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Publikováno v:
PLoS Computational Biology
PLoS Computational Biology, Vol 17, Iss 12, p e1009609 (2021)
PLoS Computational Biology, Vol 17, Iss 12, p e1009609 (2021)
Transcranial direct current stimulation (tDCS) of the cerebellum has rapidly raised interest but the effects of tDCS on cerebellar neurons remain unclear. Assessing the cellular response to tDCS is challenging because of the uneven, highly stratified
Publikováno v:
PLoS ONE
PLoS ONE, Vol 16, Iss 12, p e0261730 (2021)
PLoS ONE, Vol 16, Iss 12, p e0261730 (2021)
In this study we investigate how β-catenin-dependent WNT signalling impacts midbrain dopaminergic neuron (mDA) specification. mDA cultures at day 65 of differentiation responded to 25 days of the tankyrase inhibitor XAV969 (XAV, 100nM) with reduced
Autor:
Kristin V. Carson-Chahhoud, Brian J. Smith, Matthew J. Peters, Malcolm P. Brinn, Faisal Ameer, Kuljit Singh, Robert Fitridge, John Litt, David Edwards, Simon A. Koblar, Jim Jannes, Antony J. Veale, Sharon Goldsworthy, Khin Hnin, Adrian J. Esterman
Publikováno v:
PLoS ONE
PLoS ONE, Vol 15, Iss 4, p e0231095 (2020)
PLoS ONE, Vol 15, Iss 4, p e0231095 (2020)
IntroductionVarenicline tartrate is superior for smoking cessation to other tobacco cessation therapies by 52 weeks, in the outpatient setting. We aimed to evaluate the long-term (104 week) efficacy following a standard course of inpatient-initiated
Autor:
Panagiota Zacharopoulou, David A. Duncan, Susanna Dunachie, Nicholas T.Y. Lim, Robert S. Paton, Craig Thompson, Ian D. Pavord, Derek C. Macallan, W J Hurt, Wentao Chen, Donal T. Skelly, P Goulder, Graham S. Ogg, Jian Luo, Wyncoll Dla., Nicholas M. Provine, Luzheng Xue, Chen Y-L., Philip Hopkins, Ali Amini, E Barnes, Matthew Edmans, Jonathan Ball, Jonathan Youngs, Anna L McNaughton, Paul Klenerman, Hannah Sharpe, Teresa Lambe, Vincent N. Miao, Oliver Sampson, Alex K. Shalek, Tihana Bicanic, Susannah Leaver
Publikováno v:
PLoS Pathogens, Vol 17, Iss 9, p e1009804 (2021)
et al. 2021, ' Identification of immune correlates of fatal outcomes in critically ill COVID-19 patients ', PLoS Pathogens, vol. 17, no. 9, e1009804 . https://doi.org/10.1371/journal.ppat.1009804
PLoS Pathogens
et al. 2021, ' Identification of immune correlates of fatal outcomes in critically ill COVID-19 patients ', PLoS Pathogens, vol. 17, no. 9, e1009804 . https://doi.org/10.1371/journal.ppat.1009804
PLoS Pathogens
Prior studies have demonstrated that immunologic dysfunction underpins severe illness in COVID-19 patients, but have lacked an in-depth analysis of the immunologic drivers of death in the most critically ill patients. We performed immunophenotyping o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b4d1affc75f71fbb1aaddb6a4c83a3de
https://doi.org/10.1371/journal.ppat.1009804
https://doi.org/10.1371/journal.ppat.1009804
Autor:
Chiara Lara Castellazzi, Montserrat Terrazas, Pablo D. Dans, Guillem Portella, Federica Battistini, Isabelle Brun-Heath, Carlos González, Núria Villegas, Modesto Orozco, Mireia Labrador
Publikováno v:
PLoS Computational Biology
PLoS Computational Biology, Vol 17, Iss 11, p e1009547 (2021)
Digital.CSIC. Repositorio Institucional del CSIC
instname
PLoS Computational Biology, Vol 17, Iss 11 (2021)
Dipòsit Digital de la UB
Universidad de Barcelona
PLoS Computational Biology, Vol 17, Iss 11, p e1009547 (2021)
Digital.CSIC. Repositorio Institucional del CSIC
instname
PLoS Computational Biology, Vol 17, Iss 11 (2021)
Dipòsit Digital de la UB
Universidad de Barcelona
Funder: Government of Spain
Funder: Instituci�� Catalana de Recerca i Estudis Avancats
Funder: Programa de Desarrollo de las Ciencias Basicas
Funder: Sistema Nacional de Investigadores, Agencia Nacional de Investigaci��n e Inno
Funder: Instituci�� Catalana de Recerca i Estudis Avancats
Funder: Programa de Desarrollo de las Ciencias Basicas
Funder: Sistema Nacional de Investigadores, Agencia Nacional de Investigaci��n e Inno
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::701e44a65ccc4b6b101da75fa732ff42
http://hdl.handle.net/10261/259111
http://hdl.handle.net/10261/259111
Autor:
