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Autor:
Jörg Striessnig
Publikováno v:
Proceedings of the National Academy of Sciences. 115:12848-12850
In PNAS, Nieto-Rostro et al. (1) report a mouse model expressing CaV2.2 (N-type) voltage-gated Ca2+ channels (VGCCs) with an extracellularly accessible hemagglutinin (HA) epitope tag engineered into their pore-forming CaV2.2 α1 subunits (i.e., CaV2.
Autor:
Sesha Manuguri, Mingdi Yan, Olof Ramström, Bin Wu, Giampiero Proietti, Sheng Xie, Yang Zhang, A. Ken Inge, Daniel Hall, Ying Fu, Joakim Romson
Publikováno v:
Proceedings of the National Academy of Sciences. 114:8464-8469
We report the modular formulation of ciprofloxacin-based pure theranostic nanodrugs that display enhanced antibacterial activities, as well as aggregation-induced emission (AIE) enhancement that was successfully used to image bacteria. The drug deriv
Autor:
Yixin Li, Lian Duan, Taicheng An, Yuemeng Ji, Nicholas P. Levitt, Mario J. Molina, Renyi Zhang, Hajime Terazono, Kentaro Misawa, Yuan Wang, Jeremiah Secrest, Yun Lin, Xidan Feng, Fang Zhang, Bowen Pan, Jun Zhao, Annie L. Zhang, Kazuhiko Shibuya, Wilmarie Marrero-Ortiz, Jianfei Peng
Publikováno v:
Proceedings of the National Academy of Sciences. 114:8169-8174
Photochemical oxidation of aromatic hydrocarbons leads to tropospheric ozone and secondary organic aerosol (SOA) formation, with profound implications for air quality, human health, and climate. Toluene is the most abundant aromatic compound under ur
Publikováno v:
Proceedings of the National Academy of Sciences. 114:6948-6953
The DNA mismatch repair (MMR) pathway recognizes and repairs errors in base pairing and acts to maintain genome stability. Cancers that have lost MMR function are common and comprise an important clinical subtype that is resistant to many standard of
Publikováno v:
Proceedings of the National Academy of Sciences. 114:4811-4815
Malignant hyperthermia (MH) is a clinical syndrome of skeletal muscle that presents as a hypermetabolic response to volatile anesthetic gases, where susceptible persons may develop lethally high body temperatures. Genetic predisposition mainly arises
Autor:
Katherine O’Flaherty, Elizabeth A. Ashley, Rosanna Powell, Takafumi Tsuboi, Christine Langer, Michael J. Malloy, Julie A. Simpson, Mayfong Mayxay, Mehul Dhorda, Pharath Lim, Ricardo Ataíde, François Nosten, Rick M. Fairhurst, Sasithon Pukrittayakamee, Jo-Anne Chan, Chanaki Amaratunga, Eizo Takashima, M. Abul Faiz, Arjen M. Dondorp, Tran Tinh Hien, Nicholas P. J. Day, Ye Htut, Freya J. I. Fowkes, James G. Beeson, Nicholas J. White
Publikováno v:
Proceedings of the National Academy of Sciences. 114:3515-3520
Artemisinin-resistant falciparum malaria, defined by a slow-clearance phenotype and the presence of kelch13 mutants, has emerged in the Greater Mekong Subregion. Naturally acquired immunity to malaria clears parasites independent of antimalarial drug
Autor:
Jie Zhang, Mengxing Chen, Rong Yan, Yang Zhang, Miao Jiang, Zhenyu Li, Jingluan Tian, Changgeng Ruan, Lili Zhao, Renping Hu, Qingya Cui, Yiwen Zhang, Sudan He, Kesheng Dai, Jian Zhang
Publikováno v:
Proceedings of the National Academy of Sciences. 114:2964-2969
Previous studies have shown that receptor-interacting protein kinase 3 (RIP3) is involved in many important biological processes, including necroptosis, apoptosis, and inflammation. Here we show that RIP3 plays a critical role in regulating platelet
Autor:
Chad R. Frasier, Miriam H. Meisler, Heather A. O'Malley, Lori L. Isom, Luis F. Lopez-Santiago, Jacy L. Wagnon, Jacob M. Hull, Yukun Yuan
Publikováno v:
Proceedings of the National Academy of Sciences. 114:2383-2388
Patients with early infantile epileptic encephalopathy (EIEE) experience severe seizures and cognitive impairment and are at increased risk for sudden unexpected death in epilepsy (SUDEP). EIEE13 [Online Mendelian Inheritance in Man (OMIM) # 614558]
Autor:
Annabel Wilz, Chun-Cheih Chao, Jessica E. Kenison, Jack P. Antel, Veit Rothhammer, Luke M. Healy, Maisa C. Takenaka, Emily C. Tjon, Francisco J. Quintana, Kalil Alves de Lima, Manon Blain, Davis M. Borucki
Publikováno v:
Proceedings of the National Academy of Sciences. 114:2012-2017
Multiple sclerosis (MS) is an autoimmune inflammatory demyelinating disease of the CNS that causes disability in young adults as a result of the irreversible accumulation of neurological deficits. Although there are potent disease-modifying agents fo
Publikováno v:
Goesten, M G, Hoffmann, R, Bickelhaupt, F M & Hensen, E J M 2017, ' Eight-coordinate fluoride in a silicate double-four-ring ', Proceedings of the National Academy of Sciences of the United States of America, vol. 114, no. 5, pp. 828-833 . https://doi.org/10.1073/pnas.1615742114
Proceedings of the National Academy of Sciences of the United States of America (PNAS), 114(5). National Academy of Sciences
Proceedings of the National Academy of Sciences USA, 114, 5, pp. 828-833
Proceedings of the National Academy of Sciences USA, 114, 828-833
Proceedings of the National Academy of Sciences of the United States of America, 114(5), 828-833. National Acad Sciences
Proceedings of the National Academy of Sciences of the United States of America (PNAS), 114(5). National Academy of Sciences
Proceedings of the National Academy of Sciences USA, 114, 5, pp. 828-833
Proceedings of the National Academy of Sciences USA, 114, 828-833
Proceedings of the National Academy of Sciences of the United States of America, 114(5), 828-833. National Acad Sciences
Significance Although strain and bonding are often antagonists in chemistry, they may also work together. When fluoride enters a silicate double-four-ring (D4R), their conjoined effect leads to fluoride binding to 8 silicon atoms. The strain comes fr