Zobrazeno 1 - 10
of 16
pro vyhledávání: '"James P. Allison"'
Autor:
Jianjun Gao, Hao Zhao, Rebecca S. S. Tidwell, Emily Z. Keung, Yuji Miura, Salahaldin A. Tahir, Sumit K. Subudhi, Hussein Abdul-Hassan Tawbi, Jennifer A. Wargo, James P. Allison, Padmanee Sharma, Jorge Blando
Publikováno v:
Proceedings of the National Academy of Sciences. 116:22246-22251
Immune checkpoint (IC) therapy provides substantial benefits to cancer patients but can also cause distinctive toxicities termed immune-related adverse events (irAEs). Biomarkers to predict toxicities will be necessary to improve management of patien
Autor:
Todd Bartkowiak, K. Jagannadha Sastry, Guojun Yang, Shailbala Singh, Michael A. Curran, Dhwani Haria, Midan Ai, James P. Allison, G Galvan
Publikováno v:
Proceedings of the National Academy of Sciences. 112
Antibody modulation of T-cell coinhibitory (e.g., CTLA-4) or costimulatory (e.g., 4-1BB) receptors promotes clinical responses to a variety of cancers. Therapeutic cancer vaccination, in contrast, has produced limited clinical benefit and no curative
Autor:
Gerd Ritter, Jedd D. Wolchok, Mario Sznol, Teresa S. Rasalan, Sacha Gnjatic, Lloyd J. Old, Ruth Halaban, Stephanie L. Terzulli, Humilidad F. Gallardo, Evelina Pogoriler, Deborah Kuk, Jianda Yuan, Matthew Adamow, Brian A. Ginsberg, Achim A. Jungbluth, Katherine S. Panageas, James P. Allison, Yinyan Xu, Erika Ritter
Publikováno v:
Proceedings of the National Academy of Sciences. 108:16723-16728
Ipilimumab, a monoclonal antibody against cytotoxic T lymphocyte antigen 4 (CTLA-4), has been shown to improve survival in patients with advanced metastatic melanoma. It also enhances immunity to NY-ESO-1, a cancer/testis antigen expressed in a subse
Publikováno v:
Proceedings of the National Academy of Sciences. 107:4275-4280
Vaccination with irradiated B16 melanoma cells expressing either GM-CSF (Gvax) or Flt3-ligand (Fvax) combined with antibody blockade of the negative T-cell costimulatory receptor cytotoxic T-lymphocyte antigen-4 (CTLA-4) promotes rejection of preimpl
Autor:
Achim A. Jungbluth, Lloyd J. Old, Gerd Ritter, Geoffrey Y. Ku, Yinyan Xu, Teresa S. Rasalan, Erika Ritter, Ruth Ann Roman, James P. Allison, Humilidad F. Gallardo, Melanie Heywood, Jedd D. Wolchok, Hao Li, Neil H. Segal, Evelina Pogoriler, Sacha Gnjatic, Sarah Powel, Gregor Manukian, Jianda Yuan, Stephanie L. Terzulli
Publikováno v:
Proceedings of the National Academy of Sciences. 105:20410-20415
Blockade of inhibitory signals mediated by cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) has been shown to enhance T cell responses and induce durable clinical responses in patients with metastatic melanoma. The functional impact of anti-CTLA-
Autor:
James P. Allison, Nilabh Shastri, Norman M. Greenberg, Tae Rim, Rebecca Waitz, Lawrence Fong, Marcella Fasso, Yafei Hou
Publikováno v:
Proceedings of the National Academy of Sciences. 105:3509-3514
Discovery of immunologically relevant antigens in prostate cancer forms the basis for developing more potent active immunotherapy. We report here a strategy using the transgenic adenocarcinoma of mouse prostate (TRAMP) model, which allows for the fun
Autor:
Michael T. Jaklitsch, Frank G. Haluska, Marybeth Nelson, Sara Russell, James P. Allison, Darryl A. Oble, Alan J. Korman, Glenn Dranoff, Nikhil H. Ramaiya, F. Stephen Hodi, Suzanne MacRae, Christine Canning, Israel Lowy, Donna Neuberg, Teresa C. Chen, David B. Lautz, Martin C. Mihm, Marcus O. Butler, Michael V. Seiden, Andrea Kruse
Publikováno v:
Proceedings of the National Academy of Sciences. 105:3005-3010
Cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) functions as a negative regulator of endogenous and vaccine-induced antitumor immunity. The administration of fully human anti-CTLA-4 blocking monoclonal antibodies to advanced-cancer patients incr
Publikováno v:
Proceedings of the National Academy of Sciences. 104:17765-17770
Despite the importance of programmed death-1 (PD-1) for T cell inhibition, little is known about its intracellular trafficking or requirements for localization to the immunological synapse. Here, we show that in activated T cells, PD-1 is present at
Autor:
James P. Allison, P'ng Loke
Publikováno v:
Proceedings of the National Academy of Sciences. 100:5336-5341
PD-L1 and PD-L2 are ligands for PD-1, a costimulatory molecule that plays an inhibitory role in regulating T cell activation in the periphery. We find that PD-L1 is highly expressed on inflammatory macrophages as compared with resident peritoneal mac
Publikováno v:
Proceedings of the National Academy of Sciences. 99:3013-3017
We and others previously reported that cytotoxic T lymphocyte antigen-4 (CTLA-4) regulates the severity of peptide-induced experimental autoimmune encephalomyelitis (EAE) in mouse strains that are inherently susceptible to the disease. In this report