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Autor:
Helen N. Schwerdt, Ann M. Graybiel, Robert Langer, Satoko Amemori, Simon Hong, Ken-ichi Amemori, Patrick L. Tierney, Daniel J. Gibson, Tomoko Yoshida, Hideki Shimazu, Michael J. Cima
Publikováno v:
Proceedings of the National Academy of Sciences. 114:13260-13265
Many debilitating neuropsychiatric and neurodegenerative disorders are characterized by dopamine neurotransmitter dysregulation. Monitoring subsecond dopamine release accurately and for extended, clinically relevant timescales is a critical unmet nee
Autor:
Neringa Stankeviciute, Yonatan M. Kupchik, Alexander C.W. Smith, Cassandra D. Gipson, Kathryn J. Reissner, Megan E. Hensley-Simon, Peter W. Kalivas
Publikováno v:
Proceedings of the National Academy of Sciences. 110:9124-9129
Nicotine abuse and addiction is a major health liability. Nicotine, an active alkaloid in tobacco, is self-administered by animals and produces cellular adaptations in brain regions associated with drug reward, such as the nucleus accumbens. However,
Autor:
Chen-Hua Liu, Tai-Chung Tseng, Ding-Shinn Chen, Chi-Ling Chen, Pei-Jer Chen, Tung-Hung Su, Chun-Jen Liu, Te-Tien Ting, Jia-Horng Kao
Publikováno v:
Proceedings of the National Academy of Sciences. 110:7844-7849
MicroRNA-122 (miR-122) facilitates hepatitis C virus replication in vitro. Serum miR-122 has been implicated as a biomarker for various liver diseases; however, its role in chronic hepatitis C remains unclear. To address this issue, 126 patients with
Autor:
Gianna M. Fote, Mattis B. Wigestrand, Adetokunbo Obayemi, Alice M. Li, Cali A. Calarco, Marina R. Picciotto, Yann S. Mineur
Publikováno v:
Proceedings of the National Academy of Sciences. 110:3573-3578
Symptoms of depression can be induced in humans through blockade of acetylcholinesterase (AChE) whereas antidepressant-like effects can be produced in animal models and some clinical trials by limiting activity of acetylcholine (ACh) receptors. Thus,
Autor:
Davinder Hayreh, Jungsu Kim, Whitney D. Goebel, Mark A. Mintun, Deborah K. Verges, John C. Morris, Anshul Sathyan, John R. Cirrito, Brianne M. Disabato, Tammie L.S. Benzinger, Hyejin Yoon, Gina D'Angelo, Jessica L. Restivo, Yvette I. Sheline
Publikováno v:
Proceedings of the National Academy of Sciences. 108:14968-14973
Aggregation of amyloid-β (Aβ) as toxic oligomers and amyloid plaques within the brain appears to be the pathogenic event that initiates Alzheimer's disease (AD) lesions. One therapeutic strategy has been to reduce Aβ levels to limit its accumulati
Autor:
Christian Scheurer, Petros Papastogiannidis, Melanie Maurer, Lin Zhou, Yuanqing Tang, Jacques Chollet, Sergio Wittlin, Karen L. White, Tien Nguyen, William N. Charman, Yuxiang Dong, Michael Campbell, Jonathan L. Vennerstrom, J. Carl Craft, Sarah Arbe-Barnes, Heinrich Urwyler, Hugues Matile, Ian Bathurst, Kamaraj Sriraghavan, Susan A. Charman, Darren J. Creek, Xiaofang Wang, Francis C. K. Chiu, Lukas Stingelin, David M. Shackleford, Reto Brun, Julia Morizzi
Publikováno v:
Proceedings of the National Academy of Sciences. 108:4400-4405
Ozonide OZ439 is a synthetic peroxide antimalarial drug candidate designed to provide a single-dose oral cure in humans. OZ439 has successfully completed Phase I clinical trials, where it was shown to be safe at doses up to 1,600 mg and is currently
Autor:
Zhu Chen, Chuanfeng Wu, Samuel Waxman, Wen Wu, Yuan Fang Liu, Hui Ping Sun, Qiu Sheng Chen, Jiong Hu, Arthur Zelent, Yong Mei Zhu, Fang Xu, J. Li, Zhao Wl, Zhen Yi Wang, Wei Tang, Guang-Biao Zhou, Zhi Xiang Shen, Bing Chen, Sai Juan Chen
Publikováno v:
Proceedings of the National Academy of Sciences. 106:3342-3347
All- trans retinoic acid (ATRA)/arsenic trioxide (ATO) combination-based therapy has benefitted newly diagnosed acute promyelocytic leukemia (APL) in short-term studies, but the long-term efficacy and safety remained unclear. From April 2001, we have
Autor:
Jay L. Zweier, Giuseppe Ambrosio, Lawrence J. Druhan, Roberto Biondi, Arturo J. Cardounel, Cristian Dumitrescu, Yong Xia
Publikováno v:
Proceedings of the National Academy of Sciences. 104:15081-15086
Coronary vasodilation is impaired in the postischemic heart with a loss of endothelial nitric oxide synthase (eNOS) activity, but the mechanisms underlying ischemia-induced eNOS dysfunction are not understood. For nitric oxide (NO) synthesis, eNOS re
Publikováno v:
Proceedings of the National Academy of Sciences. 104:12312-12317
The molecular mechanism of desensitization of soluble guanylyl cyclase (sGC), the NO receptor, has long remained unresolved. Posttranslational modification and redox state have been postulated to affect sGC sensitivity to NO but evidence has been lac
Publikováno v:
Proceedings of the National Academy of Sciences. 104:1015-1020
The current testing of anti-HIV drugs is hampered by the lack of a small animal that is readily available and easy to handle; can be infected systemically with HIV type 1 (HIV-1); harbors the major HIV-1 target cells in a physiological frequency, org