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Autor:
Ab Rauf Shah, Bhanwar Lal Puniya, Matteo Barberis, Alyssa La Fleur, Tomáš Helikar, Kenneth Y. Wertheim
Publikováno v:
PLoS Computational Biology, Vol 17, Iss 8, p e1009209 (2021)
PLoS Computational Biology, 17(8):e1009209. Public Library of Science
PLoS Computational Biology
PLoS Computational Biology, 17(8):e1009209. Public Library of Science
PLoS Computational Biology
Immune responses rely on a complex adaptive system in which the body and infections interact at multiple scales and in different compartments. We developed a modular model of CD4+ T cells, which uses four modeling approaches to integrate processes at
Publikováno v:
PLoS ONE
PLoS ONE, Vol 16, Iss 8 (2021)
PLoS ONE, Vol 16, Iss 8, p e0255639 (2021)
PLoS ONE, Vol 16, Iss 8 (2021)
PLoS ONE, Vol 16, Iss 8, p e0255639 (2021)
This study was aimed at exploring whether latent tuberculosis infection (LTBI) contributes to the pathogenesis of immune-mediated inflammatory diseases in a TB endemic setting. We screened 198 rheumatoid arthritis (RA) patients with tuberculin skin t
Autor:
Joseph Leedale, Fiona Roberts, Craig Murdoch, Simon Walker-Samuel, Rebecca J. Shipley, Hannah West, Paul W. Sweeney, Helen E. Colley, Steven D. Webb
Publikováno v:
PLoS ONE
PLoS One
PLoS ONE, Vol 16, Iss 7, p e0254208 (2021)
PLOS ONE
PLoS One
PLoS ONE, Vol 16, Iss 7, p e0254208 (2021)
PLOS ONE
Nanoparticles have the potential to increase the efficacy of anticancer drugs whilst reducing off-target side effects. However, there remain uncertainties regarding the cellular uptake kinetics of nanoparticles which could have implications for nanop
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e995e8260976047379fc9cd9e068ae26
https://www.repository.cam.ac.uk/handle/1810/325830
https://www.repository.cam.ac.uk/handle/1810/325830
Autor:
Yaohua Fan, Zhihao Ding, Xulin Chen, Pin Wan, Geng Li, Qiwei Zhang, Keli Chen, Wenbiao Wang, Pan Pan, Zhenyang Yu, Zhen Luo, Zizhao Lao, Muhammad Adnan Shereen, Luping Lin, Miaomiao Shen, Weiwei Ge, Jianguo Wu
Publikováno v:
PLoS Pathogens
PLoS Pathogens, Vol 17, Iss 7, p e1008603 (2021)
PLoS Pathogens, Vol 17, Iss 7, p e1008603 (2021)
Dengue virus (DENV) is a mosquito-borne pathogen that causes a spectrum of diseases including life-threatening dengue hemorrhagic fever (DHF) and dengue shock syndrome (DSS). Vascular leakage is a common clinical crisis in DHF/DSS patients and highly
Autor:
Tilakavati Karupaiah, Soelaiman Ima-Nirwana, Shing Cheng Tan, Hui-Ci Tiong, Kok-Yong Chin, Abdul Halim Abdul Gafor, Sok Kuan Wong, Ban-Hock Khor
Publikováno v:
PLoS ONE
PLoS ONE, Vol 16, Iss 7, p e0255205 (2021)
PLoS ONE, Vol 16, Iss 7, p e0255205 (2021)
Studies investigating the effects of tocotrienols on inflammation and oxidative stress have yielded inconsistent results. This systematic review and meta-analysis aimed to evaluate the effects of tocotrienols supplementation on inflammatory and oxida
Autor:
Fatima Noor, Muhammad Hamzah Saleem, Jen-Tsung Chen, Muhammad Rizwan Javed, Wafa Abdullah Al-Megrin, Sidra Aslam
Publikováno v:
PLoS ONE
PLoS ONE, Vol 16, Iss 7, p e0254678 (2021)
PLoS ONE, Vol 16, Iss 7, p e0254678 (2021)
Extramammary Paget’s disease (EMPD) is an intra-epidermal adenocarcinoma. Till now, the mechanisms underlying the pathogenesis of scrotal EMPD is poorly known. This present study aims to explore the knowledge of molecular mechanism of scrotal EMPD
Publikováno v:
PLoS ONE
PLoS ONE, Vol 16, Iss 7, p e0254783 (2021)
PLoS ONE, Vol 16, Iss 7, p e0254783 (2021)
An array of isoforms of the nuclear estrogen receptor alpha (ER-α) protein contribute to heterogeneous response in breast cancer (BCa); yet, a single-cell analysis tool that distinguishes the full-length ER-α66 protein from the activation function-
Autor:
Salvatore La Rosa, Helen Morrison, Jie Huang, Rajarshi Guha, Li Jiang, Yongzheng He, Gary L. Johnson, Steven P. Angus, Eric T. Hawley, Vijaya Ramesh, Justin Guinney, Sarah S. Burns, Jin Yuan, Roberta L. Beauchamp, Lars Björn Riecken, Cristina Fernandez-Valle, Marc Ferrer, Charles W. Yates, Serkan Erdin, Abbi Smith, Waylan K. Bessler, D. Bradley Welling, D. Wade Clapp, Shelley Dixon, Scott R. Plotkin, Ming Poi, Thomas S. K. Gilbert, Anat Stemmer-Rachamimov, Alejandra M. Petrilli, Craig J. Thomas, Xiaohong Li, Qingbo Lu, David R. Jones, James F. Gusella, Long-Sheng Chang, Andrea R. Masters, Xiaohu Zhang, Janet L. Oblinger, Jaishri O. Blakeley, Stephen J. Haggarty
Publikováno v:
PLoS ONE
PLoS ONE, Vol 16, Iss 7, p e0252048 (2021)
PLoS ONE, Vol 16, Iss 7, p e0252048 (2021)
Neurofibromatosis Type 2 (NF2) is an autosomal dominant genetic syndrome caused by mutations in the NF2 tumor suppressor gene resulting in multiple schwannomas and meningiomas. There are no FDA approved therapies for these tumors and their relentless
Autor:
Pornchai Rojsitthisak, Koichi Matsuda, Watchara Sakares, Chizu Tanikawa, Varalee Yodsurang, Muttarin Lothong
Publikováno v:
PLoS ONE
PLoS ONE, Vol 16, Iss 7, p e0255179 (2021)
PLoS ONE, Vol 16, Iss 7, p e0255179 (2021)
Collagen XVII (COL17), a cell-matrix adhesion protein, has been found to be suppressed in breast cancer. Our previous data demonstrated a preventive role of COL17 in breast cancer invasiveness. The present study used the stable COL17-overexpressing M
Autor:
Frédéric de Blay, Virginie Doyen, Olivier Michel, Hiep Tran Thi Mong, Thanh Le Chi, Phuong Thi Ngoe Huynh, Francis Corazza, Hoa Nhu Thi, Carine Truyens
Publikováno v:
PLoS ONE
PLoS ONE, Vol 16, Iss 7, p e0253887 (2021)
PLoS ONE, Vol 16, Iss 7, p e0253887 (2021)
Background IgE characterizes the humoral response of allergic sensitization but less is known about what modulates its function and why some patients present clinical symptoms for a given IgE level and others do not. An IgE response also occurs durin