)
PLoS Genet. 17:e1009250 (2021)
PLoS Genetics
PLoS Genet. 17:e1009250 (2021)
PLoS Genetics
Epigenetic mechanisms are gatekeepers for the gene expression patterns that establish and maintain cellular identity in mammalian development, stem cells and adult homeostasis. Amongst many epigenetic marks, methylation of histone 3 lysine 4 (H3K4) i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f8cb389560e0390b29db3df09769a3bc
http://edoc.mdc-berlin.de/21144/1/21144oa.pdf
http://edoc.mdc-berlin.de/21144/1/21144oa.pdf