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of 424
pro vyhledávání: ''
Autor:
Connor G. G. Bamford, Milagros Rodriguez Collados, Alfredo Castello, Srikeerthana Kuchi, David Robertson, Nardus Mollentze, Sam J. Wilson, Joseph Busby, Arthur Wickenhagen, Douglas G. Stewart, Richard J. Orton, Siddharth Bakshi, Quan Gu, Elena Sugrue, Matthew L. Turnbull, Daniel G. Streicker, Massimo Palmarini, Suzannah J. Rihn, Andrew Shaw, Ana Filipe da Silva, Paul C. D. Johnson, Katherine Smollett
Publikováno v:
PLoS Biology
PLoS Biology, Vol 19, Iss 9, p e3001352 (2021)
PLoS Biology, Vol 19, Iss 9, p e3001352 (2021)
Antiviral defenses can sense viral RNAs and mediate their destruction. This presents a challenge for host cells since they must destroy viral RNAs while sparing the host mRNAs that encode antiviral effectors. Here, we show that highly upregulated int
Autor:
Jaime Altcheh, Luis Castro, Juan C Dib, Ulrike Grossmann, Erya Huang, Guillermo Moscatelli, Jimy José Pinto Rocha, Teresa Estela Ramírez, CHICO Study Group
Publikováno v:
CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET
PLoS Neglected Tropical Diseases, Vol 15, Iss 1, p e0008912 (2021)
PLoS Neglected Tropical Diseases
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET
PLoS Neglected Tropical Diseases, Vol 15, Iss 1, p e0008912 (2021)
PLoS Neglected Tropical Diseases
Nifurtimox is a recommended treatment for Chagas disease, but data from treated children are limited. We investigated the efficacy, safety and tolerability of nifurtimox administered as divisible, dispersible 30 mg and 120 mg tablets in children with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::21712d252180e11362346c2556b2f933
https://journals.plos.org/plosntds/article?id=10.1371/journal.pntd.0008912
https://journals.plos.org/plosntds/article?id=10.1371/journal.pntd.0008912
Autor:
Fatima Aziz, Sean R. Moore, Jennie Z. Ma, Romana Idress, Sheraz Ahmed, Syed Asad Ali, Najeeha Talat Iqbal, Sana Syed, Junaid Iqbal, Furqan Kabir, Kumail Ahmed, Zubair Ahmed, Adil Kalam, Aneeta Hotwani, Zehra Jamil, Kamran Sadiq, Indika Mallawaarachchi, Fayaz Umrani
Publikováno v:
PLoS Neglected Tropical Diseases
PLoS Neglected Tropical Diseases, Vol 15, Iss 7, p e0009584 (2021)
PLoS Neglected Tropical Diseases, Vol 15, Iss 7, p e0009584 (2021)
Environmental enteric dysfunction (EED) is a subclinical condition of intestinal inflammation, barrier dysfunction and malabsorption associated with growth faltering in children living in poverty. This study explores association of altered duodenal p
Autor:
Gough G. Au, Angela R. Harrison, Glenn A. Marsh, Gregory W. Moseley, Stephen M. Rawlinson, Cassandra T. David, Megan Dearnley, Diane Green, Shawn Todd
Publikováno v:
PLoS Pathogens
PLoS Pathogens, Vol 17, Iss 6, p e1009636 (2021)
PLoS Pathogens, Vol 17, Iss 6, p e1009636 (2021)
Many viruses target signal transducers and activators of transcription (STAT) 1 and 2 to antagonise antiviral interferon signalling, but targeting of signalling by other STATs/cytokines, including STAT3/interleukin 6 that regulate processes important
Autor:
Mohammad Karamouzian, Jane A. Buxton, Brittany S. Graham, Roy Purssell, Kristi Papamihali, Dylan Collins
