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Autor:
Daniel R. Ambruso, Natalie J. Briones, Angelina F. Baroffio, John R. Murphy, Alexander D. Tran, Katherine Gowan, Bridget Sanford, Michael Ellison, Kenneth L. Jones
Publikováno v:
PLoS ONE
PLoS ONE, Vol 17, Iss 2, p e0263370 (2022)
PLoS ONE, Vol 17, Iss 2, p e0263370 (2022)
The cytokine Interferon-γ (IFN-γ) exerts powerful immunoregulatory effects on the adaptive immune system and also enhances functions of the neutrophil (PMN). The clinical use of IFN-γ has been driven by the finding that its administration to patie
Autor:
Dimitra Alexopoulou, Konstantinos Anastassiadis, Andreas Dahl, Julian Heuberger, Qinyu Zhang, Andrea Kranz, A. Francis Stewart, Walter Birchmeier, Neha Goveas, Kathrin Arndt, Claudia Waskow
Publikováno v:
PLoS Genetics, Vol 17, Iss 12, p e1009250 (2021)
PLoS Genet. 17:e1009250 (2021)
PLoS Genetics
PLoS Genet. 17:e1009250 (2021)
PLoS Genetics
Epigenetic mechanisms are gatekeepers for the gene expression patterns that establish and maintain cellular identity in mammalian development, stem cells and adult homeostasis. Amongst many epigenetic marks, methylation of histone 3 lysine 4 (H3K4) i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f8cb389560e0390b29db3df09769a3bc
http://edoc.mdc-berlin.de/21144/1/21144oa.pdf
http://edoc.mdc-berlin.de/21144/1/21144oa.pdf
Publikováno v:
PLoS ONE
PLoS ONE, Vol 16, Iss 12, p e0261730 (2021)
PLoS ONE, Vol 16, Iss 12, p e0261730 (2021)
In this study we investigate how β-catenin-dependent WNT signalling impacts midbrain dopaminergic neuron (mDA) specification. mDA cultures at day 65 of differentiation responded to 25 days of the tankyrase inhibitor XAV969 (XAV, 100nM) with reduced
Autor:
Nicole Polain, Wai Sin Kwong, Thomas Ratajczak, Sarah L. Rea, John P. Walsh, Carmel Cluning, Melanie A. Sultana, Jiake Xu, Nathan J. Pavlos
Publikováno v:
PLoS ONE
PLoS ONE, Vol 16, Iss 11, p e0259556 (2021)
PLoS ONE, Vol 16, Iss 11 (2021)
PLoS ONE, Vol 16, Iss 11, p e0259556 (2021)
PLoS ONE, Vol 16, Iss 11 (2021)
The LIM-domain containing protein Ajuba and the scaffold protein SQSTM1/p62 regulate signalling of NF-κB, a transcription factor involved in osteoclast differentiation and survival. The ubiquitin-associated domain of SQSTM1/p62 is frequently mutated
Autor:
Meseret Abebe, Rawleigh Howe, Helina Mollalign, Katrin Bauer, Vincent C. Marconi, Wegene Tamene, Liya Wassie, Amha Kebede, Ulrich Sack
Publikováno v:
PLoS ONE
PLoS ONE, Vol 16, Iss 10, p e0258122 (2021)
PLoS ONE, Vol 16, Iss 10, p e0258122 (2021)
Introduction PDL1 and its interaction with PD1 is implicated in immune dysfunction in TB and HIV. The expression of PDL1 on multiple subsets of monocytes as well as their associations with cytokines and microbial products have not been well studied.
Publikováno v:
PLoS ONE
PLoS ONE, Vol 16, Iss 10, p e0258029 (2021)
PLoS ONE, Vol 16, Iss 10, p e0258029 (2021)
Gluten-specific CD4+ T cells drive the pathogenesis of celiac disease and circulating gluten-specific T cells can be identified by staining with HLA-DQ:gluten tetramers. In this first single-cell RNA-seq study of tetramer-sorted T cells from untreate
Publikováno v:
PLoS ONE
PLoS ONE, Vol 16, Iss 9, p e0256996 (2021)
PLoS ONE, Vol 16, Iss 9, p e0256996 (2021)
Dyslipidemia, atherosclerosis, and cardiovascular events can be prevented, or treated, using statins, alone or in combination with ezetimibe. The aim of the study was to compare the direct pleiotropic effects of two commonly-used statins (atorvastati
Autor:
Louise N. Reynard, Alexander D. Clark, Arthur G. Pratt, Richard Howey, Najib Naamane, Heather J. Cordell
Publikováno v:
PLoS Genetics
PLoS Genetics, Vol 17, Iss 9, p e1009811 (2021)
PLoS Genetics, Vol 17, Iss 9, p e1009811 (2021)
Bayesian networks can be used to identify possible causal relationships between variables based on their conditional dependencies and independencies, which can be particularly useful in complex biological scenarios with many measured variables. Here
Autor:
Christel Rousseaux, Paolo Spagnolo, Silvia Speca, Caroline Dubuquoy, Pierre Desreumaux, Philippe Chavatte
Publikováno v:
PLoS ONE
PLoS ONE, Vol 16, Iss 9, p e0257281 (2021)
PLoS ONE, Vol 16, Iss 9, p e0257281 (2021)
The development of more effective, better tolerated drug treatments for progressive pulmonary fibrosis (of which idiopathic pulmonary fibrosis is the most common and severe form) is a research priority. The peroxisome proliferator-activated receptor
Publikováno v:
PLoS Pathogens
PLoS Pathogens, Vol 17, Iss 9, p e1009936 (2021)
PLoS Pathogens, Vol 17, Iss 9, p e1009936 (2021)
While Entamoeba histolytica (Eh)-induced pro-inflammatory responses are critical in disease pathogenesis, the downstream signaling pathways that subsequently dampens inflammation and the immune response remains unclear. Eh in contact with macrophages