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Autor:
Oussaïma El Dbouni, Maowia M. Mukhtar, Zoubir Harrat, Yusr Saadi Ben Aoun, Nabil Haddad, Hejer Souguir, Emna Harigua-Souiai, Insaf Bel Hadj Ali, Akila Fathallah-Mili, Ikram Guizani, A. Yaacoub, Moncef Ben Said, Hamed Chouaieb
Publikováno v:
PLoS Neglected Tropical Diseases
PLoS Neglected Tropical Diseases, Vol 15, Iss 7, p e0009530 (2021)
PLoS Neglected Tropical Diseases, Vol 15, Iss 7, p e0009530 (2021)
Background Dipeptidyl peptidase III (DPPIII) member of M49 peptidase family is a zinc-dependent metallopeptidase that cleaves dipeptides sequentially from the N-terminus of its substrates. In Leishmania, DPPIII, was reported with other peptidases to
Autor:
Nermina Vejzagic, Thomas Spangenberg, Ruili Huang, Nagwa Elkhafif, Anton Simeonov, Ulrich Fabien Prodjinotho, Clarissa Prazeres da Costa
Publikováno v:
PLoS Neglected Tropical Diseases
PLoS Neglected Tropical Diseases, Vol 15, Iss 5, p e0009432 (2021)
PLoS Neglected Tropical Diseases, Vol 15, Iss 5, p e0009432 (2021)
Background Anthelminthic treatment options against schistosomiasis are limited. The current treatment relies almost exclusively on a single drug, praziquantel (PZQ). As a consequence, the development of resistance to PZQ and limited activity of PZQ a
Autor:
Robert N. Kelsh, Jennifer P Owen
Publikováno v:
PLoS ONE
PLoS ONE, Vol 16, Iss 3, p e0246504 (2021)
PLoS ONE, Vol 16, Iss 3, p e0246504 (2021)
Zebrafish are frequently used as a means to investigate development. These studies increasingly require repeated anaesthesia of zebrafish during juvenile (i.e. metamorphic) stages. The effects of anaesthesia during this time remain poorly studied. Th
Autor:
S. J. Van Schyndel, J. Rousseau, B. Mion, O. Bogado Pascottini, J. F. W. Sprícigo, J. S. Weese, Stephen J. LeBlanc
Publikováno v:
PLoS ONE
PLoS ONE, Vol 16, Iss 2, p e0233943 (2021)
PLOS ONE
PLoS ONE, Vol 16, Iss 2, p e0233943 (2021)
PLOS ONE
This study evaluated the effects of treatment with meloxicam (a non-steroidal anti-inflammatory drug), parity, and blood progesterone concentration on the dynamics of the uterine microbiome of clinically healthy postpartum dairy cows. Seven primiparo
Autor:
Paksathorn Kietsiri, Ladaporn Bodhidatta, Samandra T. Demons, Woradee Lurchachaiwong, Orasa Suthienkul, Norman C. Waters, Paphavee Lertsethtakarn, Chonchanok Muangnapoh, Brian Vesely
Publikováno v:
PLoS ONE
PLoS ONE, Vol 16, Iss 2, p e0246598 (2021)
PLoS ONE, Vol 16, Iss 2, p e0246598 (2021)
Arcobacter butzleri is an emerging zoonotic food-borne and water-borne pathogen that can cause diarrhea in humans. The global prevalence of A. butzleri infection is underestimated, and little is known about their phenotypic and genotypic characteriza
Autor:
Mirriam Ethel Nyenje, Mwangala Lonah Akapelwa, Stephen V. Gordon, Aki Tamaru, Eddie Samuneti Solo, Jeewan Thapa, Yasuhiko Suzuki, Bernard Mudenda Hang' ombe, Kyoko Hayashida, Precious Bwalya, Chie Nakajima, Musso Munyeme, Thoko Flav Kapalamula
Publikováno v:
PLoS Neglected Tropical Diseases
PLoS Neglected Tropical Diseases, Vol 15, Iss 1, p e0008996 (2021)
PLoS Neglected Tropical Diseases, Vol 15, Iss 1, p e0008996 (2021)
