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pro vyhledávání: '"Akihisa Kato"'
Autor:
Akihisa Kato, Yasuhiro Yamagishi, Noriyuki Okawa, Mitsue Taniyama, Chinami Bando, Akira Kaji, Toshimi Morita
Publikováno v:
Proceedings of the National Academy of Sciences. 94:3324-3329
A serious drawback of tumor necrosis factor α (TNF) as a clinical antitumor agent is that it also has hypotensive activity. To overcome this problem, derivatives of its sister cytokine lymphotoxin (TNF-β or LT) were prepared. One of them, mutein 2