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Autor:
Solomon H. Snyder, Hidenori Hattori, Hongbo R. Luo, Whaseon Lee-Kwon, Eiichiro Nagata, Mark Donowitz, Mir Ahamed Hossain, Lynda D. Hester, Yunfei Huang
Publikováno v:
Proceedings of the National Academy of Sciences. 100:11712-11717
Protein kinase B/Akt possesses prosurvival and antiapoptotic activities and is involved in growth factor-mediated neuronal protection. In this study we establish Akt deactivation as a causal mediator of cell death. Akt deactivation occurs in multiple