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Publikováno v:
PLoS ONE
PLoS ONE, Vol 13, Iss 8, p e0199936 (2018)
PLoS ONE, Vol 13, Iss 8, p e0199936 (2018)
Ions released from metal implants have been associated with adverse tissue reactions and are therefore a major concern. Studies with macrophages have shown that cobalt, chromium, and nickel ions can activate the NLRP3 inflammasome, a multiprotein com
Autor:
Martin Connock, Aileen Clarke, Pierre-Jean Souquet, Xavier Armoiry, Pamela Royle, G. J. Melendez-Torres, Alexander Tsertsvadze
Publikováno v:
PLoS ONE, Vol 13, Iss 7, p e0199575 (2018)
PLoS ONE
PLoS ONE
Purpose\ud \ud This systematic review with network meta-analysis compared the efficacy and safety of currently licensed second-line treatments in patients with late stage non-small cell lung cancer (NSCLC).\ud \ud Methods\ud \ud Randomised controlled
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e8a665c9269f22e57719b901dc2f1d7
http://wrap.warwick.ac.uk/106463/1/WRAP-comparative-efficacy-safety-licensed-treatments-Armoiry-2018.pdf
http://wrap.warwick.ac.uk/106463/1/WRAP-comparative-efficacy-safety-licensed-treatments-Armoiry-2018.pdf
Autor:
Kensuke Kosugi, Takashi Suto, Toshiyuki Suzuki, Yasuhiko Tabata, Shigeru Saito, Masaru Tobe, Satoshi Yokoo
Publikováno v:
PLoS ONE
PLoS ONE, Vol 13, Iss 7, p e0200059 (2018)
PLoS ONE, Vol 13, Iss 7, p e0200059 (2018)
Background: We have synthesized a sustained-release lidocaine sheet (SRLS) using biodegradable polymers and previously demonstrated its safety and long-term analgesic effect in the normal mucous membrane of healthy human volunteers.
Objectives:
Objectives:
Autor:
Manuel Zeitelhofer, Lars Muhl, Ulf Eriksson, Hong Li, Milena Z. Adzemovic, Ingrid Nilsson, Andrew M. Scott
Publikováno v:
PLoS ONE
PLoS ONE, Vol 13, Iss 7, p e0200649 (2018)
PLoS ONE, Vol 13, Iss 7, p e0200649 (2018)
Platelet-derived growth factor CC (PDGF-CC) is important during foetal development but also in pathogenesis of neurologic diseases, cancer and fibrosis. We have previously demonstrated that blocking the PDGF-CC/PDGF receptor alpha (PDGFRα) axis resu
Publikováno v:
PLoS ONE
PLoS ONE, Vol 13, Iss 7, p e0200442 (2018)
PLoS ONE, Vol 13, Iss 7, p e0200442 (2018)
Background Escherichia coli sequence type 131 (ST131), with its multidrug-resistance-associated H30R1 and H30Rx clonal subsets, causes most antimicrobial-resistant E. coli infections in the U.S., especially among veterans. The activity of ceftolozane
Autor:
Matt Wasserman, Junfeng Yang, Greg Guzauskas, Yonghong Yang, Kunling Shen, Bruce C. M. Wang, Betsy Hilton, Raymond Farkouh, D Liu
Publikováno v:
PLoS ONE
PLoS ONE, Vol 13, Iss 7, p e0201245 (2018)
PLoS ONE, Vol 13, Iss 7, p e0201245 (2018)
Background The burden of pneumococcal disease in China is high, and a 13-valent pneumococcal conjugate vaccine (PCV13) recently received regulatory approval and is available to Chinese infants. PCV13 protects against the most prevalent serotypes caus
Publikováno v:
PLoS ONE
PLoS ONE, Vol 13, Iss 7, p e0200249 (2018)
PLoS ONE, Vol 13, Iss 7, p e0200249 (2018)
Background Dipeptidyl peptidase-4 (DPP-4) inhibitors may have protective effects on diabetic kidney disease (DKD) via specific antioxidant pathways. The DPP-4 inhibitor, linagliptin, was evaluated with the hypothesis that DPP-4 inhibition would ameli
Autor:
Matthew G. Ewend, Shawn Hingtgen, Onyi Okolie, Kevin Sheets, Raluca Dumitru, C. Ryan Miller, Abigail G. Carey-Ewend, Andrew Satterlee, Vivien Lettry, Scott Elton, David M. Irvin, Juli R. Bagó
Publikováno v:
PLoS ONE
PLoS ONE, Vol 13, Iss 7, p e0198596 (2018)
PLoS ONE, Vol 13, Iss 7, p e0198596 (2018)
Background Cytotoxic neural stem cells (NSCs) have emerged as a promising treatment for Medulloblastoma (MB), the most common malignant primary pediatric brain tumor. The lack of accurate pre-clinical models incorporating surgical resection and tumor
Publikováno v:
PLoS ONE
PLoS ONE, Vol 13, Iss 7, p e0199925 (2018)
PLoS ONE, Vol 13, Iss 7, p e0199925 (2018)
In this study, heparin-loaded poly-ɛ-caprolactone (PCL) fibrous mats were prepared and characterized based on their physical, cytotoxic, thermal, and biological properties. The main objective of the work described here was to test the hypothesis tha
Publikováno v:
PLoS ONE
PLoS ONE, Vol 13, Iss 7, p e0200924 (2018)
PLoS ONE, Vol 13, Iss 7, p e0200924 (2018)
The stress hormone cortisol has been recognized as a coordinator of immune response. However, its different ability to modulate the release of inflammatory mediators in males and females has not been clarified yet. Indeed, the dissection of cortisol