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Correction: Phenylephrine induces relaxation of longitudinal strips from small arteries of goat legs
Autor:
Alen Major Venis, Sathya Subramani, Soosai Manickam Amirtham, Kawin Padmaja Marconi, Renu Raj, Bhavithra Bharathi
Publikováno v:
PLoS ONE
PLoS ONE, Vol 15, Iss 3, p e0227316 (2020)
PLoS ONE, Vol 15, Iss 3, p e0227316 (2020)
Alpha adrenergic stimulation is known to produce vasoconstriction. We have earlier shown that, in spiral strips of small arteries Phenylephrine (PE) caused vasorelaxation under high nitric oxide (NO) environment. However on further experimentation it
Autor:
Pan Xiaoké, Amandeep K. Sandhu, Jurjan Aman, Etto C. Eringa, Camiel V. J. Box, Geesje M. Dallinga-Thie, Alexander H. Turaihi
Publikováno v:
PLOS ONE, 16(7):0250442. Public Library of Science
PLoS ONE, 16(7 July):e0250442. Public Library of Science
PLoS ONE
PLoS ONE, Vol 16, Iss 7, p e0250442 (2021)
Box, C V J, Sandhu, A K, Turaihi, A H, Xiaoke, P, Dallinga-Thie, G, Aman, J & Eringa, E C 2021, ' Effects of imatinib on vascular insulin sensitivity and free fatty acid transport in early weight gain ', PLoS ONE, vol. 16, no. 7 . https://doi.org/10.1371/journal.pone.0250442
PLoS ONE, 16(7). Public Library of Science
PLoS ONE, 16(7 July):e0250442. Public Library of Science
PLoS ONE
PLoS ONE, Vol 16, Iss 7, p e0250442 (2021)
Box, C V J, Sandhu, A K, Turaihi, A H, Xiaoke, P, Dallinga-Thie, G, Aman, J & Eringa, E C 2021, ' Effects of imatinib on vascular insulin sensitivity and free fatty acid transport in early weight gain ', PLoS ONE, vol. 16, no. 7 . https://doi.org/10.1371/journal.pone.0250442
PLoS ONE, 16(7). Public Library of Science
Background Vascular endothelial dysfunction is an essential part of the pathophysiology of type 2 diabetes and its complications. In type 2 diabetes, endothelial dysfunction is characterized by reduced insulin signaling and increased transendothelial
Publikováno v:
PLoS ONE
PLoS ONE, Vol 16, Iss 7, p e0254783 (2021)
PLoS ONE, Vol 16, Iss 7, p e0254783 (2021)
An array of isoforms of the nuclear estrogen receptor alpha (ER-α) protein contribute to heterogeneous response in breast cancer (BCa); yet, a single-cell analysis tool that distinguishes the full-length ER-α66 protein from the activation function-
Autor:
Pieter Steenhuis, Thi Dinh La, Zhanna Gurenko, Hsin Ya Yang, Roslyn Rivkah Isseroff, Aaron M. Glucksman
Publikováno v:
PLoS ONE
PloS one, vol 16, iss 7
PLoS ONE, Vol 16, Iss 7, p e0253139 (2021)
PloS one, vol 16, iss 7
PLoS ONE, Vol 16, Iss 7, p e0253139 (2021)
Keratinocyte migration into skin wounds is the step of the healing process that correlates with the wound closure rate. Keratinocyte migration, and wound epithelialization are decreased when beta 2-adrenergic receptors (B2AR) are activated by 1 μM e
Autor:
Oussaïma El Dbouni, Maowia M. Mukhtar, Zoubir Harrat, Yusr Saadi Ben Aoun, Nabil Haddad, Hejer Souguir, Emna Harigua-Souiai, Insaf Bel Hadj Ali, Akila Fathallah-Mili, Ikram Guizani, A. Yaacoub, Moncef Ben Said, Hamed Chouaieb
Publikováno v:
PLoS Neglected Tropical Diseases
PLoS Neglected Tropical Diseases, Vol 15, Iss 7, p e0009530 (2021)
PLoS Neglected Tropical Diseases, Vol 15, Iss 7, p e0009530 (2021)
Background Dipeptidyl peptidase III (DPPIII) member of M49 peptidase family is a zinc-dependent metallopeptidase that cleaves dipeptides sequentially from the N-terminus of its substrates. In Leishmania, DPPIII, was reported with other peptidases to
Autor:
J. P. Jones, William Parker, Caroline J. Smith, Zacharoula Konsoula, John Poulton, Jasmine Cendejas Hernandez, Navneet Suda
Publikováno v:
PLoS ONE
PLoS ONE, Vol 16, Iss 6, p e0253543 (2021)
PLoS ONE, Vol 16, Iss 6, p e0253543 (2021)
Based on several lines of evidence, numerous investigators have suggested that acetaminophen exposure during early development can induce neurological disorders. We had previously postulated that acetaminophen exposure early in life, if combined with
Publikováno v:
PLoS Computational Biology
PLoS Computational Biology, Vol 17, Iss 6, p e1009145 (2021)
PLoS computational biology, vol 17, iss 6
PLoS Computational Biology, Vol 17, Iss 6, p e1009145 (2021)
PLoS computational biology, vol 17, iss 6
State-dependent sodium channel blockers are often prescribed to treat cardiac arrhythmias, but many sodium channel blockers are known to have pro-arrhythmic side effects. While the anti and proarrhythmic potential of a sodium channel blocker is thoug
Autor:
Nermina Vejzagic, Thomas Spangenberg, Ruili Huang, Nagwa Elkhafif, Anton Simeonov, Ulrich Fabien Prodjinotho, Clarissa Prazeres da Costa
Publikováno v:
PLoS Neglected Tropical Diseases
PLoS Neglected Tropical Diseases, Vol 15, Iss 5, p e0009432 (2021)
PLoS Neglected Tropical Diseases, Vol 15, Iss 5, p e0009432 (2021)
Background Anthelminthic treatment options against schistosomiasis are limited. The current treatment relies almost exclusively on a single drug, praziquantel (PZQ). As a consequence, the development of resistance to PZQ and limited activity of PZQ a
Autor:
Allison Brashear, Stefan Wietek, Stuart Isaacson, William G. Ondo, Mark F. Lew, Pascal Maisonobe, Bruce K. Rubin, Robert A. Hauser, Khashayar Dashtipour, Atul T. Patel
Publikováno v:
PLoS ONE
PLoS ONE, Vol 16, Iss 2, p e0245827 (2021)
PLoS ONE, Vol 16, Iss 4, p e0250475 (2021)
PLoS ONE, Vol 16, Iss 2, p e0245827 (2021)
PLoS ONE, Vol 16, Iss 4, p e0250475 (2021)
Cervical dystonia (CD) is primarily treated with botulinum toxin, at intervals of ≥ 12 weeks. We present efficacy, patient-reported outcomes (PROs), and safety in adults with CD at the last available visit after a single set of abobotulinumtoxinA (
Publikováno v:
PLoS ONE
PLoS ONE, Vol 16, Iss 4, p e0249344 (2021)
PLoS ONE, Vol 16, Iss 4, p e0249344 (2021)
Purpose To examine the effect of prolactin (PRL) on human corneal stromal fibroblasts (CSFs), derived from healthy individuals and from keratoconus (KC) patients, in vitro, specifically assessing physiological and elevated PRL concentrations as appar