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Autor:
Ab Rauf Shah, Bhanwar Lal Puniya, Matteo Barberis, Alyssa La Fleur, Tomáš Helikar, Kenneth Y. Wertheim
Publikováno v:
PLoS Computational Biology, Vol 17, Iss 8, p e1009209 (2021)
PLoS Computational Biology, 17(8):e1009209. Public Library of Science
PLoS Computational Biology
PLoS Computational Biology, 17(8):e1009209. Public Library of Science
PLoS Computational Biology
Immune responses rely on a complex adaptive system in which the body and infections interact at multiple scales and in different compartments. We developed a modular model of CD4+ T cells, which uses four modeling approaches to integrate processes at
Publikováno v:
PLoS ONE
PLoS ONE, Vol 16, Iss 8 (2021)
PLoS ONE, Vol 16, Iss 8, p e0255639 (2021)
PLoS ONE, Vol 16, Iss 8 (2021)
PLoS ONE, Vol 16, Iss 8, p e0255639 (2021)
This study was aimed at exploring whether latent tuberculosis infection (LTBI) contributes to the pathogenesis of immune-mediated inflammatory diseases in a TB endemic setting. We screened 198 rheumatoid arthritis (RA) patients with tuberculin skin t
Autor:
Yaohua Fan, Zhihao Ding, Xulin Chen, Pin Wan, Geng Li, Qiwei Zhang, Keli Chen, Wenbiao Wang, Pan Pan, Zhenyang Yu, Zhen Luo, Zizhao Lao, Muhammad Adnan Shereen, Luping Lin, Miaomiao Shen, Weiwei Ge, Jianguo Wu
Publikováno v:
PLoS Pathogens
PLoS Pathogens, Vol 17, Iss 7, p e1008603 (2021)
PLoS Pathogens, Vol 17, Iss 7, p e1008603 (2021)
Dengue virus (DENV) is a mosquito-borne pathogen that causes a spectrum of diseases including life-threatening dengue hemorrhagic fever (DHF) and dengue shock syndrome (DSS). Vascular leakage is a common clinical crisis in DHF/DSS patients and highly
Autor:
Hal E. Broxmeyer, Elizabeth A. Williamson, Sarah C. Glover, Austin Kirby, Yilianys Pride, Maegan L. Capitano, Aruna S. Jaiswal, Gayathri Srinivasan, Daniel D Mais, Robert Hromas, Fatemah G. Amlashi
Publikováno v:
PLoS ONE
PLoS ONE, Vol 16, Iss 7, p e0252805 (2021)
PLoS ONE, Vol 16, Iss 7, p e0252805 (2021)
Chemokines are small proteins that promote leukocyte migration during development, infection, and inflammation. We and others isolated the unique chemokine CCL21, a potent chemo-attractant for naïve T-cells, naïve B-cells, and immature dendritic ce
Autor:
Christine Johnston, Meei-Li Huang, Fred Okuku, Joshua T. Schiffer, Corey Casper, Anna Wald, Lawrence Corey, Jackson Orem, Habibur Rahman, Soren Gantt, Daniel Coombs, Catherine M. Byrne
Publikováno v:
PLoS Computational Biology
PLoS Computational Biology, Vol 17, Iss 6, p e1009072 (2021)
PLoS Computational Biology, Vol 17, Iss 6, p e1009072 (2021)
Epstein-Barr virus (EBV) is transmitted by saliva and is a major cause of cancer, particularly in people living with HIV/AIDS. Here, we describe the frequency and quantity of EBV detection in the saliva of Ugandan adults with and without HIV-1 infect
Autor:
Ana Carreras-González, Juan Anguita, Sebastiaan M. Van Liempd, Juan M. Falcón-Pérez, Teresa Martín-Mateos, Diana Cabrera, Iraide Escobes, Edurne Berra, Felix Elortza, Estíbaliz Atondo, Mikel Azkargorta, Leticia Abecia, Héctor Rodríguez, Alberto Pascual, Miguel Angel Pascual-Itoiz, Itziar Martín-Ruiz, Diego Barriales, José Luis Lavín, Aize Pellon, María L. Martínez-Chantar, Ana M. Aransay, Ainhoa Palacios, Ibon Iloro, Marta Montesinos-Robledo, Ana R. Cortazar, Juana M. Flores, Ainize Peña-Cearra, Laura Bárcena, Monika Gonzalez-Lopez
