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Publikováno v:
Proceedings of the National Academy of Sciences. 107:20115-20119
Sexually dimorphic nociception and opioid antinociception is very pervasive but poorly understood. We had demonstrated that spinal morphine antinociception in females, but not males, requires the concomitant activation of spinal μ- and κ-opioid rec
Autor:
Raafat P. Fares, Amor Belmeguenai, Béatrice Georges, Robert A. Levine, Marion Le-Cavorsin, Chantal Bonnet, Colette Moulin, Pascal E. Sanchez, Jean-Marc Pequignot, Anne Morales, Laurent Bezin, Jacques Bodennec, Jean-Jacques Risso, Sandrine Bouvard, Etienne-Emile Baulieu
Publikováno v:
Proceedings of the National Academy of Sciences. 106:9848-9853
Erythropoietin receptor (EpoR) binding mediates neuroprotection by endogenous Epo or by exogenous recombinant human (rh)Epo. The level of EpoR gene expression may determine tissue responsiveness to Epo. Thus, harnessing the neuroprotective power of E
Publikováno v:
Proceedings of the National Academy of Sciences. 104:13501-13506
Valproic acid (VPA) is a powerful teratogen causing birth defects in humans, including autism spectrum disorder (ASD), if exposure occurs during the first trimester of embryogenesis. Learning and memory alterations are common symptoms of ASD, but und
Autor:
Robert Langer, Steven R. Little, Elena Choleris, Jessica A. Mong, Sidharth V. Puram, Donald W. Pfaff
Publikováno v:
Proceedings of the National Academy of Sciences. 104:4670-4675
Social recognition constitutes the basis of social life. In male mice and rats, social recognition is known to be governed by the neuropeptide oxytocin (OT) through its action on OT receptors (OTRs) in the medial amygdala. In female rats and mice, wh
Autor:
Mei Li, M. Zhou, Richard Wilker Korsmeyer, Bruce Allen Lefker, Thomas A. Owen, Thomas A. Brown, F. Dumont, D.D. Thompson, Slobodan Vukicevic, P. Krasney, Vishwas M. Paralkar, R.L. Dunn, Fran Borovečki, William A. Grasser, Kimberly O. Cameron, D. Plowchalk, Hua Zhu Ke, Paul DaSilva-Jardine
Publikováno v:
Proceedings of the National Academy of Sciences. 100:6736-6740
The morbidity and mortality associated with impaired/delayed fracture healing remain high. Our objective was to identify a small nonpeptidyl molecule with the ability to promote fracture healing and prevent malunions. Prostaglandin E 2 (PGE 2 ) cause
Publikováno v:
Proceedings of the National Academy of Sciences. 99:4686-4691
Using on-line microdialysis, we have characterized in vivo dynamics of pineal 5-hydroxytryptamine (5-HT; serotonin) release. Daily pineal 5-HT output is triphasic: ( i ) 5-HT levels are constant and high during the day; ( ii ) early in the night, the
Publikováno v:
Proceedings of the National Academy of Sciences. 94:14054-14059
Insulin-like growth factors-I and -II (IGF-I and -II) are structurally related mitogenic polypeptides with potent growth promoting effects. These peptides and their corresponding IGF-I and -II receptors are selectively localized in the brain. To date
Autor:
Wuyi Kong, Nigel W. Bunnett, Lev M. Khitin, Morley D. Hollenberg, Karen McConalogue, Donald G. Payan, Stephan K. Böhm
Publikováno v:
Proceedings of the National Academy of Sciences. 94:8884-8889
Proteinase-activated receptor 2 (PAR-2) is a recently characterized G-protein coupled receptor that is cleaved and activated by pancreatic trypsin. Trypsin is usually considered a digestive enzyme in the intestinal lumen. We examined the hypothesis t
Autor:
Carola Severi, Shih-Che Huang, G. Delle Fave, Kirk P. Fortune, J. D. Gardner, Venugopal D. Talkad, Sreenivasa Jonnalagadda
Publikováno v:
Proceedings of the National Academy of Sciences. 92:10312-10316
We found that a variety of cholecystokinin (CCK) receptor ligands bind to bovine serum albumin (BSA). This binding was rapid, fully reversible, temperature independent, of low affinity, and specific for BSA; it depended on the concentration of BSA, t
Publikováno v:
Proceedings of the National Academy of Sciences. 92:7575-7579
The drive on respiration mediated by the peripheral arterial chemoreceptors was assessed by the hyperoxic test in 3-day-old rat pups. They accounted for 22.5 +/- 8.8% during control conditions, but only for 6.9 +/- 10.0% after nicotine exposure, an e