Zobrazeno 1 - 10
of 365
pro vyhledávání: ''
Autor:
Glenda Lassi, Maria Pino-Yanes, Somnath Mukhopadhyay, Roger Tavendale, Antonio Espuela-Ortiz, Karen Wilson, Natalia Hernandez-Pacheco, Colin N. A. Palmer, Simon Young, Steve Turner, Adam Platt, Cyrielle Maroteau, Fiona Carr, Esteban G. Burchard, Anke-Hilse Maitland-van der Zee, Esther Herrera-Luis, James D. Chalmers, Sundararajan Srinivasan
Publikováno v:
PLoS ONE, 16(9 September):e0257396. Public Library of Science
PLoS ONE
PLoS ONE, Vol 16, Iss 9, p e0257396 (2021)
PLoS ONE
PLoS ONE, Vol 16, Iss 9, p e0257396 (2021)
Leukotrienes play a central pathophysiological role in both paediatric and adult asthma. However, 35% to 78% of asthmatics do not respond to leukotriene inhibitors. In this study we tested the role of theLTA4Hregulatory variant rs2660845 and age of a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e583b11172691656d2a829454145a0c7
http://sro.sussex.ac.uk/id/eprint/101847/5/journal.pone.0257396.pdf
http://sro.sussex.ac.uk/id/eprint/101847/5/journal.pone.0257396.pdf
Publikováno v:
PLoS Pathogens
PLoS Pathogens, Vol 17, Iss 9, p e1009936 (2021)
PLoS Pathogens, Vol 17, Iss 9, p e1009936 (2021)
While Entamoeba histolytica (Eh)-induced pro-inflammatory responses are critical in disease pathogenesis, the downstream signaling pathways that subsequently dampens inflammation and the immune response remains unclear. Eh in contact with macrophages
Autor:
Connor G. G. Bamford, Milagros Rodriguez Collados, Alfredo Castello, Srikeerthana Kuchi, David Robertson, Nardus Mollentze, Sam J. Wilson, Joseph Busby, Arthur Wickenhagen, Douglas G. Stewart, Richard J. Orton, Siddharth Bakshi, Quan Gu, Elena Sugrue, Matthew L. Turnbull, Daniel G. Streicker, Massimo Palmarini, Suzannah J. Rihn, Andrew Shaw, Ana Filipe da Silva, Paul C. D. Johnson, Katherine Smollett
Publikováno v:
PLoS Biology
PLoS Biology, Vol 19, Iss 9, p e3001352 (2021)
PLoS Biology, Vol 19, Iss 9, p e3001352 (2021)
Antiviral defenses can sense viral RNAs and mediate their destruction. This presents a challenge for host cells since they must destroy viral RNAs while sparing the host mRNAs that encode antiviral effectors. Here, we show that highly upregulated int
Autor:
Pieter Steenhuis, Thi Dinh La, Zhanna Gurenko, Hsin Ya Yang, Roslyn Rivkah Isseroff, Aaron M. Glucksman
Publikováno v:
PLoS ONE
PloS one, vol 16, iss 7
PLoS ONE, Vol 16, Iss 7, p e0253139 (2021)
PloS one, vol 16, iss 7
PLoS ONE, Vol 16, Iss 7, p e0253139 (2021)
Keratinocyte migration into skin wounds is the step of the healing process that correlates with the wound closure rate. Keratinocyte migration, and wound epithelialization are decreased when beta 2-adrenergic receptors (B2AR) are activated by 1 μM e
Autor:
Oussaïma El Dbouni, Maowia M. Mukhtar, Zoubir Harrat, Yusr Saadi Ben Aoun, Nabil Haddad, Hejer Souguir, Emna Harigua-Souiai, Insaf Bel Hadj Ali, Akila Fathallah-Mili, Ikram Guizani, A. Yaacoub, Moncef Ben Said, Hamed Chouaieb
Publikováno v:
PLoS Neglected Tropical Diseases
PLoS Neglected Tropical Diseases, Vol 15, Iss 7, p e0009530 (2021)
PLoS Neglected Tropical Diseases, Vol 15, Iss 7, p e0009530 (2021)
Background Dipeptidyl peptidase III (DPPIII) member of M49 peptidase family is a zinc-dependent metallopeptidase that cleaves dipeptides sequentially from the N-terminus of its substrates. In Leishmania, DPPIII, was reported with other peptidases to
Publikováno v:
PLoS Computational Biology
PLoS Computational Biology, Vol 17, Iss 6, p e1009145 (2021)
PLoS computational biology, vol 17, iss 6