Publikováno v:
PLoS Biology, Vol 19, Iss 1, p e3001062 (2021)
PLoS Biology
Digital.CSIC. Repositorio Institucional del CSIC
instname
Digital.CSIC: Repositorio Institucional del CSIC
Consejo Superior de Investigaciones Científicas (CSIC)
PLoS Biology
Digital.CSIC. Repositorio Institucional del CSIC
instname
Digital.CSIC: Repositorio Institucional del CSIC
Consejo Superior de Investigaciones Científicas (CSIC)
Lyme carditis is an extracutaneous manifestation of Lyme disease characterized by episodes of atrioventricular block of varying degrees and additional, less reported cardiomyopathies. The molecular changes associated with the response to Borrelia bur
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c00e342efcef62c4b9ac7e518d89439
http://hdl.handle.net/10261/239544
http://hdl.handle.net/10261/239544
Autor:
Bryan C. Nikolai, Andrew P. Rice, Maureen G. Mancini, Fabio Stossi, P.-W. P. Hu, Julien Dubrulle, H. Liu
Publikováno v:
PLoS ONE
PLoS ONE, Vol 16, Iss 4, p e0244771 (2021)
PLoS ONE, Vol 16, Iss 4, p e0244771 (2021)
Although current antiretroviral therapies (ART) are successful in controlling HIV-1 infection, a stable viral reservoir reactivates when ART is discontinued. Consequently, there is a major research effort to develop approaches to disrupt the latent v
Autor:
Euzenir Nunes Sarno, José Augusto da Costa Nery, Flávio Alves Lara, Mayara Abud Mendes, Pedro Henrique Lopes da Silva, Júlia Monteiro Pereira Leal, Mariana A. Hacker, Milton Ozório Moraes, Roberto Alves Lourenço, Danuza Esquenazi, Katherine Kelda Gomes de Castro, Thyago Leal Calvo
Publikováno v:
PLoS Neglected Tropical Diseases
PLoS Neglected Tropical Diseases, Vol 15, Iss 3, p e0009214 (2021)
PLoS Neglected Tropical Diseases, Vol 15, Iss 3, p e0009214 (2021)
Background Leprosy continues to be a public health problem in Brazil. Furthermore, detection rates in elderly people have increased, particularly those of multibacillary (L-Lep) patients, who are responsible for transmitting M. leprae. Part of the de
Autor:
Diva Denelle Spadacci-Morena, Anuska Marcelino Alvares Saraiva, Fabiana Toshie de Camargo Konno, Elizabeth Cristina Perez, Luciane Costa Dalboni, Jéssica Feliciana Codeceira, Maria Anete Lallo
Publikováno v:
PLoS ONE
PLoS ONE, Vol 16, Iss 3, p e0247658 (2021)
PLoS ONE, Vol 16, Iss 3, p e0247658 (2021)
Microsporidia are recognized as opportunistic pathogens in individuals with immunodeficiencies, especially related to T cells. Although the activity of CD8+ T lymphocytes is essential to eliminate these pathogens, earlier studies have shown significa
Autor:
Stephen DeWall, Sara Brett, Keguan Chen, Andrew Gehman, George R Gunn, Ann M. Schwartz, Karen Liao
Publikováno v:
PLoS ONE
PLoS ONE, Vol 16, Iss 3, p e0249049 (2021)
PLoS ONE, Vol 16, Iss 3, p e0249049 (2021)
Interleukin-7 (IL-7) signaling modulates T cell activity and is implicated in numerous autoimmune diseases. An anti-IL-7 receptor monoclonal antibody (GSK2618960) biotherapeutic was evaluated in healthy subjects for safety, pharmacokinetics (PK), pha