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Publikováno v:
PLoS ONE
PLoS ONE, Vol 16, Iss 12, p e0261730 (2021)
PLoS ONE, Vol 16, Iss 12, p e0261730 (2021)
In this study we investigate how β-catenin-dependent WNT signalling impacts midbrain dopaminergic neuron (mDA) specification. mDA cultures at day 65 of differentiation responded to 25 days of the tankyrase inhibitor XAV969 (XAV, 100nM) with reduced
Autor:
Antônio Lacerda Filho, André Lopes Saraiva, Rodrigo Rodrigues Franco, Allisson Benatti Justino, Maria de Fátima Leite, Andressa França, Rodrigo M. Florentino, Foued Salmen Espindola, Matheus de Castro Fonseca
Publikováno v:
PLoS ONE
PLoS ONE, Vol 16, Iss 7, p e0250394 (2021)
PLoS ONE, Vol 16, Iss 7, p e0250394 (2021)
Plant species from Annonaceae are commonly used in traditional medicine to treat various cancer types. This study aimed to investigate the antiproliferative potential of an alkaloid and acetogenin-rich fraction from the fruit peel of Annona crassiflo
Publikováno v:
PLoS ONE
PLoS ONE, Vol 16, Iss 6, p e0252587 (2021)
PLoS ONE, Vol 16, Iss 6, p e0252587 (2021)
Living organisms are continuously under threat from a vast array of DNA-damaging agents, which impact genome DNA. DNA replication machinery stalls at damaged template DNA. The stalled replication fork is restarted via bypass replication by translesio
Autor:
Violetta Ayvazyan, Ani Stepanyan, Guido Hildebrandt, Elina Arakelova, Arsen Arakelyan, Vahan Tonoyan, Gohar Tsakanova, Elisabeth Schültke
Publikováno v:
PLoS ONE
PLoS ONE, Vol 16, Iss 6, p e0253553 (2021)
PLoS ONE, Vol 16, Iss 6, p e0253553 (2021)
For the last years, copper complexes have been intensively implicated in biomedical research as components of cancer treatment. Herewith, we provide highlights of the synthesis, physical measurements, structural characterization of the newly develope
Publikováno v:
PLoS ONE
PLoS ONE, Vol 16, Iss 6, p e0252820 (2021)
PLoS ONE, Vol 16, Iss 6, p e0252820 (2021)
Three scarce terpenes, psiadin, plectranthone and saudinolide, were obtained after chromatographic isolation and purification from the aerial parts of the respective plants. Their identities were established based on their spectral data. Their antica
Publikováno v:
PLoS ONE
PLoS ONE, Vol 16, Iss 5, p e0251172 (2021)
PLoS ONE, Vol 16, Iss 5, p e0251172 (2021)
Within the classical eye-blink conditioning, Purkinje cells within the cerebellum are known to suppress their tonic firing rates for a well defined time period in response to the conditional stimulus after training. The temporal profile of the drop i
Autor:
Janita P Hogan, Bradford E. Peercy
Publikováno v:
PLoS ONE
PLoS ONE, Vol 16, Iss 4, p e0248974 (2021)
PLoS ONE, Vol 16, Iss 4, p e0248974 (2021)
Pancreatic β cells, responsible for secreting insulin into the bloodstream and maintaining glucose homeostasis, are organized in the islets of Langerhans as clusters of electrically coupled cells. Gap junctions, connecting neighboring cells, coordin
Publikováno v:
PLoS ONE
PLoS ONE, Vol 16, Iss 4, p e0249601 (2021)
PLoS ONE, Vol 16, Iss 4, p e0249601 (2021)
Skeletal muscle tissue has a highly complex and heterogeneous structure comprising several physical length scales. In the simplest model of muscle tissue, it can be represented as a one dimensional nonlinear spring in the direction of muscle fibres.
Publikováno v:
Shamu, Tinei; Chimbetete, Cleophas; Egger, Matthias; Mudzviti, Tinashe (2021). Treatment outcomes in HIV infected patients older than 50 years attending an HIV clinic in Harare, Zimbabwe: A cohort study. PLoS ONE, 16(6), e0253000. Public Library of Science 10.1371/journal.pone.0253000
Shamu, T, Chimbetete, C, Egger, M & Mudzviti, T 2021, ' Treatment outcomes in HIV infected patients older than 50 years attending an HIV clinic in Harare, Zimbabwe : A cohort study ', PLoS ONE, vol. 16, no. 6, e0253000 . https://doi.org/10.1371/journal.pone.0253000
PLoS ONE, Vol 16, Iss 6, p e0253000 (2021)
PLoS ONE
Shamu, T, Chimbetete, C, Egger, M & Mudzviti, T 2021, ' Treatment outcomes in HIV infected patients older than 50 years attending an HIV clinic in Harare, Zimbabwe : A cohort study ', PLoS ONE, vol. 16, no. 6, e0253000 . https://doi.org/10.1371/journal.pone.0253000
PLoS ONE, Vol 16, Iss 6, p e0253000 (2021)
PLoS ONE
There is a growing number of older people living with HIV (OPLHIV). While a significant proportion of this population are adults growing into old age with HIV, there are also new infections among OPLHIV. There is a lack of data describing the outcome
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c4b2bcbb24d9cd364f9d7b5446c890b
Publikováno v:
PLoS ONE
PLoS ONE, Vol 15, Iss 12, p e0242773 (2020)
PLoS ONE, Vol 15, Iss 12, p e0242773 (2020)
Autism Spectrum Disorder (ASD) is a heterogeneous disorder that is often accompanied with many co-morbidities. Recent genetic studies have identified various pathways from hundreds of candidate risk genes with varying levels of association to ASD. Ho