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Autor:
Amrit P. Singh, Frank Schmitz, Adam Z. Rosenthal, Madhav V. Dhodapkar, Antje Hoering, Daisy Alapat, Yan Ren, Maurizio Zangari, Kelsie Smith, Samuel A. Danziger, Jake Gockley, Andrew Dervan, Alexander V. Ratushny, Mark McConnell, Robert M. Hershberg, Suzana Couto, Brian A Walker, Faith E. Davies, Alison Fitch, Wilbert B. Copeland, Gareth J. Morgan, Bart Barlogie, Phil Farmer, David J. Reiss, Brian Fox, Mary H. Young, Frits van Rhee, Cody Ashby, Katie Newhall, Nathan Petty, Michael A Bauer, Robert Z. Orlowski, Matthew Trotter
Publikováno v:
PLoS Medicine
PLoS Medicine, Vol 17, Iss 11, p e1003323 (2020)
PLoS Medicine, Vol 17, Iss 11, p e1003323 (2020)
Background The tumor microenvironment (TME) is increasingly appreciated as an important determinant of cancer outcome, including in multiple myeloma (MM). However, most myeloma microenvironment studies have been based on bone marrow (BM) aspirates, w
Publikováno v:
PLoS Pathogens
PLoS Pathogens, Vol 17, Iss 9, p e1009936 (2021)
PLoS Pathogens, Vol 17, Iss 9, p e1009936 (2021)
While Entamoeba histolytica (Eh)-induced pro-inflammatory responses are critical in disease pathogenesis, the downstream signaling pathways that subsequently dampens inflammation and the immune response remains unclear. Eh in contact with macrophages
Autor:
Elizaveta A. Demishkevich, Ekaterina Moiseeva, Igor Kon, Anna A. Kundalevich, Andrey Y. Zyubin, Ilia G. Samusev, Viktoria Butova, Karina Matveeva, Vladimir Rafalskiy
Publikováno v:
PLoS ONE
PLoS ONE, Vol 16, Iss 9, p e0256621 (2021)
PLoS ONE, Vol 16, Iss 9, p e0256621 (2021)
This paper describes a detailed study of spectral and time-resolved photoprocesses in human platelets and their complexes with platinum (Pt) nanoparticles (NPs). Fluorescence, quantum yield, and platelet amino acid lifetime changes in the presence an
Publikováno v:
PLoS ONE
PLoS ONE, Vol 16, Iss 9, p e0256739 (2021)
PLoS ONE, Vol 16, Iss 9, p e0256739 (2021)
Background & aims Among the multiplicity of factors involved in rising incidence of hepatocellular carcinoma (HCC)-the second deadliest cancer, late diagnosis of early-stage HCC nodules originating from late-stage cirrhotic nodules is the most crucia
Autor:
Siva Sai Krovvidi, Ramakrishna Vankayalapati, Vijaya Lakshmi Valluri, Venkata Sanjeev Kumar Neela, Kamakshi Prudhula Devalraju
Publikováno v:
PLoS ONE
PLoS ONE, Vol 16, Iss 9, p e0257185 (2021)
PLoS ONE, Vol 16, Iss 9, p e0257185 (2021)
PurposeTuberculosis (TB) is the leading cause of infectious disease related mortality, and only 10% of the infected individuals develop active disease. The likelihood of progression of latent tuberculosis infection (LTBI) to active TB disease is high
Publikováno v:
PLoS Pathogens
PLoS Pathogens, Vol 17, Iss 9, p e1009631 (2021)
PLoS Pathogens, Vol 17, Iss 9, p e1009631 (2021)
Herpes simplex virus 1 (HSV1) infects the stratified epithelia of the epidermis, oral or genital mucosa, where the main cell type is the keratinocyte. Here we have used nTERT human keratinocytes to generate a CRISPR-Cas9 knockout (KO) of the primary
Autor:
Sharon Chua, Nitish Mehta, Roomasa Channa, Paul J. Foster, Sidra Zafar, Anthony P Khawaja, Kyungmoo Lee, Christopher I. Amos, Michael D. Abràmoff, Jie Gao, Kristen A. Staggers, Praveen J Patel, Benjamin J. Frankfort, Charles G. Minard
Publikováno v:
PLoS ONE
PLoS ONE, Vol 16, Iss 9, p e0257836 (2021)
PLoS ONE, Vol 16, Iss 9, p e0257836 (2021)
Importance Efforts are underway to incorporate retinal neurodegeneration in the diabetic retinopathy severity scale. However, there is no established measure to quantify diabetic retinal neurodegeneration (DRN). Objective We compared total retinal, m
Autor:
Rômulo Eufrosino de Alencar Rodrigues, Rodrigo Pinheiro de Toledo Vianna, Adélia da Costa Pereira de Arruda Neta, José Moreira da Silva Neto, Sara Ferreira, Jevuks Matheus de Araújo, Martin O'Flaherty, Rafaela Lira Formiga Cavalcanti de Lima, Flávia Emília Leite de Lima Ferreira, Patrícia Vasconcelos Leitão Moreira
Publikováno v:
PLoS ONE
PLoS ONE, Vol 16, Iss 9, p e0253639 (2021)
PLoS ONE, Vol 16, Iss 9, p e0253639 (2021)
Objective To analyse the mortality rate trend due to coronary heart disease (CHD) and stroke in the adult population in Brazil. Methods From 2000 to 2018, a time trend study with joinpoint regression was conducted among Brazilian men and women aged 3
Autor:
Ab Rauf Shah, Bhanwar Lal Puniya, Matteo Barberis, Alyssa La Fleur, Tomáš Helikar, Kenneth Y. Wertheim
Publikováno v:
PLoS Computational Biology, Vol 17, Iss 8, p e1009209 (2021)
PLoS Computational Biology, 17(8):e1009209. Public Library of Science
PLoS Computational Biology
PLoS Computational Biology, 17(8):e1009209. Public Library of Science
PLoS Computational Biology
Immune responses rely on a complex adaptive system in which the body and infections interact at multiple scales and in different compartments. We developed a modular model of CD4+ T cells, which uses four modeling approaches to integrate processes at
Publikováno v:
PLoS ONE
PLoS ONE, Vol 16, Iss 8 (2021)
PLoS ONE, Vol 16, Iss 8, p e0255639 (2021)
PLoS ONE, Vol 16, Iss 8 (2021)
PLoS ONE, Vol 16, Iss 8, p e0255639 (2021)
This study was aimed at exploring whether latent tuberculosis infection (LTBI) contributes to the pathogenesis of immune-mediated inflammatory diseases in a TB endemic setting. We screened 198 rheumatoid arthritis (RA) patients with tuberculin skin t