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Autor:
Zhaoting Li, Yuexin Shen, Minjie Sun, Dandan Hu, Wenhao Wu, Lianghan Zhu, Yixin Wang, Chenggen Qian, Honghao Sun
Publikováno v:
Proc Natl Acad Sci U S A
Clinical investigations have shown that a nonimmunogenic "cold" tumor is usually accompanied by few immunopositive cells and more immunosuppressive cells in the tumor microenvironment (TME), which is still the bottleneck of immune activation. Here, a
Autor:
Alex J. B. Kreutzberger, Eylan Yutuc, Haiyan Zhao, Abhinav Diwan, Michael D. Vahey, Maria Florencia Gomez Castro, Hu Zhang, Paul W. Rothlauf, Ruochen Zang, Sheng Shen, Siyuan Ding, Sayantan Bose, Yuqin Wang, Daved H. Fremont, Kartik Mani, Gaopeng Hou, Haitao Guo, Xin Wang, Sean P. J. Whelan, James Brett Case, Xiucui Ma, Tom Kirchhausen, Michael S. Diamond, William J. Griffiths, Qiru Zeng, Juhee Son, Zhuoming Liu
Publikováno v:
Proceedings of the National Academy of Sciences
Proceedings of the National Academy of Sciences of the United States of America
Proceedings of the National Academy of Sciences of the United States of America
Significance The novel severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), the etiological agent of coronavirus disease-2019 (COVID-19), has swept the world in unprecedented speed. In a few months, SARS-CoV-2 has infected millions of people
Autor:
Rolf Müller, Robert Landick, Mirjana Lilic, Jennifer Herrmann, Rachel A. Mooney, Hande Boyaci, Elizabeth A. Campbell, Nathaniel Braffman, James Chen, Seth A. Darst, Elizabeth A. Hubin
Publikováno v:
Proceedings of the National Academy of Sciences. 117:30423-30432
Rifampicin (Rif) is a first-line therapeutic used to treat the infectious disease tuberculosis (TB), which is caused by the pathogen Mycobacterium tuberculosis (Mtb). The emergence of Rif-resistant (RifR) Mtb presents a need for new antibiotics. Rif
Publikováno v:
Proc Natl Acad Sci U S A
The structure of lincomycin A consists of the unusual eight-carbon thiosugar core methyllincosamide (MTL) decorated with a pendent N-methylprolinyl moiety. Previous studies on MTL biosynthesis have suggested GDP-ᴅ-erythro-α-ᴅ-gluco-octose and GD
Autor:
Zhongying Yang, Bruce L. Patton, Min Woo Sung, Camden M. Driggers, Daniel M. Zuckerman, John D. Russo, Show-Ling Shyng, Barmak Mostofian
Publikováno v:
Proceedings of the National Academy of Sciences. 118
Vascular tone is dependent on smooth muscle KATP channels comprising pore-forming Kir6.1 and regulatory SUR2B subunits, in which mutations cause Cantu syndrome. Unique among KATP isoforms, they lack spontaneous activity and require Mg-nucleotides for
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Behnam and Klein (1) carried out in vitro assays on two severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) main protease (Mpro) inhibitors, including atazanavir reported by us (2), using an Mpro protein with C-terminal His-tag under various
Publikováno v:
Proc Natl Acad Sci U S A
Significance Fosfomycin is an antibiotic used for the treatment of cystitis. Its activity against both gram-positive and gram-negative pathogens has received strong recent interest. The compound is biosynthesized by both pseudomonads and streptomycet
Autor:
Jyoti Madhusoodanan
Publikováno v:
Proceedings of the National Academy of Sciences. 117:9135-9137
Millions of patients with Parkinson’s disease rely on the drug Levodopa for relief from tremors, slowed movement, and other motor symptoms. But many patients experience side effects such as cardiac arrhythmias, nausea, and gastrointestinal problems
Autor:
Elizabeth S. Sattely, Ramesha B. Thimmappa, Anne Osbourn, Hannah E. Hodgson, Jason Leigh Vincent, Michael J. Stephenson, Ricardo De La Peña
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Significance Limonoids are natural products made by members of the Meliaceae and Rutaceae families. Some limonoids (e.g., azadirachtin) are toxic to insects yet harmless to mammals. The use of limonoids in crop protection and other applications curre
Autor:
Ashley Lee, Tim Pasch, Charlotte Franck, Shaun P. Jackson, Emma E. Watson, Jessica Sayers, Bhavesh Premdjee, Pedro M. Martins, Pedro Pereira, Jorge Ripoll-Rozada, Richard J. Payne, Mike C. L. Wu, Maria Filipa Pinto
Publikováno v:
Proceedings of the National Academy of Sciences. 116:13873-13878
Hematophagous organisms produce a suite of salivary proteins which interact with the host's coagulation machinery to facilitate the acquisition and digestion of a bloodmeal. Many of these biomolecules inhibit the central blood-clotting serine protein