Zobrazeno 1 - 10
of 294
pro vyhledávání: ''
Autor:
Abhishek Singh, Xinbo Zhang, Qian Li, Bonne M Thompson, Yajaira Suárez, Jeffrey G McDonald, Jose Ordovas-Montanes, Carlos Fernández-Hernando, Rolando García Milian, Wen Ding, Elisa Araldi, Alberto Canfrán-Duque, Binod Aryal, Emily L. Goldberg, Yuhua Fan, Vishwa Deep Dixit, George Tellides, Elina Ikonen
Publikováno v:
Proc Natl Acad Sci U S A
Cholesterol biosynthetic intermediates, such as lanosterol and desmosterol, are emergent immune regulators of macrophages in response to inflammatory stimuli or lipid overloading, respectively. However, the participation of these sterols in regulatin
Autor:
Randall T. Hayden, Jose Ferrolino, Daniel R. Evans, Daria Van Tyne, Jason W. Rosch, Joshua Wolf, Anh N. Vo, Gabriela Maron, Gayatri Shankar Chilambi, Michael S. Gilmore, Hayley R. Nordstrom
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Significance Immunocompromised patients are at increased risk for multidrug-resistant infections, due to broad-spectrum antibiotic exposure and a host environment with limited innate defenses. This study explored how vancomycin-resistant Enterococcus
Autor:
Mohammad-Zaman Nouri, Tingting Wang, Zhentian Lei, Saurav J. Sarma, Barbara W. Sumner, R. Michael Roberts, Sixue Chen, Ashish Jain, Jiude Mao, Ning Zhu, Nathan J. Bivens, Cheryl S. Rosenfeld, Geetu Tuteja, Nancy D. Denslow, Lloyd W. Sumner, Jin Koh
Publikováno v:
Proc Natl Acad Sci U S A
Placental trophoblast cells are potentially at risk from circulating endocrine-disrupting chemicals, such as bisphenol A (BPA). To understand how BPA and the reputedly more inert bisphenol S (BPS) affect the placenta, C57BL6J mouse dams were fed 200
Autor:
Max Bastian, Milena Hasan, Anja Ullrich, Brigitte David-Watine, Stefan Schülke, Spencer Louis Shorte, Bianca Walber, Christel Kamp, Laura Roßmann, Anna-Lisa Gerards, Tharshana Stephen, Ger van Zandbergen, Ingo Spreitzer, Katrin Bagola
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Proceedings of the National Academy of Sciences of the United States of America, 2021, 118 (39), pp.1073-1081. ⟨10.1073/pnas.2103651118⟩
Proceedings of the National Academy of Sciences of the United States of America, 118(39):e2103651118
Proceedings of the National Academy of Sciences of the United States of America, 2021, 118 (39), pp.1073-1081. ⟨10.1073/pnas.2103651118⟩
Proceedings of the National Academy of Sciences of the United States of America, 118(39):e2103651118
Significance Vaccines profit from the addition of adjuvants to better and more specifically initiate, amplify, and shape immune responses. Although the number of adjuvant candidates has steadily increased, peaking in the current SARS-CoV-2 pandemic,
Autor:
Mark Troll, Antonio J. Pagán, Nguyen Duc Bang, Rajan Troll, Lalita Ramakrishnan, David M. Tobin, Paul H. Edelstein, Roger Sewell, Nguyen Hoan Phu, Nguyen Thuy Thuong Thuong, Guy E. Thwaites, Laura Whitworth, Francisco J. Roca
Publikováno v:
Proc Natl Acad Sci U S A
Adjunctive treatment with antiinflammatory corticosteroids like dexamethasone increases survival in tuberculosis meningitis. Dexamethasone responsiveness associates with a C/T variant in Leukotriene A4 Hydrolase (LTA4H), which regulates expression of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d37878b23fe82738b7f4ccbf45b273d7
Autor:
Amanda M. Dann, Alexandra M. Moore, Lei Zhou, Rana Riahi, Timothy R. Donahue, Razmik Ghukasyan, Thuc Le, Jing Cui, Kristina Pagano, David W. Dawson, Soumya Poddar, Caius G. Radu, Keke Liang, Alice Yu, Nanping Wu, Evan R. Abt, Nooneh Khachatourian, Luyi Li, Stephanie K. Kim, Irmina A. Elliott
Publikováno v:
Proc Natl Acad Sci U S A
Proceedings of the National Academy of Sciences of the United States of America, vol 118, iss 8
Proceedings of the National Academy of Sciences of the United States of America, vol 118, iss 8
Emerging evidence suggests that intratumoral interferon (IFN) signaling can trigger targetable vulnerabilities. A hallmark of pancreatic ductal adenocarcinoma (PDAC) is its extensively reprogrammed metabolic network, in which nicotinamide adenine din
Autor:
Joshay A. Ford, Yimu Yang, Eric P. Schmidt, Sarah A. McMurtry, Kaori Oshima, Xing Zhang, Jian Liu, Ke Xia, Paco S. Herson, Xiaorui Han, Sarah M. Haeger, Yongmei Xu, Joseph A. Hippensteel, Mario J. Perez, Robert J. Linhardt
Publikováno v:
Proceedings of the National Academy of Sciences. 116:9208-9213
Sepsis induces heparanase-mediated degradation of the endothelial glycocalyx, a heparan sulfate-enriched endovascular layer critical to vascular homeostasis, releasing highly sulfated domains of heparan sulfate into the circulation. These domains are
Autor:
Kimberly A. Toops, Nilsa La Cunza, Li Xuan Tan, Timothy A. Blenkinsop, Aparna Lakkaraju, Colin J. Germer, Gulpreet Kaur, Marie Fernandes, Gurugirijha Rathnasamy
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America, vol 115, iss 36
Abnormally enlarged early endosomes (EEs) are pathological features of neurodegenerative diseases, yet insight into the mechanisms and consequences of EE expansion remains elusive. Here, we report swollen apical EEs in the retinal pigment epithelium
Autor:
Moshe Arditi, Roberta A. Gottlieb, Timothy R. Crother, Yang Song, Fayyaz S. Sutterwala, Shuang Chen, Gantsetseg Tumurkhuu, Andrea Dorfleutner, Rojo A. Ratsimandresy, Malcolm Lane, Stefanie Marek-Iannucci, Suzanne L. Cassel, Jessica Carriere, Ivet Bahar, Jargalsaikhan Dagvadorj, Karolina Mikulska-Ruminska, Allen M. Andres, Christian Stehlik
Publikováno v:
Proc Natl Acad Sci U S A
The balance between NLRP3 inflammasome activation and mitophagy is essential for homeostasis and cellular health, but this relationship remains poorly understood. Here we found that interleukin-1α (IL-1α)–deficient macrophages have reduced caspas
Autor:
Namrata R. Chowdhury, Brieann C. Satterfield, Rajendra P. Gajula, Elena Skornyakov, Kenneth I. Porter, Benita Middleton, Shobhan Gaddameedhi, Hans P. A. Van Dongen, Debra J. Skene
Publikováno v:
Proc Natl Acad Sci U S A
Proceedings of the National Academy of Sciences of the United States of America
Proceedings of the National Academy of Sciences of the United States of America
Significance Shift workers, whose schedules are misaligned relative to their suprachiasmatic nuclei (SCN) circadian pacemaker, are at elevated risk of metabolic disorders. In a study of simulated day- versus night-shift work followed by a constant ro