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Autor:
Gloria S. Huang, Roberto Angioli, Titus J. Boggon, Weilai Dong, Ludmil B. Alexandrov, Gulden Menderes, Elena Bonazzoli, Francesco Raspagliesi, Richard P. Lifton, Chanhee Han, Aranzazu Manzano, Franco Odicino, Peter E. Schwartz, Antonella Ravaggi, Kaya Bilguvar, Emanuele Perrone, Laura Zanotti, Elena Ratner, Salvatore Lopez, Laura Ardighieri, Joseph Schlessinger, Valentina Pirazzoli, Jungmin Choi, Gary Altwerger, Francesca Pettinella, Siming Zhao, Alessandro D. Santin, Masoud Azodi, Carla Donzelli, Luca Zammataro, Natalia Buza, Paola Todeschini, Burak Zeybek, Dan-Arin Silasi, Eliana Bignotti, Stefania Bellone, Sergio Pecorelli, Pei Hui, Chiara Romani, Serena Wong, Amy L. Stiegler, Emiliano Cocco, Paola Manara, Giovanni Scambia, Anna Bianchi
Publikováno v:
Proceedings of the National Academy of Sciences. 116:22730-22736
The prognosis of advanced/recurrent cervical cancer patients remains poor. We analyzed 54 fresh-frozen and 15 primary cervical cancer cell lines, along with matched-normal DNA, by whole-exome sequencing (WES), most of which harboring Human-Papillomav
Autor:
Joseph L. Goldstein, Qiren Liang, Jef K. De Brabander, Xiaochun Li, Akash Das, Feiran Lu, Michael S. Brown, Michael N. Trinh
Publikováno v:
Proceedings of the National Academy of Sciences. 114:89-94
Niemann–Pick C1 (NPC1), a membrane protein of lysosomes, is required for the export of cholesterol derived from receptor-mediated endocytosis of LDL. Lysosomal cholesterol export is reportedly inhibited by itraconazole, a triazole that is used as a
Publikováno v:
Proceedings of the National Academy of Sciences. 113:11507-11512
Cisplatin is a major anticancer drug that kills cancer cells by damaging their DNA. Cancer cells cope with the drug by removal of the damages with nucleotide excision repair. We have developed methods to measure cisplatin adduct formation and its rep
Autor:
Do Youn Park, Hyung Il Seo, Seung Kew Yoon, Su-Hyung Park, George R. Stark, Chung Hwan Cho, Pil Soo Sung, Eui-Cheol Shin, HyeonJoo Cheon, Seon Hui Hong
Publikováno v:
Proceedings of the National Academy of Sciences. 112:10443-10448
Up-regulation of IFN-stimulated genes (ISGs) is sustained in hepatitis C virus (HCV)-infected livers. Here, we investigated the mechanism of prolonged ISG expression and its role in IFN responsiveness during HCV infection in relation to unphosphoryla
Autor:
Shailaja Kesaraju, Howard Prentice, Danhong Zhu, Janet C. Blanks, Diane Baronas-Lowell, Arunodoy Sur, Kasirajan Ayyanathan, David R. Hinton, Herbert Weissbach
Publikováno v:
Proceedings of the National Academy of Sciences. 111:16754-16759
The retinal pigmented epithelial (RPE) layer is one of the major ocular tissues affected by oxidative stress and is known to play an important role in the etiology of age-related macular degeneration (AMD), the major cause of blinding in the elderly.
Publikováno v:
Proceedings of the National Academy of Sciences
Proceedings of the National Academy of Sciences of the United States of America, 110 (45)
Proceedings of the National Academy of Sciences of the United States of America, 110 (45)
Synthetic biology has significantly advanced the design of synthetic trigger-controlled devices that can reprogram mammalian cells to interface with complex metabolic activities. In the brain, the neurotransmitter dopamine coordinates communication w
Autor:
Luzviminda Feeney, David Dankort, Tiffany K. Dong, Wade Wilson, Stephanie Bruguera, Dennis H. Oh, Ingrid Revet, James E. Cleaver
Publikováno v:
Proceedings of the National Academy of Sciences. 108:8663-8667
The phosphorylation of H2Ax on its S139 site, γH2Ax, is important during DNA double-strand repair and is considered necessary for assembly of repair complexes, but its functional role after other kinds of DNA damage is less clear. We have measured t
Autor:
Charles R. Krois, Attilio Pingitore, Joo Yeon Ryu, Erika Cione, Joseph L. Napoli, Alexandra E. Folias, Mariarita Perri, Kristin M. Obrochta, Maureen A. Kane
Publikováno v:
Proceedings of the National Academy of Sciences. 107:21884-21889
The all-trans -retinoic acid (atRA) isomer, 9- cis -retinoic acid (9cRA), activates retinoic acid receptors (RARs) and retinoid X receptors (RXRs) in vitro. RARs control multiple genes, whereas RXRs serve as partners for RARs and other nuclear recept
Autor:
Shizuo Akira, Yukana Nakaima, David Savitsky, ZhiChao Wang, Yan Lu, Tadatsugu Taniguchi, Hideyuki Yanai, Tatsuma Ban, Sho Hangai, Makoto Nakasato, Kenya Honda, Myoung Kwon Choi, Tomohiko Tamura, Osamu Takeuchi, Ryuji Koshiba, Hideo Negishi
Publikováno v:
Proceedings of the National Academy of Sciences. 106:17870-17875
The activation of the innate immune responses by DNA exposed within the cytosol has gained much attention and, in this context, several cytosolic DNA sensors have been identified. However, previous studies revealed the operation of redundant and comp
Autor:
Ajay Ravindranathan, Margaret Robertson, Raymond L. White, Marc A. Schuckit, Jennifer L. Whistler, Geoff Joslyn
Publikováno v:
Proceedings of the National Academy of Sciences. 106:10811-10816
Opioids and their receptors have an important role in analgesia and alcohol and substance use disorders (ASUD). We have identified several naturally occurring amino acid changing variants of the human mu-opioid receptor (MOR), and assessed the functi