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Autor:
J. P. Jones, William Parker, Caroline J. Smith, Zacharoula Konsoula, John Poulton, Jasmine Cendejas Hernandez, Navneet Suda
Publikováno v:
PLoS ONE
PLoS ONE, Vol 16, Iss 6, p e0253543 (2021)
PLoS ONE, Vol 16, Iss 6, p e0253543 (2021)
Based on several lines of evidence, numerous investigators have suggested that acetaminophen exposure during early development can induce neurological disorders. We had previously postulated that acetaminophen exposure early in life, if combined with
Autor:
Allison Brashear, Stefan Wietek, Stuart Isaacson, William G. Ondo, Mark F. Lew, Pascal Maisonobe, Bruce K. Rubin, Robert A. Hauser, Khashayar Dashtipour, Atul T. Patel
Publikováno v:
PLoS ONE
PLoS ONE, Vol 16, Iss 2, p e0245827 (2021)
PLoS ONE, Vol 16, Iss 4, p e0250475 (2021)
PLoS ONE, Vol 16, Iss 2, p e0245827 (2021)
PLoS ONE, Vol 16, Iss 4, p e0250475 (2021)
Cervical dystonia (CD) is primarily treated with botulinum toxin, at intervals of ≥ 12 weeks. We present efficacy, patient-reported outcomes (PROs), and safety in adults with CD at the last available visit after a single set of abobotulinumtoxinA (
Autor:
Daniël Höhle, Eric Claassen, James G. Pfaus, Frits Michiels, Jos Bloemers, Paddy K.C. Janssen, Adriaan Tuiten, Kim van Rooij
Publikováno v:
PLOS ONE, 16(3):e0246828. Public Library of Science
PLoS ONE
PLoS ONE, 16(3):e0246828, 1-14. Public Library of Science
PLoS ONE, Vol 16, Iss 3, p e0246828 (2021)
Höhle, D, van Rooij, K, Bloemers, J, Pfaus, J G, Michiels, F, Janssen, P, Claassen, E & Tuiten, A 2021, ' A survival of the fittest strategy for the selection of genotypes by which drug responders and non-responders can be predicted in small groups ', PLoS ONE, vol. 16, no. 3, e0246828, pp. 1-14 . https://doi.org/10.1371/journal.pone.0246828
PLoS ONE
PLoS ONE, 16(3):e0246828, 1-14. Public Library of Science
PLoS ONE, Vol 16, Iss 3, p e0246828 (2021)
Höhle, D, van Rooij, K, Bloemers, J, Pfaus, J G, Michiels, F, Janssen, P, Claassen, E & Tuiten, A 2021, ' A survival of the fittest strategy for the selection of genotypes by which drug responders and non-responders can be predicted in small groups ', PLoS ONE, vol. 16, no. 3, e0246828, pp. 1-14 . https://doi.org/10.1371/journal.pone.0246828
Phenotype Prediction Scores (PPS) might be powerful tools to predict traits or the efficacy of treatments based on combinations of Single-Nucleotide Polymorphism (SNPs) in large samples. We developed a novel method to produce PPS models for small sam
Autor:
Robert N. Kelsh, Jennifer P Owen
Publikováno v:
PLoS ONE
PLoS ONE, Vol 16, Iss 3, p e0246504 (2021)
PLoS ONE, Vol 16, Iss 3, p e0246504 (2021)
Zebrafish are frequently used as a means to investigate development. These studies increasingly require repeated anaesthesia of zebrafish during juvenile (i.e. metamorphic) stages. The effects of anaesthesia during this time remain poorly studied. Th
Publikováno v:
PLoS ONE
PLoS ONE, Vol 16, Iss 2, p e0246213 (2021)
PLoS ONE, Vol 16, Iss 2, p e0246213 (2021)
Despite the need for safe and effective postoperative analgesia in neonates, research regarding pain management in neonatal rodents is relatively limited. Here, we investigate whether sustained release buprenorphine (Bup SR) effectively attenuates th
Autor:
Fois, Adrien, Boucher-Lafleur, Anne-Marie, Thompson Legault, Julie, Renaud, Christian, Morin, Charles, Des Rosiers, Christine, Coderre, Lise, Laprise, Catherine, Lesage, Sylvie, LSFC Consortium
Publikováno v:
PLoS ONE
PLoS ONE, Vol 15, Iss 10, p e0239860 (2020)
PLoS ONE, Vol 15, Iss 10, p e0239860 (2020)
Leigh Syndrome French Canadian (LSFC) is a rare autosomal recessive metabolic disorder characterized by severe lactic acidosis crises and early mortality. LSFC patients carry mutations in the Leucine Rich Pentatricopeptide Repeat Containing (LRPPRC)
Publikováno v:
PLoS ONE
PLoS ONE, Vol 15, Iss 9, p e0238208 (2020)
PLoS ONE, Vol 15, Iss 9, p e0238208 (2020)
IntroductionPeripheral nerve injury (PNI) often leads to significant functional loss in patients and poses a challenge to physicians since treatment options for improving functional outcomes are limited. Recent studies suggest that erythropoietin and
Autor:
Nashwa W. Yassa, Doaa A. Ghareeb, Sofia Khalil, Samar R. Saleh, Maha A. El Demellawy, Mohamed M. El-Sayed
Publikováno v:
PLoS ONE
PLoS ONE, Vol 15, Iss 8, p e0237929 (2020)
PLoS ONE, Vol 15, Iss 8, p e0237929 (2020)
BackgroundNeuroinflammation causes neurodegenerative conditions like Alzheimer's disease (AD). Ipriflavone (IP), therapeutic compound to postmenopausal osteoporosis, has limited estrogenic activity and is accounted as AChE inhibitor. The developing o
Publikováno v:
PLoS ONE
PLoS ONE, Vol 15, Iss 7, p e0236318 (2020)
PLoS ONE, Vol 15, Iss 7, p e0236318 (2020)
Lately, Drosophila has been favored as a model in sleep and circadian rhythm research due to its conserved mechanism and easily manageable operation. These studies have revealed the sophisticated parameters in whole-day sleep profiles of Drosophila,
Autor:
Adriano Wang-Leandro, Katrin Beckmann, Aline R Steiner, Sven Haller, Inés Carrera, Matthias Dennler, Henning Richter, Rima N Bektas
Publikováno v:
PLoS ONE
PLoS ONE, Vol 15, Iss 4, p e0231955 (2020)
PLOS ONE, Vol. 15, No 4 (2020) P. e0231955
PLoS ONE, Vol 15, Iss 4, p e0231955 (2020)
PLOS ONE, Vol. 15, No 4 (2020) P. e0231955
Resting-state functional Magnetic Resonance Imaging (rs-fMRI) has become an established technique in humans and reliably determines several resting state networks (RSNs) simultaneously. Limited data exist about RSN in dogs. The aim of this study was