Zobrazeno 1 - 6
of 6
pro vyhledávání: '"David L. Huso"'
Autor:
Guosheng Liu, Jian Yang, J. Michael McCaffery, Bert Vogelstein, Kenneth W. Kinzler, William P.D. Hendricks, David L. Huso, Shibin Zhou
Publikováno v:
Proceedings of the National Academy of Sciences. 110:14717-14722
Nanoparticle gene therapy holds great promise for the treatment of malignant disease in light of the large number of potent, tumor-specific therapeutic payloads potentially available for delivery. To be effective, gene therapy vehicles must be able t
Autor:
Amy Hacker-Prietz, Robert A. Casero, David L. Huso, Shervin Rabizadeh, Patrick M. Woster, Cynthia L. Sears, Andrew C. Goodwin, Xin Qun Wu, Christina E. DeStefano Shields, Shaoguang Wu, Tracy Murray-Stewart
Publikováno v:
Proceedings of the National Academy of Sciences. 108:15354-15359
It is estimated that the etiology of 20–30% of epithelial cancers is directly associated with inflammation, although the direct molecular events linking inflammation and carcinogenesis are poorly defined. In the context of gastrointestinal disease,
Autor:
David L. Huso, Clare Bao, Baktiar O. Karim, Ralph H. Hruban, Munekazu Yamakuchi, Joshua T. Mendell, Charles J. Lowenstein, Craig Lotterman
Publikováno v:
Proceedings of the National Academy of Sciences. 107:6334-6339
The pathway involving the tumor suppressor gene TP53 can regulate tumor angiogenesis by unclear mechanisms. Here we show that p53 regulates hypoxic signaling through the transcriptional regulation of microRNA-107 (miR-107). We found that miR-107 is a
Publikováno v:
Proceedings of the National Academy of Sciences. 107:4664-4668
IFN-regulatory factor 5 (IRF-5), a member of the IRF family, is a transcription factor that has a key role in the induction of the antiviral and inflammatory response. When compared with C57BL/6 mice, Irf5 −/− mice show higher susceptibility to v
Autor:
Weiping Qiu, Akash Nanda, Brad St. Croix, Zhongsheng Peng, Baktiar O. Karim, Bert Vogelstein, Kenneth W. Kinzler, Guosheng Liu, Christine Gan, David L. Huso
Publikováno v:
Proceedings of the National Academy of Sciences. 103:3351-3356
Tumor endothelial marker 1 ( Tem1 ; endosialin ) is the prototypical member of a family of genes expressed in the stroma of tumors. To assess the functional role of Tem1 , we disrupted the Tem1 gene in mice by targeted homologous recombination. Tem1
Autor:
David L. Huso, Ross A. Abrams, E. Latice Watson, Kenneth W. Kinzler, Chetan Bettegowda, Shibin Zhou, Ian Cheong, Nishant Agrawal, Larry E. Dillehay, J. Michael McCaffery, Bert Vogelstein, Scott Borzillary, Fred Bunz, Martin G. Pomper, Long H. Dang, Kwamena E. Baidoo, Kuo-Shyan Lin
Publikováno v:
Proceedings of the National Academy of Sciences. 100:15083-15088
The low level of oxygenation within tumors is a major cause of radiation treatment failures. We theorized that anaerobic bacteria that can selectively destroy the hypoxic regions of tumors would enhance the effects of radiation. To test this hypothes