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Publikováno v:
PLoS ONE
PLoS ONE, Vol 16, Iss 7, p e0254783 (2021)
PLoS ONE, Vol 16, Iss 7, p e0254783 (2021)
An array of isoforms of the nuclear estrogen receptor alpha (ER-α) protein contribute to heterogeneous response in breast cancer (BCa); yet, a single-cell analysis tool that distinguishes the full-length ER-α66 protein from the activation function-
Autor:
Atsuo Itakura, Satoru Takeda, Kazuko Saeki, Shintaro Makino, Takehiko Yokomizo, Mai Ohba, Nanase Takahashi, Hiroki Fujii, Masaya Takahashi, Toshiaki Okuno
Publikováno v:
PLoS ONE
PLoS ONE, Vol 16, Iss 4, p e0250638 (2021)
PLoS ONE, Vol 16, Iss 4, p e0250638 (2021)
Prostaglandin E2 (PGE2) is known to have important roles in labor, but the detailed mechanism underlying the spontaneous human labor remains unknown. Here, we examined the involvement of prostaglandin biosynthetic enzymes and transporter in the accum
Autor:
A. Abakar Mahamat, N. Mathé, Roger Faroux, R. Boustany, P. Soulié, L. Moreau, Isabelle Baumgaertner, R. Hervé, J. M. Phelip, D. Smith, J. M. Bons, L. Vazquez, Laurent Miglianico, Eric Francois, Rosine Guimbaud, Laurent Mineur, Louis-Marie Dourthe, A. L. Villing, S. Remy, E. Achille, N. Bonichon, Carine Plassot, I. Rabbia
Publikováno v:
PLoS ONE
PLoS ONE, Vol 15, Iss 12, p e0243997 (2020)
PLoS ONE, Vol 15, Iss 12, p e0243997 (2020)
Background Cetuximab improves progression-free survival (PFS) and overall survival (OS) in patients with KRAS wild type (wt) metastatic colorectal cancer (mCRC). Few data are available on factors impacting both efficacy and compliance to cetuximab tr
Autor:
Megan A Palmer, Khalidah Ibraheem, Myria Ioannou, Andrew Collett, Michael Peake, Christopher Dunnill, Nikolaos T. Georgopoulos, Adrian Smith
Publikováno v:
PLoS ONE
PLoS ONE, Vol 15, Iss 10, p e0240454 (2020)
PLoS ONE, Vol 15, Iss 10, p e0240454 (2020)
Chemotherapy-induced alopecia (CIA) represents the most distressing side-effect for cancer patients. Scalp cooling is currently the only treatment to combat CIA, yet little is known about its cytoprotective effects in human hair follicles (HF). We ha
Autor:
Maria Di Bari, María Elena Sales, Alejandro Javier Español, Yamila Sanchez, Ada Maria Tata, Agustina Reina Salem, Ilaria Cristofaro
Publikováno v:
PLoS ONE
PLoS ONE, Vol 15, Iss 9, p e0226450 (2020)
CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET
PLoS ONE, Vol 15, Iss 9, p e0226450 (2020)
CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET
Triple negative tumors are more aggressive than other breast cancer subtypes and there is a lack of specific therapeutic targets on them. Since muscarinic receptors have been linked to tumor progression, we investigated the effect of metronomic thera
Autor:
Laila Silamikele, Davids Fridmanis, Valdis Pirags, Monta Ustinova, Laura Ansone, Vita Rovite, Ilze Konrade, Janis Klovins, Ilze Elbere, Jelizaveta Sokolovska, Ivars Silamikelis, Ineta Kalnina
Publikováno v:
PLoS ONE
PLoS ONE, Vol 15, Iss 8, p e0237400 (2020)
PLoS ONE, Vol 15, Iss 8, p e0237400 (2020)
Metformin, a biguanide agent, is the first-line treatment for type 2 diabetes mellitus due to its glucose-lowering effect. Despite its wide application in the treatment of multiple health conditions, the glycemic response to metformin is highly varia
Autor:
Nassim Ledoux, William-Naud Gauthier, Pauline Adjibade, Edouard W. Khandjian, Bryan Simoneau, Rachid Mazroui, Melisse Nkurunziza
Publikováno v:
PLoS ONE
PLoS ONE, Vol 15, Iss 5, p e0231894 (2020)
PLoS ONE, Vol 15, Iss 5, p e0231894 (2020)
Stress granules (SG) are cytoplasmic RNA granules that form during various types of stress known to inhibit general translation, including oxidative stress, hypoxia, endoplasmic reticulum stress (ER), ionizing radiations or viral infection. Induction
Autor:
Arif Kodza, Rakesh K. Singh, Kyu Kwang Kim, Aaron Jones, Rachael Turner, Richard G. Moore, Negar Khazan
Publikováno v:
PLoS ONE
PLoS ONE, Vol 15, Iss 5, p e0232253 (2020)
PLoS ONE, Vol 15, Iss 5, p e0232253 (2020)
Proteases have been implicated in the tumorigenesis and aggressiveness of a variety of cancer types. In fact, proteases have proven to be very clinically useful as tumor biomarkers in the blood of patients. Proteases are typically involved in complex
Autor:
Daniela Dettori, Jéssica Zani Lacerda, Daniela Taverna, Lívia Carvalho Ferreira, Francesca Orso, Debora Aparecida Pires de Campos Zuccari, Thaiz F. Borin
Publikováno v:
PLoS ONE
Web of Science
Repositório Institucional da UNESP
Universidade Estadual Paulista (UNESP)
instacron:UNESP
PLoS ONE, Vol 15, Iss 2, p e0228062 (2020)
Web of Science
Repositório Institucional da UNESP
Universidade Estadual Paulista (UNESP)
instacron:UNESP
PLoS ONE, Vol 15, Iss 2, p e0228062 (2020)
Made available in DSpace on 2020-12-10T19:59:34Z (GMT). No. of bitstreams: 0 Previous issue date: 2020-02-03 Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) Melatonin, a hormone secreted by pineal gland, exerts antimetastatic effect
Autor:
J.M. Galbis, Javier Alcácer, José Javier Martín de Llano, María Oliver, Carmen Carda, Manuel de la Mata, María Sancho-Tello, Julian Carretero, Lara Milian, Carlos Camps
Publikováno v:
PLoS ONE
PLoS One
r-FISABIO: Repositorio Institucional de Producción Científica
Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana (FISABIO)
r-FISABIO. Repositorio Institucional de Producción Científica
instname
PLoS ONE, Vol 15, Iss 2, p e0228909 (2020)
r-INCLIVA. Repositorio Institucional de Producción Científica de INCLIVA
PLoS One
r-FISABIO: Repositorio Institucional de Producción Científica
Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana (FISABIO)
r-FISABIO. Repositorio Institucional de Producción Científica
instname
PLoS ONE, Vol 15, Iss 2, p e0228909 (2020)
r-INCLIVA. Repositorio Institucional de Producción Científica de INCLIVA
Background/Objective Patients with non-small cell lung cancer (NSCLC) develop resistance to antitumor agents by mechanisms that involve the epithelial-to-mesenchymal transition (EMT). This necessitates the development of new complementary drugs, e.g.