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Publikováno v:
PLoS ONE
Dysregulation of calcium homeostasis has been hypothesized to play a role in Alzheimer’s disease (AD) pathogenesis. Increased calcium levels can impair axonal transport, disrupt synaptic transmission, and ultimately lead to cell death. Given the po
Autor:
Daniel R. Ambruso, Natalie J. Briones, Angelina F. Baroffio, John R. Murphy, Alexander D. Tran, Katherine Gowan, Bridget Sanford, Michael Ellison, Kenneth L. Jones
Publikováno v:
PLoS ONE
PLoS ONE, Vol 17, Iss 2, p e0263370 (2022)
PLoS ONE, Vol 17, Iss 2, p e0263370 (2022)
The cytokine Interferon-γ (IFN-γ) exerts powerful immunoregulatory effects on the adaptive immune system and also enhances functions of the neutrophil (PMN). The clinical use of IFN-γ has been driven by the finding that its administration to patie
Autor:
Guanghao Qin, Fang He, Hongda Zhang, Emmanuel Eric Pazo, Guangzheng Dai, Qingchi Yao, Wei He, Ling Xu, Tiezhu Lin
Publikováno v:
PLoS ONE
PLoS ONE, Vol 17, Iss 2, p e0263587 (2022)
PLoS ONE, Vol 17, Iss 2, p e0263587 (2022)
Aim To evaluate the association between the value of neutrophil to lymphocyte ratio (NLR), platelet to lymphocyte ratio (PLR), monocyte to high-density lipoprotein ratio (MHR) and the development of retinal artery occlusion (RAO) and retinal vein occ
Autor:
Katie Bechman, Mark Yates, Kirsty Mann, Deepak Nagra, Laura-Jane Smith, Andy I. Rutherford, Amit Patel, Jimstan Periselneris, David Walder, Richard J. B. Dobson, Zeljko Kraljevic, James H. T. Teo, William Bernal, Richard Barker, James B. Galloway, Sam Norton
Publikováno v:
PLoS ONE
PLoS ONE, Vol 17, Iss 1, p e0261142 (2022)
PLoS ONE, Vol 17, Iss 1, p e0261142 (2022)
Background The Covid-19 pandemic in the United Kingdom has seen two waves; the first starting in March 2020 and the second in late October 2020. It is not known whether outcomes for those admitted with severe Covid were different in the first and sec
Autor:
Shoh Sasaki, Kensaku Nishihira, Atsushi Yamashita, Tomomi Fujii, Kenji Onoue, Yoshihiko Saito, Kinta Hatakeyama, Yoshisato Shibata, Yujiro Asada, Chiho Ohbayashi
Publikováno v:
PLoS ONE
PLoS ONE, Vol 17, Iss 1, p e0262413 (2022)
PLoS ONE, Vol 17, Iss 1, p e0262413 (2022)
Activation of the classical complement pathway plays a major role in regulating atherosclerosis progression, and it is believed to have both proatherogenic and atheroprotective effects. This study focused on C1q, the first protein in the classical pa
Autor:
Juan F. Alzate, Wildeman Zapata, María Teresa Rugeles, Natalia A. Taborda, Juan C. Hernandez, Eduardo E. Zurek, Jorge A Luján, Tulio J. Lopera, Wbeimar Aguilar-Jimenez, Miguel A. Toro
Publikováno v:
PLoS ONE
PLoS ONE, Vol 16, Iss 12, p e0260729 (2021)
PLoS ONE, Vol 16, Iss 12, p e0260729 (2021)
Intestinal microbiota facilitates food breakdown for energy metabolism and influences the immune response, maintaining mucosal homeostasis. Overall, HIV infection is associated with intestinal dysbiosis and immune activation, which has been related t
Publikováno v:
PLoS ONE
PLoS ONE, Vol 16, Iss 12, p e0261138 (2021)
PLoS ONE, Vol 16, Iss 12, p e0261138 (2021)
Objective This study is to explore the correlation between the contrast-enhanced ultrasound (CEUS) characteristics of breast cancer and the epithelial-mesenchyme transformation (EMT). Methods Totally 119 patients of breast cancer underwent CEUS. Tiss
Autor:
Pål Kvello, Niklas Gericke
Publikováno v:
PLoS ONE
PLOS ONE
PLoS ONE, Vol 16, Iss 12, p e0260752 (2021)
PLOS ONE
PLoS ONE, Vol 16, Iss 12, p e0260752 (2021)
Teaching about the nervous system has become a challenging task in secondary biology and science education because of the fast development in the field of neuroscience. A major challenge is to determine what content to teach. Curricula goals are ofte
Autor:
Shubham Basu, Keith H. Baratz, Leo J. Maguire, Sanjay V. Patel, Ross A. Aleff, Michael P. Fautsch, Eric D. Wieben, Tommy A. Rinkoski
Publikováno v:
PLoS ONE
PLoS ONE, Vol 16, Iss 12, p e0260837 (2021)
PLoS ONE, Vol 16, Iss 12, p e0260837 (2021)
Expansion of CTG trinucleotide repeats (TNR) in the transcription factor 4 (TCF4) gene is highly associated with Fuchs Endothelial Corneal Dystrophy (FECD). Due to limitations in the availability of DNA from diseased corneal endothelium, sizing of CT
Publikováno v:
PLoS ONE
PLoS ONE, Vol 16, Iss 12, p e0261730 (2021)
PLoS ONE, Vol 16, Iss 12, p e0261730 (2021)
In this study we investigate how β-catenin-dependent WNT signalling impacts midbrain dopaminergic neuron (mDA) specification. mDA cultures at day 65 of differentiation responded to 25 days of the tankyrase inhibitor XAV969 (XAV, 100nM) with reduced