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Autor:
Martin V. Hamann, Niklas Beschorner, Xuan-Khang Vu, Ilona Hauber, Ulrike C. Lange, Bjoern Traenkle, Philipp D. Kaiser, Daniel Foth, Carola Schneider, Hildegard Büning, Ulrich Rothbauer, Joachim Hauber
Publikováno v:
PLoS ONE
PLoS ONE, Vol 16, Iss 12, p e0261269 (2021)
PLoS ONE, Vol 16, Iss 12, p e0261269 (2021)
Adeno-associated viruses (AAV) are considered non-pathogenic in humans, and thus have been developed into powerful vector platforms for in vivo gene therapy. Although the various AAV serotypes display broad tropism, frequently infecting multiple tiss
Publikováno v:
PLoS ONE
PLoS ONE, Vol 16, Iss 12, p e0260774 (2021)
PLoS ONE, Vol 16, Iss 12, p e0260774 (2021)
Background & aims Platelet count/spleen longest diameter ratio (PSDR) is widely used in clinical practice due to its good performance in predicting esophageal varices (EV). We obtained spleen volume (SV) by magnetic resonance examination, the purpose
Autor:
Elif Karaaslan, Aykut Ozdarendeli, Mehmet Ziya Doymaz, Ali Osman Kiliç, Faruk Karakeçili, Merve Kalkan-Yazıcı, Nesibe Selma Çetin, Sevde Hasanoğlu, Ahmet Kalkan
Publikováno v:
PLoS Neglected Tropical Diseases
PLoS Neglected Tropical Diseases, Vol 15, Iss 12, p e0009973 (2021)
PLoS Neglected Tropical Diseases, Vol 15, Iss 12, p e0009973 (2021)
In 2019, the World Health Organization declared 3 billion to be at risk of developing Crimean Congo Hemorrhagic Fever (CCHF). The causative agent of this deadly infection is CCHFV. The data related to the biology and immunology of CCHFV are rather sc
Autor:
Brittany E. Jewell, An Xu, Dandan Zhu, Mo-Fan Huang, Linchao Lu, Mo Liu, Erica L. Underwood, Jun Hyoung Park, Huihui Fan, Julian A. Gingold, Ruoji Zhou, Jian Tu, Zijun Huo, Ying Liu, Weidong Jin, Yi-Hung Chen, Yitian Xu, Shu-Hsia Chen, Nino Rainusso, Nathaniel K. Berg, Danielle A. Bazer, Christopher Vellano, Philip Jones, Holger K. Eltzschig, Zhongming Zhao, Benny Abraham Kaipparettu, Ruiying Zhao, Lisa L. Wang, Dung-Fang Lee
Publikováno v:
PLoS Genetics
PLoS Genetics, Vol 17, Iss 12, p e1009971 (2021)
PLoS Genetics, Vol 17, Iss 12, p e1009971 (2021)
Rothmund-Thomson syndrome (RTS) is an autosomal recessive genetic disorder characterized by poikiloderma, small stature, skeletal anomalies, sparse brows/lashes, cataracts, and predisposition to cancer. Type 2 RTS patients with biallelic RECQL4 patho
Autor:
Champica K. Bodinayake, Ajith DeS Nagahawatte, Vasantha Devasiri, Niroshana J. Dahanayake, Gaya B. Wijayaratne, Nayani P. Weerasinghe, Madureka Premamali, Tianchen Sheng, Bradly P. Nicholson, Harshanie A. Ubeysekera, Ruvini MP Kurukulasooriya, Aruna D. de Silva, Truls Østbye, Christopher W. Woods, L Gayani Tillekeratne
Publikováno v:
PLoS Neglected Tropical Diseases
PLoS Neglected Tropical Diseases, Vol 15, Iss 12, p e0010091 (2021)
PLoS Neglected Tropical Diseases, Vol 15, Iss 12, p e0010091 (2021)
Background Healthcare systems in dengue-endemic countries are often overburdened due to the high number of patients hospitalized according to dengue management guidelines. We systematically evaluated clinical outcomes in a large cohort of patients ho
Publikováno v:
PLoS Pathogens
PLoS Pathogens, Vol 17, Iss 12 (2021)
PLoS Pathogens, Vol 17, Iss 12, p e1010065 (2021)
PLoS Pathogens, Vol 17, Iss 12 (2021)
PLoS Pathogens, Vol 17, Iss 12, p e1010065 (2021)