Bovine tuberculosis (TB) caused by Mycobacterium bovis is a significant health threat to cattle and a zoonotic threat for humans in many developing countries. Rapid and accurate detection of M. bovis is fundamental for controlling the disease in anim
Autor:
Simone L. Reynolds, Malcolm K. Jones, Nicolas Ortonne, Katja Fischer, Deepani D. Fernando, Bernard Cribier, Gunter Hartel
Publikováno v:
PLoS Neglected Tropical Diseases
PLoS Neglected Tropical Diseases, Vol 15, Iss 1, p e0008997 (2021)
PLoS Neglected Tropical Diseases, Vol 15, Iss 1, p e0008997 (2021)
Background Scabies, a highly contagious skin disease affecting more than 200 million people worldwide at any time, is caused by the parasitic mite Sarcoptes scabiei. In the absence of molecular markers, diagnosis requires experience making surveillan
Autor:
Yang Xiaowen, Guozhong Tian, Tonglei Wu, Wenxiao Liu, Dongri Piao, Hai Jiang, Qingmin Wu, Hongyan Zhao
Publikováno v:
PLoS Neglected Tropical Diseases
PLoS Neglected Tropical Diseases, Vol 14, Iss 12, p e0008888 (2020)
PLoS Neglected Tropical Diseases, Vol 14, Iss 12, p e0008888 (2020)
Brucella spp. are facultative intracellular pathogens that can persistently colonize host cells and cause the zoonosis- brucellosis. The WHO recommended a treatment for brucellosis that involves a combination of doxycycline, rifampicin, or streptomyc
Autor:
Pratchakan Chaiyachat, Ditthawat Nonghanphithak, Kiatichai Faksri, Angkana Chaiprasert, Wipa Reechaipichitkul, Orawee Kaewprasert
Publikováno v:
PLoS ONE
PLoS ONE, Vol 15, Iss 12, p e0244829 (2020)
PLoS ONE, Vol 15, Iss 12, p e0244829 (2020)
Drug resistance (DR) remains a major challenge for tuberculosis (TB) control. Whole-genome sequencing (WGS) provides the highest genetic resolution for genotypic drug-susceptibility tests (DST). We compared DST profiles of 60 Mycobacterium tuberculos
Autor:
Isabel S. Shiratsubaki, Ariel Mariano Silber, Jair L. Siqueira-Neto, Bernhard O. Palsson, Rodolpho Ornitz Oliveira Souza, Xin Fang
Publikováno v:
PLoS Neglected Tropical Diseases
Shiratsubaki, I S, Fang, X, Souza, R O O, Palsson, B O, Silber, A M & Siqueira-Neto, J L 2020, ' Genome-scale metabolic models highlight stage-specific differences in essential metabolic pathways in Trypanosoma cruzi ', PLOS Neglected Tropical Diseases, vol. 14, no. 10, e0008728 . https://doi.org/10.1371/journal.pntd.0008728
PLoS Neglected Tropical Diseases, Vol 14, Iss 10, p e0008728 (2020)
PLoS neglected tropical diseases, vol 14, iss 10
Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
Shiratsubaki, I S, Fang, X, Souza, R O O, Palsson, B O, Silber, A M & Siqueira-Neto, J L 2020, ' Genome-scale metabolic models highlight stage-specific differences in essential metabolic pathways in Trypanosoma cruzi ', PLOS Neglected Tropical Diseases, vol. 14, no. 10, e0008728 . https://doi.org/10.1371/journal.pntd.0008728
PLoS Neglected Tropical Diseases, Vol 14, Iss 10, p e0008728 (2020)
PLoS neglected tropical diseases, vol 14, iss 10
Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
Chagas disease is a neglected tropical disease and a leading cause of heart failure in Latin America caused by a protozoan called Trypanosoma cruzi. This parasite presents a complex multi-stage life cycle. Anti-Chagas drugs currently available are li