Zobrazeno 1 - 10
of 215
pro vyhledávání: ''
Autor:
Rolf Müller, Robert Landick, Mirjana Lilic, Jennifer Herrmann, Rachel A. Mooney, Hande Boyaci, Elizabeth A. Campbell, Nathaniel Braffman, James Chen, Seth A. Darst, Elizabeth A. Hubin
Publikováno v:
Proceedings of the National Academy of Sciences. 117:30423-30432
Rifampicin (Rif) is a first-line therapeutic used to treat the infectious disease tuberculosis (TB), which is caused by the pathogen Mycobacterium tuberculosis (Mtb). The emergence of Rif-resistant (RifR) Mtb presents a need for new antibiotics. Rif
Publikováno v:
Proc Natl Acad Sci U S A
The structure of lincomycin A consists of the unusual eight-carbon thiosugar core methyllincosamide (MTL) decorated with a pendent N-methylprolinyl moiety. Previous studies on MTL biosynthesis have suggested GDP-ᴅ-erythro-α-ᴅ-gluco-octose and GD
Autor:
Elizabeth S. Sattely, Ramesha B. Thimmappa, Anne Osbourn, Hannah E. Hodgson, Jason Leigh Vincent, Michael J. Stephenson, Ricardo De La Peña
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Significance Limonoids are natural products made by members of the Meliaceae and Rutaceae families. Some limonoids (e.g., azadirachtin) are toxic to insects yet harmless to mammals. The use of limonoids in crop protection and other applications curre
Publikováno v:
Proc Natl Acad Sci U S A
Significance Fosfomycin is an antibiotic used for the treatment of cystitis. Its activity against both gram-positive and gram-negative pathogens has received strong recent interest. The compound is biosynthesized by both pseudomonads and streptomycet
Autor:
Jyoti Madhusoodanan
Publikováno v:
Proceedings of the National Academy of Sciences. 117:9135-9137
Millions of patients with Parkinson’s disease rely on the drug Levodopa for relief from tremors, slowed movement, and other motor symptoms. But many patients experience side effects such as cardiac arrhythmias, nausea, and gastrointestinal problems
Autor:
Isabell Hügli, Natalie Schützler, Jean-Yves Roignant, Stefanie Ryglewski, Giriram K. Mohana, Carsten Duch, Chantal Girwert
Publikováno v:
Proceedings of the National Academy of Sciences. 116:3805-3810
Adrenergic signaling profoundly modulates animal behavior. For example, the invertebrate counterpart of norepinephrine, octopamine, and its biological precursor and functional antagonist, tyramine, adjust motor behavior to different nutritional state
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Significance The RNA world hypothesis assumes the abiotic synthesis of nucleotides, as well as their participation in nonenzymatic RNA replication. Whereas prebiotic syntheses of the canonical purine nucleotides remain inefficient, a prebiotically pl
Autor:
Sesha Manuguri, Mingdi Yan, Olof Ramström, Bin Wu, Giampiero Proietti, Sheng Xie, Yang Zhang, A. Ken Inge, Daniel Hall, Ying Fu, Joakim Romson
Publikováno v:
Proceedings of the National Academy of Sciences. 114:8464-8469
We report the modular formulation of ciprofloxacin-based pure theranostic nanodrugs that display enhanced antibacterial activities, as well as aggregation-induced emission (AIE) enhancement that was successfully used to image bacteria. The drug deriv
Publikováno v:
Goesten, M G, Hoffmann, R, Bickelhaupt, F M & Hensen, E J M 2017, ' Eight-coordinate fluoride in a silicate double-four-ring ', Proceedings of the National Academy of Sciences of the United States of America, vol. 114, no. 5, pp. 828-833 . https://doi.org/10.1073/pnas.1615742114
Proceedings of the National Academy of Sciences of the United States of America (PNAS), 114(5). National Academy of Sciences
Proceedings of the National Academy of Sciences USA, 114, 5, pp. 828-833
Proceedings of the National Academy of Sciences USA, 114, 828-833
Proceedings of the National Academy of Sciences of the United States of America, 114(5), 828-833. National Acad Sciences
Proceedings of the National Academy of Sciences of the United States of America (PNAS), 114(5). National Academy of Sciences
Proceedings of the National Academy of Sciences USA, 114, 5, pp. 828-833
Proceedings of the National Academy of Sciences USA, 114, 828-833
Proceedings of the National Academy of Sciences of the United States of America, 114(5), 828-833. National Acad Sciences
Significance Although strain and bonding are often antagonists in chemistry, they may also work together. When fluoride enters a silicate double-four-ring (D4R), their conjoined effect leads to fluoride binding to 8 silicon atoms. The strain comes fr
Autor:
David Leys, Marcus Hans, Aad Vollebregt, Andrew W. Munro, Jan Metske Van Der Laan, Ben Meijrink, Kang Lan Tee, Wibo B. van Scheppingen, Marco A. van den Berg, Kirsty J. McLean
Publikováno v:
Proceedings of the National Academy of Sciences. 112:2847-2852
The cholesterol-lowering blockbuster drug pravastatin can be produced by stereoselective hydroxylation of the natural product compactin. We report here the metabolic reprogramming of the antibiotics producer Penicillium chrysogenum toward an industri