Publikováno v:
PLoS ONE
PLoS ONE, Vol 16, Iss 5, p e0252090 (2021)
PLoS ONE, Vol 16, Iss 5, p e0252090 (2021)
Introduction Increased use of crystal methamphetamine (“crystal meth”) has been observed across North America and international jurisdictions, including a notable increase in the presence of methamphetamines in illicit drug toxicity deaths in Bri
Autor:
Jason M. Cota, Nathan K Jansen, John D. Fields, Ryan C. Maves, Rhonda E Colombo, Brian K. Agan, Anuradha Ganesan, Taylor M. Benavides, Jason F. Okulicz, Jason M Blaylock
Publikováno v:
PLoS ONE
PLoS ONE, Vol 16, Iss 5, p e0250607 (2021)
PLoS ONE, Vol 16, Iss 5, p e0250607 (2021)
Objectives We sought to determine the prevalence of phosphodiesterase type 5 inhibitor (PDE-5) mediated drug-drug interactions (DDIs) in males with HIV infection receiving antiretroviral therapy (ART) and identify factors associated with PDE-5-mediat
Autor:
Allison Brashear, Stefan Wietek, Stuart Isaacson, William G. Ondo, Mark F. Lew, Pascal Maisonobe, Bruce K. Rubin, Robert A. Hauser, Khashayar Dashtipour, Atul T. Patel
Publikováno v:
PLoS ONE
PLoS ONE, Vol 16, Iss 2, p e0245827 (2021)
PLoS ONE, Vol 16, Iss 4, p e0250475 (2021)
PLoS ONE, Vol 16, Iss 2, p e0245827 (2021)
PLoS ONE, Vol 16, Iss 4, p e0250475 (2021)
Cervical dystonia (CD) is primarily treated with botulinum toxin, at intervals of ≥ 12 weeks. We present efficacy, patient-reported outcomes (PROs), and safety in adults with CD at the last available visit after a single set of abobotulinumtoxinA (
Publikováno v:
PLoS ONE
PLoS ONE, Vol 16, Iss 4, p e0247714 (2021)
PLoS ONE, Vol 16, Iss 4, p e0247714 (2021)
Optimal vancomycin exposure is important to minimize treatment failure of methicillin-resistant Staphylococcus aureus (MRSA) bacteremia. We aimed to analyze the impact of initial vancomycin pharmacokinetic/pharmacodynamic (PK/PD) parameters, includin
Autor:
Martin Onyango, Julius Kiwanuka, Yunia Mayanja, Jonathan Kitonsa, Abu-Baker Ggayi, Yofesi Nikweri, Freddie Kibengo, Rebecca N Nsubuga, Zacchaeus Anywaine, Jeremy N. Day, Pontiano Kaleebu
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 14, Iss 11, p e0008823 (2020)
PLoS Neglected Tropical Diseases
PLoS Neglected Tropical Diseases
Globally, early initiation of antiretroviral therapy for HIV led to a reduction in the estimated mortality from cryptococcal meningitis (CCM) from 624,700 in 2009 to 181,100 in 2014. However, CCM remains one of the leading causes of mortality among H
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1acc9c9e850dbda5dfd93f7c27168fe6
https://doi.org/10.1371/journal.pntd.0008823
https://doi.org/10.1371/journal.pntd.0008823
Autor:
Yemisi Dorcas Obafemi, Akinniyi Paul Akinduti, Joshua Adekunle Osiyemi, Adewale Gideon Adeyemi, Oluwaseun Ejilude, Temitope Temitayo Banjo, Maged El-Ashker, Patrick Omoregie Isibor
Publikováno v:
PLoS ONE
PLoS ONE, Vol 16, Iss 2, p e0247013 (2021)
PLoS ONE, Vol 16, Iss 2, p e0247013 (2021)
Spread of genetically diverse Staphylococcus aureus characterized with multi-antibiotic resistance and regulated by high level agr functionalities in several communities in southwest Nigeria was investigated and evaluated for infection control. Staph