Zobrazeno 1 - 10
of 543
pro vyhledávání: ''
Autor:
Glenda Lassi, Maria Pino-Yanes, Somnath Mukhopadhyay, Roger Tavendale, Antonio Espuela-Ortiz, Karen Wilson, Natalia Hernandez-Pacheco, Colin N. A. Palmer, Simon Young, Steve Turner, Adam Platt, Cyrielle Maroteau, Fiona Carr, Esteban G. Burchard, Anke-Hilse Maitland-van der Zee, Esther Herrera-Luis, James D. Chalmers, Sundararajan Srinivasan
Publikováno v:
PLoS ONE, 16(9 September):e0257396. Public Library of Science
PLoS ONE
PLoS ONE, Vol 16, Iss 9, p e0257396 (2021)
PLoS ONE
PLoS ONE, Vol 16, Iss 9, p e0257396 (2021)
Leukotrienes play a central pathophysiological role in both paediatric and adult asthma. However, 35% to 78% of asthmatics do not respond to leukotriene inhibitors. In this study we tested the role of theLTA4Hregulatory variant rs2660845 and age of a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e583b11172691656d2a829454145a0c7
http://sro.sussex.ac.uk/id/eprint/101847/5/journal.pone.0257396.pdf
http://sro.sussex.ac.uk/id/eprint/101847/5/journal.pone.0257396.pdf
Autor:
Jean-René Kiechel, Borimas Hanboonkunupakarn, James Pike, Nicholas J. White, Sue J. Lee, Caterina I. Fanello, Xin Hui S Chan, Yan Naung Win, Bernhards Ogutu, Elizabeth A. Ashley, Marie A. Onyamboko, André Siqueira, Walter Rj Taylor, Ilsa L. Haeusler, Maryam Hanafiah, Marcus Vg Lacerda, Abdoulaye Djimde
Publikováno v:
PLoS Medicine, Vol 18, Iss 9, p e1003766 (2021)
PLoS Medicine
PLoS Medicine
Background Amodiaquine is a 4-aminoquinoline antimalarial similar to chloroquine that is used extensively for the treatment and prevention of malaria. Data on the cardiovascular effects of amodiaquine are scarce, although transient effects on cardiac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d315daca514bda2780eaf237c6ff48d
https://doi.org/10.1371/journal.pmed.1003766
https://doi.org/10.1371/journal.pmed.1003766
Autor:
Amrit P. Singh, Frank Schmitz, Adam Z. Rosenthal, Madhav V. Dhodapkar, Antje Hoering, Daisy Alapat, Yan Ren, Maurizio Zangari, Kelsie Smith, Samuel A. Danziger, Jake Gockley, Andrew Dervan, Alexander V. Ratushny, Mark McConnell, Robert M. Hershberg, Suzana Couto, Brian A Walker, Faith E. Davies, Alison Fitch, Wilbert B. Copeland, Gareth J. Morgan, Bart Barlogie, Phil Farmer, David J. Reiss, Brian Fox, Mary H. Young, Frits van Rhee, Cody Ashby, Katie Newhall, Nathan Petty, Michael A Bauer, Robert Z. Orlowski, Matthew Trotter
Publikováno v:
PLoS Medicine
PLoS Medicine, Vol 17, Iss 11, p e1003323 (2020)
PLoS Medicine, Vol 17, Iss 11, p e1003323 (2020)
Background The tumor microenvironment (TME) is increasingly appreciated as an important determinant of cancer outcome, including in multiple myeloma (MM). However, most myeloma microenvironment studies have been based on bone marrow (BM) aspirates, w
Autor:
Pierre Chauvin, Charles Lefevre, Julien Letheulle, Stéphane Jouneau, Bertrand De Latour, Mallorie Kerjouan, Betsega Bayeh, Pierre Tattevin, David Luque Paz, Mathieu Lederlin, Florence Poizeau
Publikováno v:
PLoS ONE
PLoS ONE, 2021, 16 (9), pp.e0257339. ⟨10.1371/journal.pone.0257339⟩
PLoS ONE, Public Library of Science, 2021, 16 (9), pp.e0257339. ⟨10.1371/journal.pone.0257339⟩
PLoS ONE, Vol 16, Iss 9, p e0257339 (2021)
PLoS ONE, 2021, 16 (9), pp.e0257339. ⟨10.1371/journal.pone.0257339⟩
PLoS ONE, Public Library of Science, 2021, 16 (9), pp.e0257339. ⟨10.1371/journal.pone.0257339⟩
PLoS ONE, Vol 16, Iss 9, p e0257339 (2021)
Introduction Evacuation of infected fluid in pleural infections is essential. To date, the use of an intrapleural fibrinolytic agent such as urokinase and DNase has not yet been assessed in infections managed by repeated therapeutic thoracentesis (RT
Autor:
Lorraine Tsitsi Pfavayi, Arnold Mutemeri, Dixon Chibanda, Francisca Mutapi, Takafira Mduluza, Derick Nii Mensah Osakunor, Rivka M. Lim, Simbarashe Rusakaniko, Maritha Kasambala
Publikováno v:
PLoS Neglected Tropical Diseases
PLoS Neglected Tropical Diseases, Vol 15, Iss 8, p e0009660 (2021)
PLoS Neglected Tropical Diseases, Vol 15, Iss 8 (2021)
