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Publikováno v:
PLoS ONE
PLoS ONE, Vol 16, Iss 4, p e0250109 (2021)
PLoS ONE, Vol 16, Iss 4, p e0250109 (2021)
Idiopathic pulmonary fibrosis (IPF) and lung cancer share common risk factors, epigenetic and genetic alterations, the activation of similar signaling pathways and poor survival. The aim of this study was to examine the gene expression profiles of st
Autor:
Marat S. Pavlyukov, L. I. Patrushev, Mikhail I. Shakhparonov, Alina M. Gamisoniya, Ksenia Anufrieva, Ksenia V. Morozova, T. F. Kovalenko, Lyudmila A. Ozolinya, Mikhail Yu. Bobrov, Yulia E. Dobrokhotova
Publikováno v:
PLoS ONE
PLoS ONE, Vol 16, Iss 1, p e0243093 (2021)
PLoS ONE, Vol 16, Iss 1, p e0243093 (2021)
The processed pseudogene PTENP1 is involved in the regulation of the expression of the PTEN and acts as a tumor suppressor in many types of malignances. In our previous study we showed that PTENP1 methylation is present not only in tumor, but also in
Autor:
Clara Benna, Alessandra Comparato, Salvatore Pucciarelli, Andrea Errico, Isacco Maretto, Marina Bortolami, Fabio Farinati, Umberto Cillo
Publikováno v:
PLoS ONE
PLoS ONE, Vol 15, Iss 12, p e0244356 (2020)
PLoS ONE, Vol 15, Iss 12, p e0244356 (2020)
The physiological role of autophagy in the progression of liver diseases is still debated. To understand the clinical relevance of autophagy in primary e secondary hepatic tumors, we analyzed the expression of mTOR (mammalian target of rapamycin), a
Autor:
Yajie Zhang, Huiling Yang, Qinping Jiang, Xiaoli Yu, Weiren Luo, Ying Zhou, Weiyi Fang, Xin Li, Hao Wang, Yan Zhen, Zhen Liu, Kaitai Yao, Yanfen Ye
Publikováno v:
PLoS ONE
PLoS ONE, Vol 6, Iss 11, p e27887 (2011)
PLoS ONE, Vol 6, Iss 11, p e27887 (2011)
Background Recently we identified nasopharyngeal epithelium specific protein 1 (NESG1) as a potential tumor suppressor in nasopharyngeal carcinoma (NPC). The purpose of this study is to investigate the involvement of NESG1 in tumor progression and pr
Publikováno v:
PLoS ONE
PLoS ONE, Vol 15, Iss 3, p e0230622 (2020)
PLoS ONE, Vol 15, Iss 3, p e0230622 (2020)
Background Circulating tumor DNA (ctDNA) is cell-free DNA that is released into peripheral blood by tumor cells. ctDNA harbors somatic mutations and mutant ctDNA obtained from blood can be used as a biomarker in advanced non-small cell lung cancer (N
Autor:
Radosław Drozd, Tomasz Żabski, Wenancjusz Domagala, Ludmiła Halczy-Kowalik, Arleta Drozd, Ewa Stachowska
Publikováno v:
PLoS ONE
PLoS ONE, Vol 14, Iss 6, p e0218246 (2019)
PLoS ONE, Vol 14, Iss 6, p e0218246 (2019)
Squamous cell carcinoma of the oral cavity mucosa grows under conditions of poor oxygenation and nutrient scarcity. Reprogramming of lipid biosynthesis accompanies tumor growth, but the conditions under which it occurs are not fully understood. The f
Publikováno v:
PLoS ONE
PLoS ONE, Vol 13, Iss 7, p e0200633 (2018)
PLoS ONE, Vol 13, Iss 7, p e0200633 (2018)
PURPOSE:Lung cancer is the deadliest known cancer in the world, with the highest number of mutations in proto-oncogenes and tumor suppressor genes. Therefore, this study was conducted to determine the status of hotspot regions in DDR2 and KRAS genes
Autor:
Jordan Madic, Aurelie Honore, Etienne Rouleau, Magali Droniou, Benjamin Besse, Cécile Jovelet, Romain Girard, Jordi Remon, Ludovic Lacroix, Barbara André
Publikováno v:
PLoS ONE
PLoS ONE, Vol 12, Iss 8, p e0183319 (2017)
PLoS ONE, Vol 12, Iss 8, p e0183319 (2017)
Over the past years, targeted therapies using tyrosine kinase inhibitors (TKI) have led to an increase in progression-free survival and response rate for a subgroup of non-small cell lung cancer (NSCLC) patients harbouring specific gene abnormalities
Autor:
Kazuhiko Koike, Masaya Sato, Yutaka Yatomi, Baasanjav Uranbileg, Kiyoshi Hasegawa, Hitoshi Ikeda, Hiroki Kudo, Kenichiro Enooku, Norihiro Kokudo, Makoto Kurano, Harufumi Maki
Publikováno v:
PLoS ONE
PLoS ONE, Vol 11, Iss 9, p e0161825 (2016)
PLoS ONE, Vol 11, Iss 9, p e0161825 (2016)
Hepatocellular carcinoma (HCC) commonly develops in patients with liver fibrosis; in these patients, the blood levels of lysophosphatidic acid (LPA) and its generating enzyme autotaxin (ATX) increase with the liver fibrosis stage. We aimed to examine
Autor:
Timon Heide, Till Braunschweig, Edgar Dahl, Janina Gasthaus, Ruth Knüchel, Janina Tiedemann, Julian Eschenbruch, Jolein Mijnes, Vera Kloten, Martin Schlensog
Publikováno v:
PLoS ONE
PLOS ONE 11(7), e0159073 (2016). doi:10.1371/journal.pone.0159073
PLoS ONE, Vol 11, Iss 7, p e0159073 (2016)
PLOS ONE 11(7), e0159073 (2016). doi:10.1371/journal.pone.0159073
PLoS ONE, Vol 11, Iss 7, p e0159073 (2016)
PLoS one 11(7), e0159073 (2016). doi:10.1371/journal.pone.0159073
Published by PLoS, Lawrence, Kan.
Published by PLoS, Lawrence, Kan.