Kathryn Crouch, Fiona Achcar, Federica Giordani, Annette MacLeod, Isabel M. Vincent, Pieter C. Steketee, Michael P. Barrett, Liam J. Morrison, Nicholas J. Dickens
Publikováno v:
PLoS Neglected Tropical Diseases
PLoS Neglected Tropical Diseases, Vol 15, Iss 11, p e0009939 (2021)
Steketee, P, Giordani, F, Vincent, I M, Crouch, K, Achcar, F, Dickens, N J, Morrison, L, MacLeod, A & Barrett, M P 2021, ' 'Transcriptional differentiation of Trypanosoma brucei during in vitro acquisition of resistance to acoziborole ', PLoS Neglected Tropical Diseases, vol. 15, no. 11, e0009939 . https://doi.org/10.1371/journal.pntd.0009939
PLoS Neglected Tropical Diseases, Vol 15, Iss 11, p e0009939 (2021)
Steketee, P, Giordani, F, Vincent, I M, Crouch, K, Achcar, F, Dickens, N J, Morrison, L, MacLeod, A & Barrett, M P 2021, ' 'Transcriptional differentiation of Trypanosoma brucei during in vitro acquisition of resistance to acoziborole ', PLoS Neglected Tropical Diseases, vol. 15, no. 11, e0009939 . https://doi.org/10.1371/journal.pntd.0009939
Subspecies of the protozoan parasite Trypanosoma brucei are the causative agents of Human African Trypanosomiasis (HAT), a debilitating neglected tropical disease prevalent across sub-Saharan Africa. HAT case numbers have steadily decreased since the
Autor:
Sayedeh Hussaini, Stefan Luther, Eberhard Bodenschatz, Vladimir S. Zykov, Rupamanjari Majumder
Publikováno v:
PLoS Computational Biology
PLoS Computational Biology, Vol 17, Iss 10, p e1009476 (2021)
PLoS Computational Biology, Vol 17, Iss 10, p e1009476 (2021)
Interruptions in nonlinear wave propagation, commonly referred to as wave breaks, are typical of many complex excitable systems. In the heart they lead to lethal rhythm disorders, the so-called arrhythmias, which are one of the main causes of sudden
Autor:
Amrit P. Singh, Frank Schmitz, Adam Z. Rosenthal, Madhav V. Dhodapkar, Antje Hoering, Daisy Alapat, Yan Ren, Maurizio Zangari, Kelsie Smith, Samuel A. Danziger, Jake Gockley, Andrew Dervan, Alexander V. Ratushny, Mark McConnell, Robert M. Hershberg, Suzana Couto, Brian A Walker, Faith E. Davies, Alison Fitch, Wilbert B. Copeland, Gareth J. Morgan, Bart Barlogie, Phil Farmer, David J. Reiss, Brian Fox, Mary H. Young, Frits van Rhee, Cody Ashby, Katie Newhall, Nathan Petty, Michael A Bauer, Robert Z. Orlowski, Matthew Trotter
Publikováno v:
PLoS Medicine
PLoS Medicine, Vol 17, Iss 11, p e1003323 (2020)
PLoS Medicine, Vol 17, Iss 11, p e1003323 (2020)
Background The tumor microenvironment (TME) is increasingly appreciated as an important determinant of cancer outcome, including in multiple myeloma (MM). However, most myeloma microenvironment studies have been based on bone marrow (BM) aspirates, w
Autor:
Connor G. G. Bamford, Milagros Rodriguez Collados, Alfredo Castello, Srikeerthana Kuchi, David Robertson, Nardus Mollentze, Sam J. Wilson, Joseph Busby, Arthur Wickenhagen, Douglas G. Stewart, Richard J. Orton, Siddharth Bakshi, Quan Gu, Elena Sugrue, Matthew L. Turnbull, Daniel G. Streicker, Massimo Palmarini, Suzannah J. Rihn, Andrew Shaw, Ana Filipe da Silva, Paul C. D. Johnson, Katherine Smollett
Publikováno v:
PLoS Biology
PLoS Biology, Vol 19, Iss 9, p e3001352 (2021)
PLoS Biology, Vol 19, Iss 9, p e3001352 (2021)
Antiviral defenses can sense viral RNAs and mediate their destruction. This presents a challenge for host cells since they must destroy viral RNAs while sparing the host mRNAs that encode antiviral effectors. Here, we show that highly upregulated int
Publikováno v:
PLoS Pathogens
PLoS Pathogens, Vol 17, Iss 8, p e1009902 (2021)
PLoS Pathogens, Vol 17, Iss 8, p e1009902 (2021)
Funder: Isaac Newton Trust; funder-id: http://dx.doi.org/10.13039/501100004815
The p21-activated kinase (PAK) family regulate a multitude of cellular processes, including actin cytoskeleton remodelling. Numerous bacterial pathogens usurp host si
The p21-activated kinase (PAK) family regulate a multitude of cellular processes, including actin cytoskeleton remodelling. Numerous bacterial pathogens usurp host si
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06910e255d295fd7a61dbe1783ca72a1
https://www.repository.cam.ac.uk/handle/1810/327872
https://www.repository.cam.ac.uk/handle/1810/327872