Mutapi, F, Pfavayi, L T, Osakunor, D N M, Lim, R, Kasambala, M, Muemeri, A, Rusakaniko, S, Chibanda, D & Mduluza, T 2021, ' Assessing early child development and its association with stunting and schistosome infections in rural Zimbabwean children using the griffiths scales of child development ', PLoS Neglected Tropical Diseases, vol. 15, no. 8, e0009660 . https://doi.org/10.1371/journal.pntd.0009660
PLoS Neglected Tropical Diseases, Vol 15, Iss 8, p e0009660 (2021)
PLoS Neglected Tropical Diseases, Vol 15, Iss 8 (2021)
Mutapi, F, Pfavayi, L T, Osakunor, D N M, Lim, R, Kasambala, M, Muemeri, A, Rusakaniko, S, Chibanda, D & Mduluza, T 2021, ' Assessing early child development and its association with stunting and schistosome infections in rural Zimbabwean children using the griffiths scales of child development ', PLoS Neglected Tropical Diseases, vol. 15, no. 8, e0009660 . https://doi.org/10.1371/journal.pntd.0009660
There is a paucity of reference early childhood development (ECD) data at community level in rural Africa. Our objective was to conduct a comprehensive assessment of ECD in rural Zimbabwe and determine the impact of stunting and schistosome infection
Autor:
Marko Kadija, Emilija Dubljanin Raspopović, Winfried Meissner, Goran Tulic, Sanja Tomanović Vujadinović, Ruth Zaslansky
Publikováno v:
PLoS ONE
PLoS ONE, Vol 16, Iss 7, p e0253147 (2021)
PLoS ONE, Vol 16, Iss 7, p e0253147 (2021)
Introduction/Aim Early rehabilitation, return to daily life activities and function are the ultimate goals of perioperative care. It is unclear which pain-related patient-reported outcome measures (PROM) mirror treatment effects or are related with e
Autor:
George Zacharopoulos, Francesco Sella, Roi Cohen Kadosh, Kathrin Cohen Kadosh, Uzay E. Emir, Charlotte E. Hartwright
Publikováno v:
PLoS Biology
PLoS Biology, Vol 19, Iss 7, p e3001325 (2021)
PLoS Biology, Vol 19, Iss 7, p e3001325 (2021)
Previous research has highlighted the role of glutamate and gamma-aminobutyric acid (GABA) in learning and plasticity. What is currently unknown is how this knowledge translates to real-life complex cognitive abilities that emerge slowly and how the
Autor:
Jaime Altcheh, Luis Castro, Juan C Dib, Ulrike Grossmann, Erya Huang, Guillermo Moscatelli, Jimy José Pinto Rocha, Teresa Estela Ramírez, CHICO Study Group
Publikováno v:
CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET
PLoS Neglected Tropical Diseases, Vol 15, Iss 1, p e0008912 (2021)
PLoS Neglected Tropical Diseases
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET
PLoS Neglected Tropical Diseases, Vol 15, Iss 1, p e0008912 (2021)
PLoS Neglected Tropical Diseases
Nifurtimox is a recommended treatment for Chagas disease, but data from treated children are limited. We investigated the efficacy, safety and tolerability of nifurtimox administered as divisible, dispersible 30 mg and 120 mg tablets in children with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::21712d252180e11362346c2556b2f933
https://journals.plos.org/plosntds/article?id=10.1371/journal.pntd.0008912
https://journals.plos.org/plosntds/article?id=10.1371/journal.pntd.0008912
Publikováno v:
PLoS Neglected Tropical Diseases
PLoS Neglected Tropical Diseases, Vol 15, Iss 7, p e0009490 (2021)
PLoS Neglected Tropical Diseases, Vol 15, Iss 7, p e0009490 (2021)
Treatment and control of schistosomiasis depends on a single drug, praziquantel, but this is not ideal for several reasons including lack of potency against the juvenile stage of the parasite, dose size, and risk of resistance. We have optimised the
Autor:
J. P. Jones, William Parker, Caroline J. Smith, Zacharoula Konsoula, John Poulton, Jasmine Cendejas Hernandez, Navneet Suda
Publikováno v:
PLoS ONE
PLoS ONE, Vol 16, Iss 6, p e0253543 (2021)
PLoS ONE, Vol 16, Iss 6, p e0253543 (2021)
Based on several lines of evidence, numerous investigators have suggested that acetaminophen exposure during early development can induce neurological disorders. We had previously postulated that acetaminophen exposure early in life, if combined with