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Publikováno v:
Proceedings of the National Academy of Sciences. 110:16987-16992
Aspirin-exacerbated respiratory disease (AERD) is characterized by asthma, tissue eosinophilia, overproduction of cysteinyl leukotrienes (cysLTs), and respiratory reactions to nonselective cyclooxygenase (COX) inhibitors. Ex vivo studies suggest that
Autor:
Charles R. Krois, Attilio Pingitore, Joo Yeon Ryu, Erika Cione, Joseph L. Napoli, Alexandra E. Folias, Mariarita Perri, Kristin M. Obrochta, Maureen A. Kane
Publikováno v:
Proceedings of the National Academy of Sciences. 107:21884-21889
The all-trans -retinoic acid (atRA) isomer, 9- cis -retinoic acid (9cRA), activates retinoic acid receptors (RARs) and retinoid X receptors (RXRs) in vitro. RARs control multiple genes, whereas RXRs serve as partners for RARs and other nuclear recept
Autor:
Bertha Dominguez, Brian K. Kaspar, Ronald W. Oppenheim, Yoshie Sugiura, Prafulla Aryal, Thomas W. Gould, Weichun Lin, Kuo-Fen Lee, Mark E. Hester, Mahru C. An, Chien-Ping Ko, Jiefei Yang, Daniel Padgett
Publikováno v:
Proceedings of the National Academy of Sciences. 107:10702-10707
Emerging evidence suggests that the neurotransmitter acetylcholine (ACh) negatively regulates the development of the neuromuscular junction, but it is not clear if ACh exerts its effects exclusively through muscle ACh receptors (AChRs). Here, we used
Autor:
Noa Noy, Daniel C. Berry, Le Cheng, Alexander Yu. Nikitin, Thaddeus T. Schug, Illia A. Toshkov
Publikováno v:
Proceedings of the National Academy of Sciences. 105:7546-7551
Retinoic acid (RA) displays potent anticarcinogenic activities that are mediated by the nuclear retinoic acid receptors (RARs). However, use of RA in oncology is limited by RA resistance acquired during carcinogenesis. Moreover, in some cancers, RA f
Autor:
Scott M. DeWire, Seungkirl Ahn, Jonathan D. Violin, Robert J. Lefkowitz, Sudha K. Shenoy, James W. Wisler, Erin J. Whalen, Matthew T. Drake
Publikováno v:
Proceedings of the National Academy of Sciences. 104:16657-16662
For many years, β-adrenergic receptor antagonists (β-blockers or βAR antagonists) have provided significant morbidity and mortality benefits in patients who have sustained acute myocardial infarction. More recently, β-adrenergic receptor antagoni
Autor:
Paul Robel, Etienne-Emile Baulieu, Sebastien David, Virginie Fontaine-Lenoir, Arlette Fellous, Yann Duchossoy, Béatrice Chambraud
Publikováno v:
Proceedings of the National Academy of Sciences. 103:4711-4716
The neurosteroid pregnenolone (PREG) and its chemically synthesized analog 3β-methoxypregnenolone (MePREG) bind to microtubule-associated protein 2 (MAP2) and stimulate the polymerization of microtubules. PREG, MePREG, and progesterone (PROG; the ph
Autor:
Seung Woo Kim, Ji Yeoun Yoo, Ko Woon Lee, Eric J. Nestler, Pyung Lim Han, Kang Woo Lee, Ja-Kyeong Lee, Joo Young Im, Kyoung Shim Kim
Publikováno v:
Proceedings of the National Academy of Sciences. 103:3908-3913
Opioid drugs produce their pharmacological effects by activating inhibitory guanine nucleotide-binding regulatory protein-linked μ, δ, and κ opioid receptors. One major effector for these receptors is adenylyl cyclase, which is inhibited upon rece
Autor:
Akinori Okumachi, Katsuhiko Ishizaki, Kohtaro Minami, Susumu Seino, Miho Kawaguchi, Toshihiko Iwanaga, Masaaki Okuno, Nobuko Ishizuka, Kazumasa Miyawaki, Kazunobu Oyama
Publikováno v:
Proceedings of the National Academy of Sciences. 102:15116-15121
Although several studies have suggested that insulin-secreting cells can be generated in vitro from cells residing in adult exocrine pancreas, neither the origin of these cells nor their precise insulin secretory properties was obtained. We show here
Publikováno v:
Proceedings of the National Academy of Sciences. 102:9044-9049
A crucial biochemical reaction in vertebrates is progesterone conversion into neuroactive metabolites such as dihydroprogesterone (5α-DHP) and tetrahydroprogesterone (3α,5α-THP), which regulate several neurobiological processes, including stress,
Autor:
Masaki Nakane, Jorge D. Brioni, Petter Hedlund, Mark A. Osinski, Karl-Erik Andersson, Robert B. Moreland, Marlon D. Cowart, Teodozyi Kolasa, Andrew O. Stewart, James S. Polakowski, Diana L. Donnelly-Roberts, James J. Lynch, Kennan C. Marsh, Gin C. Hsieh, James P. Sullivan
Publikováno v:
Proceedings of the National Academy of Sciences. 101:6758-6763
Apomorphine, a nonselective dopamine receptor agonist, facilitates penile erection and is effective in patients suffering from erectile dysfunction. The specific dopamine receptor subtype(s) responsible for its erectogenic effect is not known. Here w