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Publikováno v:
PLoS ONE
PLoS ONE, Vol 15, Iss 9 (2020)
PLoS ONE, Vol 15, Iss 9, p e0238184 (2020)
PLoS ONE, Vol 15, Iss 9 (2020)
PLoS ONE, Vol 15, Iss 9, p e0238184 (2020)
Pneumocystis pneumonia (PCP) is an opportunistic and potentially life-threatening infection of AIDS patients caused by the fungus Pneumocystis jirovecii (P. jirovecii). Trimethoprim-sulfamethoxazole (TMP-SMX) is the most commonly used drug combinatio
Autor:
Hon S. Leong, Paul C. Boutros, James C. Lacefield, Matthew R. Lowerison, Alessandro Datti, Joe S. Mymryk, Kara M. Ruicci, John W. Barrett, Stephenie D. Prokopec, Kevin Fung, Karlee Searle, Frederick S. Vizeacoumar, Nicole Pinto, Anthony C. Nichols, Danielle MacNeil, John Yoo
Publikováno v:
PLoS ONE
Anatomy and Cell Biology Publications
PloS one, vol 13, iss 11
PLoS ONE, Vol 13, Iss 11, p e0207152 (2018)
Anatomy and Cell Biology Publications
PloS one, vol 13, iss 11
PLoS ONE, Vol 13, Iss 11, p e0207152 (2018)
Anaplastic thyroid cancer (ATC) is a rare and lethal human malignancy with no known effective therapies in the majority of cases. Despite the use of conventional treatments such as chemotherapy, radiation and surgical resection, this disease remains
Autor:
Brandon J. Ausk, Ted S. Gross, Edith M. Gardiner, Leah E. Worton, Steven D. Bain, Ronald Y. Kwon, Leah M. Downey
Publikováno v:
PLoS ONE
PLoS ONE, Vol 13, Iss 11, p e0207354 (2018)
PLoS ONE, Vol 13, Iss 11, p e0207354 (2018)
At sufficient dose, intramuscular injection of Botulinum toxin A causes muscle wasting that is physiologically consistent with surgical denervation and other types of neuromuscular dysfunction. The aim of this study was to clarify early molecular and
Publikováno v:
PLoS ONE
PLoS ONE, Vol 13, Iss 11, p e0207027 (2018)
PLoS ONE, Vol 13, Iss 11, p e0207027 (2018)
Opioids are widely used for treating different types of pains, but overuse and abuse of prescription opioids have led to opioid epidemic in the United States. Besides analgesic effects, chronic use of opioid can also cause tolerance, dependence, and
Autor:
John G.T. Augoustides, Elizabeth Mahanna-Gabrielli, Cecilia Kim, Todd A. Miano, Joseph E. Bavaria, W. Andrew Kofke
Publikováno v:
PLoS ONE
PLoS ONE, Vol 13, Iss 11, p e0207941 (2018)
PLoS ONE, Vol 13, Iss 11, p e0207941 (2018)
Introduction Patients undergoing cardiac surgery are at high risk for postoperative delirium, which is associated with longer hospital and intensive care lengths of stays, increased morbidity and mortality. Because sleep disturbances are common in de
Publikováno v:
PLoS ONE
PLoS ONE, Vol 13, Iss 11, p e0207750 (2018)
PLoS ONE, Vol 13, Iss 11, p e0207750 (2018)
N-(4-fluorophenyl)-N'-phenyl-N"-(pyrimidin-2-ylmethyl)-1,3,5-triazine-2,4,6-triamine [ASP2905] is a potent and selective inhibitor of the potassium voltage-gated channel subfamily H member 3 (KCNH3) that was originally identified in our laboratory. K
Autor:
Yi Yu, Peter E. Kima, Naixin Zhang, Neil E. Reiner, Stella Chen, Devki Nandan, Brian Schwartz
Publikováno v:
PLoS ONE
PLoS ONE, Vol 13, Iss 11, p e0206920 (2018)
PLoS ONE, Vol 13, Iss 11, p e0206920 (2018)
Leishmaniasis is amongst the most important neglected diseases, afflicting more than 12 million people in 88 countries. There is an urgent need for safe orally bioavailable and cost-effective drugs for the treatment of leishmaniasis. It has recently
Publikováno v:
PLoS ONE
PLoS ONE, Vol 13, Iss 11, p e0207210 (2018)
PLoS ONE, Vol 13, Iss 11, p e0207210 (2018)
Type 2 diabetes (T2D) is a complex metabolic disease associated with alterations in glucose, lipid and protein metabolism. In order to characterize the biochemical phenotype of the Zucker diabetic fatty (ZDF) rat, the most common animal model for the
Autor:
Jake Moscarelli, Z. Ping Lin, Yong-Lian Zhu, Ying-Chun Lo, Smith Giri, Amy Xiong, Elena Ratner, Pamela H Huang, Yasmin Korayem, Patricia LoRusso
Publikováno v:
PLoS ONE
PLoS ONE, Vol 13, Iss 11, p e0207399 (2018)
PLoS ONE, Vol 13, Iss 11, p e0207399 (2018)
PARP inhibitors target BRCA mutations and defective homologous recombination repair (HRR) for the treatment of epithelial ovarian cancer (EOC). However, the treatment of HRR-proficient EOC with PARP inhibitors remains challenging. The objective of th
Autor:
Julie-Anne A. Tangena, Phoutmany Thammavong, Paul T. Brey, Somsanith Chonephetsarath, Kouxiong Sayteng, Ian W. Sutherland, Sébastien Marcombe, Marc Grandadam, Steve W. Lindsay, Boudsady Somphong
Publikováno v:
PLoS ONE, 2018, Vol.13(10), pp.e0206387 [Peer Reviewed Journal]
PLoS ONE
PLoS ONE, Vol 13, Iss 10, p e0206387 (2018)
PLoS ONE
PLoS ONE, Vol 13, Iss 10, p e0206387 (2018)
In the last four decades there has been a staggering increase in the geographical range of the arboviral vector Aedes albopictus (Skuse, 1894). This species is now found in every continent except Antarctica, increasing the distribution of arboviral d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d0468c23eccf9961ea8805fdb79f81ff
https://doi.org/10.1371/journal.pone.0206387
https://doi.org/10.1371/journal.pone.0206387