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Publikováno v:
Proceedings of the National Academy of Sciences. 92:4477-4481
We assembled a DNA clone containing the 11,161-nt sequence of the prototype rhabdovirus, vesicular stomatitis virus (VSV), such that it could be transcribed by the bacteriophage T7 RNA polymerase to yield a full-length positive-strand RNA complementa
Publikováno v:
Proceedings of the National Academy of Sciences. 92:2076-2080
The anticancer drug cis-diamminedichloro-platinum(II) (cisplatin) covalently modifies DNA, and these lesions are thought to lead to cell death by inhibiting DNA and RNA synthesis. By using in vivo analysis techniques, we have investigated the influen
Publikováno v:
Proceedings of the National Academy of Sciences. 91:11333-11337
Antiprogestins inhibit progesterone action by competing for binding to the progesterone receptor and are potentially important pharmaceuticals in fertility control and cancer therapy. Why the complex of antiprogestins and progesterone receptor is fun
Autor:
Benjamin Gaston, Koichiro Asano, Jonathan S. Stamler, Cynthia B. E. Chee, Jeffrey M. Drazen, Craig M. Lilly, Craig Gerard
Publikováno v:
Proceedings of the National Academy of Sciences. 91:10089-10093
Histochemical activity and immunoreactivity of nitric oxide synthase (NOS, EC 1.14.13.39) have been recently demonstrated in human lung epithelium. However, the molecular nature of NOS and the regulation and function of the enzyme(s) in the airway is
Publikováno v:
Proceedings of the National Academy of Sciences. 91:10232-10236
The human receptor Fc gamma RIIA for the Fc portion of IgG (Fc gamma) was expressed in a human T-cell line and conferred on these cells the ability to perform IgG antibody-stimulated phagocytosis. Crosslinking Fc gamma RIIA with anti-Fc gamma RII mon
Publikováno v:
Proceedings of the National Academy of Sciences. 91:7903-7906
Treatment of Chinese hamster lung fibroblasts (CCl 39 cells) with the impermeable iron(II) chelator bathophenanthroline disulfonate (BPS) inhibits DNA synthesis when cell growth is initiated with growth factors including epidermal growth factor plus
Publikováno v:
Proceedings of the National Academy of Sciences. 91:649-653
Molecular cloning studies have defined a family of dopamine D2-like receptors (D2, D3, and D4), which are the products of separate genes. Our previous work has shown that stimulation of dopamine D2-like receptors in cultures of fetal cortical neurons
Publikováno v:
Proceedings of the National Academy of Sciences. 91:609-613
AP-1 transcriptional activity is stimulated by the transformation promoters phorbol 12-myristate 13-acetate ("12-O-tetradecanoylphorbol 13-acetate," TPA) and epidermal growth factor (EGF) in promotion-sensitive (P+) but not in promotion-resistant (P-
Publikováno v:
Proceedings of the National Academy of Sciences. 90:10086-10090
To identify the metabolic pathway that generates choline (Cho) for acetylcholine (AcCho) from its storage pool in membrane phosphatidylcholine (PtdCho), human neuronal cells (LA-N-2) were radioisotopically labeled with 1-O-hexadecyl-2-hydroxy-sn-glyc
Publikováno v:
Proceedings of the National Academy of Sciences. 90:10260-10264
The POU family of proteins binds specifically to octamer DNA motifs present in the promoters of several genes and regulates their expression. We identified the presence of four members of the POU family of proteins, Oct-1, Oct-2, Oct-T1, and Oct-T2,