Dengue is a mosquito-borne disease caused by dengue virus (DENV), where four serotypes can infect humans. Most DENV infections are self-resolving, but in some individuals, severe dengue characterised by a sudden increase in haematocrit, rapid decreas
Autor:
Patricia Almendro-Vázquez, Rocio Laguna-Goya, Maria Ruiz-Ruigomez, Alberto Utrero-Rico, Antonio Lalueza, Guillermo Maestro de la Calle, Pilar Delgado, Luis Perez-Ordoño, Eva Muro, Juan Vila, Isabel Zamarron, Miguel Moreno-Batanero, Marta Chivite-Lacaba, Francisco Javier Gil-Etayo, Carmen Martín-Higuera, María Ángeles Meléndez-Carmona, Carlos Lumbreras, Irene Arellano, Balbino Alarcon, Luis Miguel Allende, Jose Maria Aguado, Estela Paz-Artal
Publikováno v:
PLoS Pathogens
PLoS Pathogens, Vol 17, Iss 12, p e1010211 (2021)
Digital.CSIC. Repositorio Institucional del CSIC
instname
PLoS Pathogens, Vol 17, Iss 12, p e1010211 (2021)
Digital.CSIC. Repositorio Institucional del CSIC
instname
The timing of the development of specific adaptive immunity after natural SARS-CoV-2 infection, and its relevance in clinical outcome, has not been characterized in depth. Description of the long-term maintenance of both cellular and humoral response
Autor:
Panagiota Zacharopoulou, David A. Duncan, Susanna Dunachie, Nicholas T.Y. Lim, Robert S. Paton, Craig Thompson, Ian D. Pavord, Derek C. Macallan, W J Hurt, Wentao Chen, Donal T. Skelly, P Goulder, Graham S. Ogg, Jian Luo, Wyncoll Dla., Nicholas M. Provine, Luzheng Xue, Chen Y-L., Philip Hopkins, Ali Amini, E Barnes, Matthew Edmans, Jonathan Ball, Jonathan Youngs, Anna L McNaughton, Paul Klenerman, Hannah Sharpe, Teresa Lambe, Vincent N. Miao, Oliver Sampson, Alex K. Shalek, Tihana Bicanic, Susannah Leaver
Publikováno v:
PLoS Pathogens, Vol 17, Iss 9, p e1009804 (2021)
et al. 2021, ' Identification of immune correlates of fatal outcomes in critically ill COVID-19 patients ', PLoS Pathogens, vol. 17, no. 9, e1009804 . https://doi.org/10.1371/journal.ppat.1009804
PLoS Pathogens
et al. 2021, ' Identification of immune correlates of fatal outcomes in critically ill COVID-19 patients ', PLoS Pathogens, vol. 17, no. 9, e1009804 . https://doi.org/10.1371/journal.ppat.1009804
PLoS Pathogens
Prior studies have demonstrated that immunologic dysfunction underpins severe illness in COVID-19 patients, but have lacked an in-depth analysis of the immunologic drivers of death in the most critically ill patients. We performed immunophenotyping o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b4d1affc75f71fbb1aaddb6a4c83a3de
https://doi.org/10.1371/journal.ppat.1009804
https://doi.org/10.1371/journal.ppat.1009804
Autor:
Sho Yokoyama, Takashi Kojima, Rie Horai, Hideki Nakamura, Hiroyuki Sato, Yoshiki Tanaka, Yukihito Kato, Mari Mitamura, Kazuo Ichikawa, Kiyoshi Tanaka
Publikováno v:
PLoS ONE
PLoS ONE, Vol 16, Iss 11, p e0260525 (2021)
PLoS ONE, Vol 16, Iss 11, p e0260525 (2021)
Purpose To evaluate the age-related change in color visual acuity (CVA) in normal eyes. Methods In total, 162 normal eyes (162 subjects, women: 52, men: 110, age range: 15–68 years) with best-corrected visual acuity (BCVA) ≥20/13 were enrolled. F
Publikováno v:
PLoS ONE
PLoS ONE, Vol 16, Iss 11, p e0255860 (2021)
PLoS ONE, Vol 16, Iss 11, p e0255860 (2021)
The molecular mechanisms underlying morphological diversity in retinal cell types are poorly understood. We have previously reported that several members of the Copine family of Ca-dependent membrane adaptors are expressed in Retinal Ganglion Cells a