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Publikováno v:
Proc Natl Acad Sci U S A
Hepsin is a transmembrane serine protease primarily expressed in the liver. To date, the physiological function of hepsin remains poorly defined. Here we report that hepsin-deficient mice have low levels of blood glucose and lipids and liver glycogen
Autor:
Mohammad-Zaman Nouri, Tingting Wang, Zhentian Lei, Saurav J. Sarma, Barbara W. Sumner, R. Michael Roberts, Sixue Chen, Ashish Jain, Jiude Mao, Ning Zhu, Nathan J. Bivens, Cheryl S. Rosenfeld, Geetu Tuteja, Nancy D. Denslow, Lloyd W. Sumner, Jin Koh
Publikováno v:
Proc Natl Acad Sci U S A
Placental trophoblast cells are potentially at risk from circulating endocrine-disrupting chemicals, such as bisphenol A (BPA). To understand how BPA and the reputedly more inert bisphenol S (BPS) affect the placenta, C57BL6J mouse dams were fed 200
Autor:
Jay D. Horton
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Significance The intravascular processing of triglyceride-rich lipoproteins by the lipoprotein lipase (LPL)–GPIHBP1 complex is crucial for clearing triglycerides from the bloodstream and for the delivery of lipid nutrients to vital tissues. A defic
Publikováno v:
Proceedings of the National Academy of Sciences. 114:4811-4815
Malignant hyperthermia (MH) is a clinical syndrome of skeletal muscle that presents as a hypermetabolic response to volatile anesthetic gases, where susceptible persons may develop lethally high body temperatures. Genetic predisposition mainly arises
Autor:
Jie Zhang, Mengxing Chen, Rong Yan, Yang Zhang, Miao Jiang, Zhenyu Li, Jingluan Tian, Changgeng Ruan, Lili Zhao, Renping Hu, Qingya Cui, Yiwen Zhang, Sudan He, Kesheng Dai, Jian Zhang
Publikováno v:
Proceedings of the National Academy of Sciences. 114:2964-2969
Previous studies have shown that receptor-interacting protein kinase 3 (RIP3) is involved in many important biological processes, including necroptosis, apoptosis, and inflammation. Here we show that RIP3 plays a critical role in regulating platelet
Autor:
Ingrid Wernstedt Asterholm, John M. Shelton, Belén Chanclón, Anna Benrick, Yanling Wu, Peter Micallef, Laila Hadi, Elisabet Stener-Victorin
Publikováno v:
Proceedings of the National Academy of Sciences. 114
Adiponectin, together with adipocyte size, is the strongest factor associated with insulin resistance in women with polycystic ovary syndrome (PCOS). This study investigates the causal relationship between adiponectin levels and metabolic and reprodu
Autor:
Kenton M. Sanders, Bernard T. Drumm, Kent C. Sasse, Sean M. Ward, Masaaki Kurahashi, Sung Jin Hwang, Violeta N. Mutafova-Yambolieva, Leonie Durnin
Publikováno v:
Proceedings of the National Academy of Sciences. 111:15821-15826
Enteric purinergic motor neurotransmission, acting through P2Y1 receptors (P2Y1R), mediates inhibitory neural control of the intestines. Recent studies have shown that NAD(+) and ADP ribose better meet criteria for enteric inhibitory neurotransmitter
Autor:
Liane Renno, Gabriela Krasteva-Christ, Burkhard Schütz, Miriam Wolff, Amir Rafiq, Lars Wessels, Tamara Papadakis, Wolfgang Kummer, Katharina Filipski, Klaus Deckmann, Innokentij Jurastow, Vladimir Chubanov, Jochen Klein, Eberhard Weihe, Mike Althaus, Thomas Bschleipfer, Martin Fronius, Thomas Gudermann
Publikováno v:
Proceedings of the National Academy of Sciences. 111:8287-8292
Chemosensory cells in the mucosal surface of the respiratory tract ("brush cells") use the canonical taste transduction cascade to detect potentially hazardous content and trigger local protective and aversive respiratory reflexes on stimulation. So
Autor:
Solomon H. Snyder, Gary P.H. Ho, Hyo Jung Kim, Seyun Kim, Hyeonjin Choi, Jing Xu, Jae Woo Kim, Jiyoung Y. Cha, Feng Rao, Daham Kim, Bindu D. Paul, Jung Hwan Yu, Yoo Jeong Lee
Publikováno v:
Proceedings of the National Academy of Sciences. 110:20575-20580
Significance Glucocorticoids are well known to play a major role in obesity, but underlying mechanisms have been obscure. We demonstrate that the small G protein Dexras1, first identified based on its dramatic induction by glucocorticoids, mediates a
Publikováno v:
Proceedings of the National Academy of Sciences. 110:16987-16992
Aspirin-exacerbated respiratory disease (AERD) is characterized by asthma, tissue eosinophilia, overproduction of cysteinyl leukotrienes (cysLTs), and respiratory reactions to nonselective cyclooxygenase (COX) inhibitors. Ex vivo studies suggest that