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Autor:
J. Alejandro D’Aquino, Aziz Sancar, Shuzhong Zhang, Stephen J. Lippard, Kathleen M. Giacomini, Joyce T. Reardon, Katherine S. Lovejoy, Michael S. McCormick, Ryan C. Todd
Publikováno v:
Proceedings of the National Academy of Sciences. 105:8902-8907
We have identified unique chemical and biological properties of a cationic monofunctional platinum(II) complex, cis -diammine(pyridine)chloroplatinum(II), cis -[Pt(NH 3 ) 2 (py)Cl] + or cDPCP, a coordination compound previously identified to have sig
Publikováno v:
Proceedings of the National Academy of Sciences. 101:18141-18146
Overproduction of nitric oxide (NO) by inducible nitric oxide synthase (iNOS) has been implicated in the pathogenesis of many disorders. iNOS is notably distinguished from constitutive NOSs by its production of large amounts of NO for a prolonged per
Autor:
Nevenka Matijevic-Aleksic, Min Du, Xian Ming Chen, Kenneth K. Wu, Xiao Ming Xu, Leticia Sansores-Garcia
Publikováno v:
Proceedings of the National Academy of Sciences. 96:5292-5297
The pharmacological action of salicylate cannot be explained by its inhibition of cyclooxygenase (COX) activity. In this report, the effects of aspirin and sodium salicylate on COX-2 expressions in human umbilical vein endothelial cells and foreskin
Publikováno v:
Proceedings of the National Academy of Sciences. 92:2076-2080
The anticancer drug cis-diamminedichloro-platinum(II) (cisplatin) covalently modifies DNA, and these lesions are thought to lead to cell death by inhibiting DNA and RNA synthesis. By using in vivo analysis techniques, we have investigated the influen
Publikováno v:
Proceedings of the National Academy of Sciences. 91:11333-11337
Antiprogestins inhibit progesterone action by competing for binding to the progesterone receptor and are potentially important pharmaceuticals in fertility control and cancer therapy. Why the complex of antiprogestins and progesterone receptor is fun
Publikováno v:
Proceedings of the National Academy of Sciences. 90:10260-10264
The POU family of proteins binds specifically to octamer DNA motifs present in the promoters of several genes and regulates their expression. We identified the presence of four members of the POU family of proteins, Oct-1, Oct-2, Oct-T1, and Oct-T2,
Publikováno v:
Proceedings of the National Academy of Sciences. 87:4884-4888
We show that the stimulation of human immunodeficiency virus (HIV) brought about by tumor necrosis factor alpha and phorbol 12-myristate 13-acetate can be inhibited by adding N-acetyl-L-cysteine (NAC). NAC, which replenishes intracellular glutathione
Autor:
Luiz F. L. Reis, Tadatsugu Taniguchi, Nobumasa Watanabe, Jan Vilcek, Yoko Kimura, Takashi Fujita
Publikováno v:
Proceedings of the National Academy of Sciences. 86:9936-9940
Nuclear protein IRF-1 (interferon regulatory factor 1) was earlier shown to bind to cis-acting regulatory elements present on interferon (IFN)-alpha/beta genes and some IFN-inducible genes. Here we show that in both human FS-4 and murine L929 cells,
Autor:
Edward A. Havell, Jan Vilcek
Publikováno v:
Proceedings of the National Academy of Sciences. 70:3909-3913
Interferon production was induced in a strain of human diploid foreskin cells with poly(I).poly(C). Cycloheximide was included in the culture medium at the time of addition of the inducer. Actinomycin D was added to the cultures 4 or 5 hr later, befo
Autor:
J. G. Szelenyi, Margit Horányi, E. Olah, J Sugar, Z Kote, Y. Natsumeda, E Paulik, T. Kremmer, T Ikegami, Susan R. Hollán
Publikováno v:
Proceedings of the National Academy of Sciences. 85:6533-6537
Tiazofurin (2-beta-D-ribofuranosyl-4-thiazole-carboxamide; NSC 286193), an antitumor carbon-linked nucleoside that inhibits IMP dehydrogenase (IMP:NAD+ oxidoreductase; EC 1.1.1.205) and depletes guanylate levels, can activate the erythroid differenti