PLoS Computational Biology, Vol 17, Iss 6, p e1009145 (2021)
PLoS computational biology, vol 17, iss 6
State-dependent sodium channel blockers are often prescribed to treat cardiac arrhythmias, but many sodium channel blockers are known to have pro-arrhythmic side effects. While the anti and proarrhythmic potential of a sodium channel blocker is thoug
Autor:
Gough G. Au, Angela R. Harrison, Glenn A. Marsh, Gregory W. Moseley, Stephen M. Rawlinson, Cassandra T. David, Megan Dearnley, Diane Green, Shawn Todd
Publikováno v:
PLoS Pathogens
PLoS Pathogens, Vol 17, Iss 6, p e1009636 (2021)
PLoS Pathogens, Vol 17, Iss 6, p e1009636 (2021)
Many viruses target signal transducers and activators of transcription (STAT) 1 and 2 to antagonise antiviral interferon signalling, but targeting of signalling by other STATs/cytokines, including STAT3/interleukin 6 that regulate processes important
Autor:
Anouk Sarr, Carsten Terjung, Gabriele Schmuck, David D. Ekale, Daniel Kulke, Lucien Rufener, Vincent N. Tanya, Germanus S. Bah, John Graham-Brown, Nicolas H. Bayang, Helena Fieseler, Ralph Krebber, Steffen Hahnel, Benjamin L. Makepeace, Youssouf M. Mfopit, Sebastian Schneckener, Martin Glenschek-Sieberth, Henrietta F. Ngangyung
Publikováno v:
PLoS Pathogens
PLoS Pathogens, Vol 17, Iss 6, p e1009601 (2021)
PLOS PATHOGENS
PLoS Pathogens, Vol 17, Iss 6, p e1009601 (2021)
PLOS PATHOGENS
Onchocerciasis (river blindness), caused by the filarial worm Onchocerca volvulus, is a neglected tropical disease mostly affecting sub-Saharan Africa and is responsible for >1.3 million years lived with disability. Current control relies almost enti
Autor:
Atsuo Itakura, Satoru Takeda, Kazuko Saeki, Shintaro Makino, Takehiko Yokomizo, Mai Ohba, Nanase Takahashi, Hiroki Fujii, Masaya Takahashi, Toshiaki Okuno
Publikováno v:
PLoS ONE
PLoS ONE, Vol 16, Iss 4, p e0250638 (2021)
PLoS ONE, Vol 16, Iss 4, p e0250638 (2021)
Prostaglandin E2 (PGE2) is known to have important roles in labor, but the detailed mechanism underlying the spontaneous human labor remains unknown. Here, we examined the involvement of prostaglandin biosynthetic enzymes and transporter in the accum
Autor:
Daniël Höhle, Eric Claassen, James G. Pfaus, Frits Michiels, Jos Bloemers, Paddy K.C. Janssen, Adriaan Tuiten, Kim van Rooij
Publikováno v:
PLOS ONE, 16(3):e0246828. Public Library of Science
PLoS ONE
PLoS ONE, 16(3):e0246828, 1-14. Public Library of Science
PLoS ONE, Vol 16, Iss 3, p e0246828 (2021)
Höhle, D, van Rooij, K, Bloemers, J, Pfaus, J G, Michiels, F, Janssen, P, Claassen, E & Tuiten, A 2021, ' A survival of the fittest strategy for the selection of genotypes by which drug responders and non-responders can be predicted in small groups ', PLoS ONE, vol. 16, no. 3, e0246828, pp. 1-14 . https://doi.org/10.1371/journal.pone.0246828
PLoS ONE
PLoS ONE, 16(3):e0246828, 1-14. Public Library of Science
PLoS ONE, Vol 16, Iss 3, p e0246828 (2021)
Höhle, D, van Rooij, K, Bloemers, J, Pfaus, J G, Michiels, F, Janssen, P, Claassen, E & Tuiten, A 2021, ' A survival of the fittest strategy for the selection of genotypes by which drug responders and non-responders can be predicted in small groups ', PLoS ONE, vol. 16, no. 3, e0246828, pp. 1-14 . https://doi.org/10.1371/journal.pone.0246828
Phenotype Prediction Scores (PPS) might be powerful tools to predict traits or the efficacy of treatments based on combinations of Single-Nucleotide Polymorphism (SNPs) in large samples. We developed a novel method to produce PPS models for small sam