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of 405
pro vyhledávání: ''
Autor:
Shuqin Li, Meiting Wang, Yingdong Song, Wei Zhang, Fanghong Shao, Xiaolin Liang, Ge Shan, Xiangting Wang, Junxia Lu, Bowen Zhang, Meng Gong, Wei Wang, Yan Jin, Zhi Zhang
Publikováno v:
PLoS Biology
PLoS Biology, Vol 19, Iss 6, p e3001297 (2021)
PLoS Biology, Vol 19, Iss 6, p e3001297 (2021)
Recent studies have shown that long noncoding RNAs (lncRNAs) are critical regulators in the central nervous system (CNS). However, their roles in the cerebellum are currently unclear. In this work, we identified the isoform 204 of lncRNA Gm2694 (desi
Publikováno v:
PLoS Neglected Tropical Diseases
PLoS Neglected Tropical Diseases, Vol 15, Iss 6, p e0009472 (2021)
PLoS Neglected Tropical Diseases, Vol 15, Iss 6, p e0009472 (2021)
Background Hepatic stellate cells (HSCs) are one of the main cell types involved in liver fibrosis induced by many factors, including schistosomes. Previous studies in our lab have shown that recombinant P40 protein from Schistosoma japonicum (rSjP40
Autor:
Katherine M. Morrison, John Penders, Jennifer C. Stearns, Monique Mommers, Liene Bervoets, Niels van Best, Eileen K. Hutton, Jenifer Li, Sara Dizzell
Publikováno v:
PLoS ONE
PLOS ONE, 16(4):e0248924. Public Library of Science
PLOS ONE 16(4), 0248924 (2021). doi:10.1371/journal.pone.0248924
PLoS ONE, Vol 16, Iss 4, p e0248924 (2021)
PLOS ONE, 16(4):e0248924. Public Library of Science
PLOS ONE 16(4), 0248924 (2021). doi:10.1371/journal.pone.0248924
PLoS ONE, Vol 16, Iss 4, p e0248924 (2021)
PLOS ONE 16(4), 0248924 (2021). doi:10.1371/journal.pone.0248924
Published by PLOS, San Francisco, California, US
Published by PLOS, San Francisco, California, US
Publikováno v:
PLoS Biology
PLoS Biology, Vol 19, Iss 3, p e3000886 (2021)
PLoS Biology, Vol 19, Iss 3, p e3000886 (2021)
Faithful replication of the entire genome requires replication forks to copy large contiguous tracts of DNA, and sites of persistent replication fork stalling present a major threat to genome stability. Understanding the distribution of sites at whic
Autor:
Konstantinos Giannakis, David M. Edwards, Robert C. Glastad, Iain G. Johnston, Ellen C. Røyrvik, Joanna M. Chustecki, Arunas L. Radzvilavicius
Publikováno v:
e3001153
PLoS Biology
PLoS Biology, Vol 19, Iss 4, p e3001153 (2021)
PLoS Biology
PLoS Biology, Vol 19, Iss 4, p e3001153 (2021)
Mitochondrial DNA (mtDNA) and plastid DNA (ptDNA) encode vital bioenergetic apparatus, and mutations in these organelle DNA (oDNA) molecules can be devastating. In the germline of several animals, a genetic “bottleneck” increases cell-to-cell var
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b2f63bf3b79b80e102c3273eddfdcb67
https://hdl.handle.net/11250/2983335
https://hdl.handle.net/11250/2983335
Autor:
Ronaldo Honorato Barros Santos, Fernando Bacal, Frederico Moraes Ferreira, Jorge Kalil, Amanda Farage Frade, Pauline Brochet, Vanessa Escolano Maso, João Paulo Silva Nunes, Laurie Laugier, Helder I. Nakaya, Ludmila Rodrigues Pinto Ferreira, Priscila Camillo Teixeira, Edecio Cunha-Neto, Sandrine Cabantous, Christophe Chevillard, Rafael Almeida Ribeiro, Edimar Alcides Bocchi, Darlan da Silva Cândido
