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Autor:
Katherine O’Flaherty, Elizabeth A. Ashley, Rosanna Powell, Takafumi Tsuboi, Christine Langer, Michael J. Malloy, Julie A. Simpson, Mayfong Mayxay, Mehul Dhorda, Pharath Lim, Ricardo Ataíde, François Nosten, Rick M. Fairhurst, Sasithon Pukrittayakamee, Jo-Anne Chan, Chanaki Amaratunga, Eizo Takashima, M. Abul Faiz, Arjen M. Dondorp, Tran Tinh Hien, Nicholas P. J. Day, Ye Htut, Freya J. I. Fowkes, James G. Beeson, Nicholas J. White
Publikováno v:
Proceedings of the National Academy of Sciences. 114:3515-3520
Artemisinin-resistant falciparum malaria, defined by a slow-clearance phenotype and the presence of kelch13 mutants, has emerged in the Greater Mekong Subregion. Naturally acquired immunity to malaria clears parasites independent of antimalarial drug
Autor:
Concepción Palomo, Olga Cano, Mónica Herrero Vázquez, Vicente Mas, María C. Terrón, Margarita Magro, José A. Melero, Keith J. Chappell, Daniel Luque
Publikováno v:
Proceedings of the National Academy of Sciences. 109:3089-3094
Human respiratory syncytial virus (hRSV) is the most important viral agent of pediatric respiratory infections worldwide. The only specific treatment available today is a humanized monoclonal antibody (Palivizumab) directed against the F glycoprotein
Autor:
Georgia D. Tomaras, Carmen E. Gómez, Ulrike Wille-Reece, Munir Alam, Tibor Keler, Ralph M. Steinman, Ralf Wagner, Ross W. B. Lindsay, Kathrin Kastenmüller, Barbara J. Flynn, Beatriz Perdiguero, Chae Gyu Park, Christine Trumpfheller, Andres M. Salazar, Robert A. Seder, Mariano Esteban, Giuseppe Pantaleo
Publikováno v:
Proceedings of the National Academy of Sciences. 108:7131-7136
Protein vaccines, if rendered immunogenic, would facilitate vaccine development against HIV and other pathogens. We compared in nonhuman primates (NHPs) immune responses to HIV Gag p24 within 3G9 antibody to DEC205 (“DEC-HIV Gag p24”), an uptake
Publikováno v:
Proceedings of the National Academy of Sciences. 74:2135-2139
Inoculation of newborn mice with lymphocytic chloriomeningitis (LCM) virus resulted in decreased weight gain, liver cell necrosis, and death. Injection of potent sheep immunoglobulin against mouse interferon markedly inhibited these manifestations of