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Autor:
Shailaja Kesaraju, Howard Prentice, Danhong Zhu, Janet C. Blanks, Diane Baronas-Lowell, Arunodoy Sur, Kasirajan Ayyanathan, David R. Hinton, Herbert Weissbach
Publikováno v:
Proceedings of the National Academy of Sciences. 111:16754-16759
The retinal pigmented epithelial (RPE) layer is one of the major ocular tissues affected by oxidative stress and is known to play an important role in the etiology of age-related macular degeneration (AMD), the major cause of blinding in the elderly.
Autor:
Claudia Mugler, Christian Peschel, Oliver G. Ottmann, Jochen B. Geigl, Rebekka Grundler, Justus Duyster, Cornelius Miething, Michael R. Speicher, J Hoepfl, Simone Brero
Publikováno v:
Proceedings of the National Academy of Sciences. 104:4594-4599
The kinase inhibitor imatinib mesylate targeting the oncoprotein Bcr-Abl has revolutionized the treatment of chronic myeloid leukemia (CML). However, even though imatinib successfully controls the leukemia in chronic phase, it seems not to be able to
Autor:
Paula C. Fernandez, Volker Heussler, Joel Machado, Guy H. Palmer, Dirk A. E. Dobbelaere, Therese Perinat
Publikováno v:
Proceedings of the National Academy of Sciences. 94:12527-12532
Infection of cattle with the protozoanTheileria parvaresults in uncontrolled T lymphocyte proliferation resulting in lesions resembling multicentric lymphoma. Parasitized cells exhibit autocrine growth characterized by persistent translocation of the
Autor:
Joseph M. Colacino, Eric S. Levine, Kyoichi A. Watanabe, Brone Griniuviene, Jean-Pierre Sommadossi, Fred W. Perrino, William Lewis, Kevin O. Tankersley
Publikováno v:
Proceedings of the National Academy of Sciences. 93:3592-3597
The thymidine analog fialuridine deoxy-2-fluoro-beta-D-arabinofuranosyl)-5-iodouracil (FIAU) was toxic in trials for chronic hepatitis B infection. One mechanism postulated that defective mtDNA replication was mediated through inhibition of DNA polym
Publikováno v:
Proceedings of the National Academy of Sciences. 93:1238-1242
P-glycoprotein (Pgp), a transmembrane efflux pump encoded by the MDR1 gene, transports various lipophilic drugs that enter the cell by passive diffusion through the lipid bilayer. Pgp-expressing multidrug-resistant cell lines are not usually cross-re
Autor:
Benjamin Gaston, Koichiro Asano, Jonathan S. Stamler, Cynthia B. E. Chee, Jeffrey M. Drazen, Craig M. Lilly, Craig Gerard
Publikováno v:
Proceedings of the National Academy of Sciences. 91:10089-10093
Histochemical activity and immunoreactivity of nitric oxide synthase (NOS, EC 1.14.13.39) have been recently demonstrated in human lung epithelium. However, the molecular nature of NOS and the regulation and function of the enzyme(s) in the airway is
Publikováno v:
Proceedings of the National Academy of Sciences. 91:10232-10236
The human receptor Fc gamma RIIA for the Fc portion of IgG (Fc gamma) was expressed in a human T-cell line and conferred on these cells the ability to perform IgG antibody-stimulated phagocytosis. Crosslinking Fc gamma RIIA with anti-Fc gamma RII mon
Publikováno v:
Proceedings of the National Academy of Sciences. 87:4981-4985
Optimal expression of the high-affinity Fc receptor for IgG (FcRI) by the human monocyte cell line U-937 requires the presence of low density lipoprotein (LDL), and neither cholesterol nor high density lipoprotein can provide the component necessary
Autor:
Stanley B. Prusiner, C. Warren Olanow
Publikováno v:
Proceedings of the National Academy of Sciences. 106:12571-12572
Neuronal accumulation of alpha-synuclein and Lewy body formation are characteristic to many neurodegenerative diseases, including Parkinson's disease (PD). This Lewy pathology appears to spread throughout the brain as the disease progresses. Furtherm
Autor:
P A Maher
Publikováno v:
Proceedings of the National Academy of Sciences. 85:6788-6791
When the sympathetic nerve-like cell line PC12 is exposed to nerve growth factor (NGF), there is a rapid and transient phosphorylation of tyrosine residues in cellular proteins, as demonstrated by immunoblotting of cell extracts with high-affinity po