Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Andres J. Klein-Szanto"'
Autor:
Fangxian Sun, Aleister J. Saunders, Phyllis A. Gimotty, Andres J. Klein-Szanto, Qihong Huang, Kiranmai Gumireddy, Peter G. Schultz, Jonathan M. Gibbins
Publikováno v:
Proceedings of the National Academy of Sciences. 104:6696-6701
Here, we report the identification of a metastasis promoting factor by a forward genetic screen in mice. A retroviral cDNA library was introduced into the nonmetastatic cancer cell line 168FARN, which was then orthotopically transplanted into mouse m
Autor:
Daniel E. Bassi, Stanley Zucker, Haleh Mahloogi, Ricardo Lopez de Cicco, Gary Thomas, Andres J. Klein-Szanto
Publikováno v:
Proceedings of the National Academy of Sciences. 98:10326-10331
Pro-protein convertases such as furin are expressed in many human tumor lines and primary tumors. Furin processes stromelysin-3, membrane type 1 matrix metalloproteinase (MMPs) involved in tumor cell invasiveness, as well as growth factors such as tr
Autor:
Kenneth D. Tartof, Alfred G. Knudson, Maria Vilensky, Darrell Q. Brown, Jerome J. Freed, Okio Hino, Raymond S. Yeung, Andres J. Klein-Szanto, Joseph R. Testa
Publikováno v:
Proceedings of the National Academy of Sciences. 90:327-331
Hereditary renal carcinoma (RC) in the rat, originally reported by R. Eker in 1954, is an example of a Mendelian dominant predisposition to a specific cancer in an experimental animal. At the histologic level, RCs develop through multiple stages from
Autor:
Andres J. Klein-Szanto, Beatrice Mintz
Publikováno v:
Proceedings of the National Academy of Sciences. 89:11421-11425
Eye tumors of the retinal pigment epithelium (RPE) have been thought generally to be benign, whereas choroidal ones are malignant. To test this assumption in mice, the W/Wv (Kit) mutant genotype was introduced into melanoma-prone transgenic mice whos
Publikováno v:
Proceedings of the National Academy of Sciences. 88:164-168
Ocular and cutaneous melanomas arose in new inbred lines of transgenic mice having an integrated recombinant gene comprised of the tyrosinase promoter, expressed in pigment cells, and the simian virus 40 early-region transforming sequences. The tumor