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Autor:
Anthony Letai, Stephen J. Lippard, John M. Replogle, Angelika Amon, Jeremy Ryan, James M. McFarland, Wen Zhou, Adrianna E. Amaro, Jason M. Sheltzer, Mariana Villalobos-Ortiz, Uri Ben-David, Ömer H. Yilmaz
Publikováno v:
Proc Natl Acad Sci U S A
Aneuploidy, defined as whole chromosome gains and losses, is associated with poor patient prognosis in many cancer types. However, the condition causes cellular stress and cell cycle delays, foremost in G1 and S phase. Here, we investigate how aneupl
Publikováno v:
Proceedings of the National Academy of Sciences. 117:30699-30709
In recent years, the prevalence of carbapenem-resistant Enterobacteriaceae (CRE) has risen substantially, and the study of CRE resistance mechanisms has become increasingly important for antibiotic development. Although much research has focused on g
Autor:
Rolf Müller, Robert Landick, Mirjana Lilic, Jennifer Herrmann, Rachel A. Mooney, Hande Boyaci, Elizabeth A. Campbell, Nathaniel Braffman, James Chen, Seth A. Darst, Elizabeth A. Hubin
Publikováno v:
Proceedings of the National Academy of Sciences. 117:30423-30432
Rifampicin (Rif) is a first-line therapeutic used to treat the infectious disease tuberculosis (TB), which is caused by the pathogen Mycobacterium tuberculosis (Mtb). The emergence of Rif-resistant (RifR) Mtb presents a need for new antibiotics. Rif
Autor:
Peng Liang, Hao Sun, Cheng-Liang Huang, Chang An Wang, Wei Hsuan Hung, Hung Chun Tai, Guanzhou Zhu, Jiachen Li, Michael Angell, Hongjie Dai, Yongtao Meng, Yuan-Yao Li
Publikováno v:
Proc Natl Acad Sci U S A
Potassium secondary batteries are contenders of next-generation energy storage devices owing to the much higher abundance of potassium than lithium. However, safety issues and poor cycle life of K metal battery have been key bottlenecks. Here we repo
Autor:
Michael A. Ochsenkühn, Kristin C. Gunsalus, Miraflor P. Santos, Ahmed A. Shibl, Ashley Isaac, Gregory Behringer, Shady A. Amin, Cong Fei, Marc Arnoux, Christian R. Voolstra, Anny Cárdenas, Nizar Drou
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Significance Phytoplankton are major primary producers in the marine environment that excrete a wide range of metabolites. These exudates support the growth of surrounding bacteria that in turn provide phytoplankton cells with resources and growth co
Publikováno v:
Proc Natl Acad Sci U S A
The structure of lincomycin A consists of the unusual eight-carbon thiosugar core methyllincosamide (MTL) decorated with a pendent N-methylprolinyl moiety. Previous studies on MTL biosynthesis have suggested GDP-ᴅ-erythro-α-ᴅ-gluco-octose and GD
Publikováno v:
Proc Natl Acad Sci U S A
Melatonin (Mel) promotes sleep through G protein-coupled receptors. However, the downstream molecular target(s) is unknown. We identified the Caenorhabditis elegans BK channel SLO-1 as a molecular target of the Mel receptor PCDR-1-. Knockout of pcdr-
Autor:
Elena Ivanova, Connie H Wong, Bang V. Bui, Gene Venables, Samuel A Mills, Michael A Dixon, Flora Hui, Zheng He, Kirstan A. Vessey, Vickie Hy Wong, Josh Tonc, James C Young, Botir T. Sagdullaev, Andrew I Jobling, Ursula Greferath, Erica L. Fletcher, Joanna A. Phipps
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Significance This work identifies a role for microglia, the innate immune cells of the CNS, in the local control of the retinal vasculature and identifies deficits early in diabetes. Microglia contact neurons and vasculature and express several vasoa
Autor:
Abhishek Singh, Xinbo Zhang, Qian Li, Bonne M Thompson, Yajaira Suárez, Jeffrey G McDonald, Jose Ordovas-Montanes, Carlos Fernández-Hernando, Rolando García Milian, Wen Ding, Elisa Araldi, Alberto Canfrán-Duque, Binod Aryal, Emily L. Goldberg, Yuhua Fan, Vishwa Deep Dixit, George Tellides, Elina Ikonen
Publikováno v:
Proc Natl Acad Sci U S A
Cholesterol biosynthetic intermediates, such as lanosterol and desmosterol, are emergent immune regulators of macrophages in response to inflammatory stimuli or lipid overloading, respectively. However, the participation of these sterols in regulatin
Autor:
Xiaorui Xing, Yun Zhu, Lei Cao, Chun Chan, Guoliang Zhu, Xiangxi Wang, Minnan Yang, Guoliang Yin, Fei Sun, Linhua Tai, Cheng-Feng Qin, Zihe Rao
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Significance Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a severe threat to public health and the global economy. Its spike protein is responsible for the membrane fusion and is thus a major target for vaccine and drug development