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Autor:
Akinori Okumachi, Katsuhiko Ishizaki, Kohtaro Minami, Susumu Seino, Miho Kawaguchi, Toshihiko Iwanaga, Masaaki Okuno, Nobuko Ishizuka, Kazumasa Miyawaki, Kazunobu Oyama
Publikováno v:
Proceedings of the National Academy of Sciences. 102:15116-15121
Although several studies have suggested that insulin-secreting cells can be generated in vitro from cells residing in adult exocrine pancreas, neither the origin of these cells nor their precise insulin secretory properties was obtained. We show here
Publikováno v:
Proceedings of the National Academy of Sciences. 94:2724-2728
Previous studies have shown that chronic administration of class I antiarrhythmic drugs, which have definite inhibitory action on the fast Na + channel, result in up-regulation of cardiac Na + channel expression, and suggest that this effect may cont
Autor:
Susan E. Leeman, Robert E. Carraway, Ignazio Castagliuolo, Charalabos Pothoulakis, Erzsébet Bartolák-Suki, Bosheng Qiu, S Nikulasson
Publikováno v:
Proceedings of the National Academy of Sciences. 93:12611-12615
We previously reported that short-term immobilization stress of rats causes increased colonic mucin release, goblet cell depletion, prostaglandin E2 secretion, and colonic mast cell activation, as well as increased colonic motility. The purpose of th
Autor:
Maggie M.-Y. Chi, Beverly J. Norris, David B. McDougal, Vera Yip, Joyce G. Carter, Jill K. Manchester, James A. Ferrendelli, Mary Ellen Pusateri, Oliver H. Lowry
Publikováno v:
Proceedings of the National Academy of Sciences. 87:1357-1361
A method is presented for measuring rapid changes in the rate of glucose phosphorylation in mouse brain with nonradioactive 2-deoxyglucose (DG). After times as short as 1 min after DG injection, the mouse is frozen rapidly, and selected brain regions
Publikováno v:
Proceedings of the National Academy of Sciences. 72:4385-4388
The enhancement of long-chain fatty acid oxidation and ketogenesis in the perfused rat liver, whether induced acutely by treatment of fed animals with anti-insulin serum or glucagon, or over the longer term by starvation or the induction of alloxan d
Autor:
Isidore S. Edelman, Nurit Kaiser
Publikováno v:
Proceedings of the National Academy of Sciences. 74:638-642
A potent glucocorticoid, triamcinolone acetonide (9alpha-fluoro-11beta, 16alpha,17alpha, 21-tetrahydroxypregna-1,4-diene-3,20-dione-16,17-acetonide) and a divalent cation ionophore (A23187) had similar effects in vitro on [3H]uridine uptake and on ly
Autor:
Shigetoshi Sayama, Jiro Imanishi, Osamu Hayaishi, Tsunataro Kishida, Tohru Oku, Ryotaro Yoshida
Publikováno v:
Proceedings of the National Academy of Sciences. 78:7327-7330
Inhibitors of fatty acid cyclooxygenase such as indomethacin (0.1 mM), phenylbutazone (0.3 mM), and aspirin (1 mM) were found to suppress almost completely the interferon-mediated induction of indoleamine 2,3-dioxygenase in mouse lung slices. However
Autor:
Martha M. Bosma, Bertil Hille
Publikováno v:
Proceedings of the National Academy of Sciences. 86:2943-2947
Frog sympathetic ganglion cells were studied under whole-cell voltage clamp to determine whether protein kinase C (PKC) mediates peptide-induced suppression of M current (IM) or desensitization of peptide receptors. Low concentrations (10 mM) of chic
Autor:
Thian C. Ng, Michael B. Lilly, Jerry D. Glickson, A.J. Lawson, John R. Durant, W. T. Evanochko, Thomas H. Corbett
Publikováno v:
Proceedings of the National Academy of Sciences. 80:334-338
31 P NMR spectroscopy with surface coils has been used to monitor, in vivo , the phosphate metabolism of subcutaneously implanted mammary 16/C adenocarcinoma in C3H/He mice. This model tumor was studied during untreated tumor growth and after treatme
Publikováno v:
Proceedings of the National Academy of Sciences. 77:4364-4368
Adrenal medullary chromaffin cells maintained in a chemically defined, serum-free medium retain high levels of both catecholamines and opiate-like peptides. At least 25% of the opioid activity as measured by radioreceptor assay is present as [Met]- a