Publikováno v:
PLoS Neglected Tropical Diseases
Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
PLoS Neglected Tropical Diseases, Public Library of Science, 2020, 14, ⟨10.1371/journal.pntd.0008889⟩
PLoS Neglected Tropical Diseases, Vol 14, Iss 12, p e0008889 (2020)
PLoS Neglected Tropical Diseases, 2020, 14, ⟨10.1371/journal.pntd.0008889⟩
Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
PLoS Neglected Tropical Diseases, Public Library of Science, 2020, 14, ⟨10.1371/journal.pntd.0008889⟩
PLoS Neglected Tropical Diseases, Vol 14, Iss 12, p e0008889 (2020)
PLoS Neglected Tropical Diseases, 2020, 14, ⟨10.1371/journal.pntd.0008889⟩
Chronic Chagas disease cardiomyopathy (CCC), an especially aggressive inflammatory dilated cardiomyopathy caused by lifelong infection with the protozoan Trypanosoma cruzi, is a major cause of cardiomyopathy in Latin America. Although chronic myocard
Autor:
Pasan Fernando, Hadil Sayed, Bruce C. McKay, Erin J. Vanzyl, Kayleigh R C Rick, Alex B. Blackmore
Publikováno v:
PLoS ONE
PLoS ONE, Vol 15, Iss 12, p e0224953 (2020)
PLoS ONE, Vol 15, Iss 12, p e0224953 (2020)
The spliceosome assembles on pre-mRNA in a stepwise manner through five successive pre-spliceosome complexes. The spliceosome functions to remove introns from pre-mRNAs to generate mature mRNAs that encode functional proteins. Many small molecule inh
Publikováno v:
PLoS Computational Biology
PLoS Computational Biology, Vol 16, Iss 12, p e1008488 (2020)
PLoS Computational Biology, Vol 16, Iss 12, p e1008488 (2020)
NF-Y is a trimeric Transcription Factor -TF- which binds with high selectivity to the conserved CCAAT element. Individual ChIP-seq analysis as well as ENCODE have progressively identified locations shared by other TFs. Here, we have analyzed data int
Autor:
Roberto Texeira de Lima, Raquel Patrícia Ataíde Lima, Rafaella Cristhine Pordeus Luna, Jéssica Vicky Bernardo de Oliveira, Sônia Cristina Pereira de Oliveira Ramalho Diniz, Darlene Camati Persuhn, Maria da Conceição Rodrigues Gonçalves, Alcides da Silva Diniz, Naila Francis Paulo de Oliveira, Aléssio Tony Cavalcanti de Almeida, Maria José de Carvalho Costa, Alexandre Sérgio Silva, Ana Hermínia Andrade e Silva, Flávia Emília Leite de Lima Ferreira
Publikováno v:
PLoS ONE
PLoS ONE, Vol 15, Iss 12, p e0239989 (2020)
PLoS ONE, Vol 15, Iss 12, p e0239989 (2020)
Low-density lipoprotein (LDL-C) concentrations are a standard of care in the prevention of cardiovascular disease and are influenced by different factors. This study compared the LDL-C concentrations estimated by two different equations and determine
Autor:
Zhuoya Li, Jing Wang, Bingjiao Yin, Chenxi Li, Ling Zhou, Xiang-Ping Yang, Kun Miao, Hongping Ba, Haiyan Gu, Dao Wen Wang
Publikováno v:
PLoS Biology
PLoS Biology, Vol 18, Iss 12, p e3000967 (2020)
PLoS Biology, Vol 18, Iss 12, p e3000967 (2020)
Tumor necrosis factor-alpha (TNF-α) plays an important pathogenic role in cardiac hypertrophy and heart failure (HF); however, anti-TNF is paradoxically negative in clinical trials and even worsens HF, indicating a possible protective role of TNF-α