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Publikováno v:
PLoS ONE
PLoS ONE, Vol 16, Iss 7, p e0254783 (2021)
PLoS ONE, Vol 16, Iss 7, p e0254783 (2021)
An array of isoforms of the nuclear estrogen receptor alpha (ER-α) protein contribute to heterogeneous response in breast cancer (BCa); yet, a single-cell analysis tool that distinguishes the full-length ER-α66 protein from the activation function-
Autor:
J. P. Jones, William Parker, Caroline J. Smith, Zacharoula Konsoula, John Poulton, Jasmine Cendejas Hernandez, Navneet Suda
Publikováno v:
PLoS ONE
PLoS ONE, Vol 16, Iss 6, p e0253543 (2021)
PLoS ONE, Vol 16, Iss 6, p e0253543 (2021)
Based on several lines of evidence, numerous investigators have suggested that acetaminophen exposure during early development can induce neurological disorders. We had previously postulated that acetaminophen exposure early in life, if combined with
Autor:
Allison Brashear, Stefan Wietek, Stuart Isaacson, William G. Ondo, Mark F. Lew, Pascal Maisonobe, Bruce K. Rubin, Robert A. Hauser, Khashayar Dashtipour, Atul T. Patel
Publikováno v:
PLoS ONE
PLoS ONE, Vol 16, Iss 2, p e0245827 (2021)
PLoS ONE, Vol 16, Iss 4, p e0250475 (2021)
PLoS ONE, Vol 16, Iss 2, p e0245827 (2021)
PLoS ONE, Vol 16, Iss 4, p e0250475 (2021)
Cervical dystonia (CD) is primarily treated with botulinum toxin, at intervals of ≥ 12 weeks. We present efficacy, patient-reported outcomes (PROs), and safety in adults with CD at the last available visit after a single set of abobotulinumtoxinA (
Publikováno v:
PLoS ONE
PLoS ONE, Vol 16, Iss 4, p e0249344 (2021)
PLoS ONE, Vol 16, Iss 4, p e0249344 (2021)
Purpose To examine the effect of prolactin (PRL) on human corneal stromal fibroblasts (CSFs), derived from healthy individuals and from keratoconus (KC) patients, in vitro, specifically assessing physiological and elevated PRL concentrations as appar
Autor:
Atsuo Itakura, Satoru Takeda, Kazuko Saeki, Shintaro Makino, Takehiko Yokomizo, Mai Ohba, Nanase Takahashi, Hiroki Fujii, Masaya Takahashi, Toshiaki Okuno
Publikováno v:
PLoS ONE
PLoS ONE, Vol 16, Iss 4, p e0250638 (2021)
PLoS ONE, Vol 16, Iss 4, p e0250638 (2021)
Prostaglandin E2 (PGE2) is known to have important roles in labor, but the detailed mechanism underlying the spontaneous human labor remains unknown. Here, we examined the involvement of prostaglandin biosynthetic enzymes and transporter in the accum
Autor:
Daniël Höhle, Eric Claassen, James G. Pfaus, Frits Michiels, Jos Bloemers, Paddy K.C. Janssen, Adriaan Tuiten, Kim van Rooij
Publikováno v:
PLOS ONE, 16(3):e0246828. Public Library of Science
PLoS ONE
PLoS ONE, 16(3):e0246828, 1-14. Public Library of Science
PLoS ONE, Vol 16, Iss 3, p e0246828 (2021)
Höhle, D, van Rooij, K, Bloemers, J, Pfaus, J G, Michiels, F, Janssen, P, Claassen, E & Tuiten, A 2021, ' A survival of the fittest strategy for the selection of genotypes by which drug responders and non-responders can be predicted in small groups ', PLoS ONE, vol. 16, no. 3, e0246828, pp. 1-14 . https://doi.org/10.1371/journal.pone.0246828
PLoS ONE
PLoS ONE, 16(3):e0246828, 1-14. Public Library of Science
PLoS ONE, Vol 16, Iss 3, p e0246828 (2021)
Höhle, D, van Rooij, K, Bloemers, J, Pfaus, J G, Michiels, F, Janssen, P, Claassen, E & Tuiten, A 2021, ' A survival of the fittest strategy for the selection of genotypes by which drug responders and non-responders can be predicted in small groups ', PLoS ONE, vol. 16, no. 3, e0246828, pp. 1-14 . https://doi.org/10.1371/journal.pone.0246828
Phenotype Prediction Scores (PPS) might be powerful tools to predict traits or the efficacy of treatments based on combinations of Single-Nucleotide Polymorphism (SNPs) in large samples. We developed a novel method to produce PPS models for small sam
Autor:
S. J. Van Schyndel, J. Rousseau, B. Mion, O. Bogado Pascottini, J. F. W. Sprícigo, J. S. Weese, Stephen J. LeBlanc
Publikováno v:
PLoS ONE
PLoS ONE, Vol 16, Iss 2, p e0233943 (2021)
PLOS ONE
PLoS ONE, Vol 16, Iss 2, p e0233943 (2021)
PLOS ONE
This study evaluated the effects of treatment with meloxicam (a non-steroidal anti-inflammatory drug), parity, and blood progesterone concentration on the dynamics of the uterine microbiome of clinically healthy postpartum dairy cows. Seven primiparo
Publikováno v:
PLoS ONE
PLoS ONE, Vol 16, Iss 2, p e0246213 (2021)
PLoS ONE, Vol 16, Iss 2, p e0246213 (2021)
Despite the need for safe and effective postoperative analgesia in neonates, research regarding pain management in neonatal rodents is relatively limited. Here, we investigate whether sustained release buprenorphine (Bup SR) effectively attenuates th
Autor:
Yemisi Dorcas Obafemi, Akinniyi Paul Akinduti, Joshua Adekunle Osiyemi, Adewale Gideon Adeyemi, Oluwaseun Ejilude, Temitope Temitayo Banjo, Maged El-Ashker, Patrick Omoregie Isibor
Publikováno v:
PLoS ONE
PLoS ONE, Vol 16, Iss 2, p e0247013 (2021)
PLoS ONE, Vol 16, Iss 2, p e0247013 (2021)
Spread of genetically diverse Staphylococcus aureus characterized with multi-antibiotic resistance and regulated by high level agr functionalities in several communities in southwest Nigeria was investigated and evaluated for infection control. Staph
Autor:
Pradnya Dilip Chandanshive, Rashmi Ranjan Mohanty, Shree Ram Singh, Biswa Mohan Padhy, Somen Kumar Pradhan, Prasanta Raghab Mohapatra, Priyamadhaba Behera, Ravikumar S R, Arvind Kumar Singh, Binod Kumar Patro, Gitanjali Batmanabane, Shakti Kumar Bal, Siva Santosh Kumar Pentapati
Publikováno v:
PLoS ONE
PLoS ONE, Vol 16, Iss 2, p e0247163 (2021)
PLoS ONE, Vol 16, Iss 2, p e0247163 (2021)
Background Ivermectin is one among several potential drugs explored for its therapeutic and preventive role in SARS-CoV-2 infection. The study was aimed to explore the association between ivermectin prophylaxis and the development of SARS-CoV-2 infec