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Publikováno v:
Proceedings of the National Academy of Sciences. 112:3547-3552
TMEM16A (transmembrane protein 16) (Anoctamin-1) forms a calcium-activated chloride channel (CaCC) that regulates a broad array of physiological properties in response to changes in intracellular calcium concentration. Although known to conduct anion
Publikováno v:
Proceedings of the National Academy of Sciences. 111:3176-3181
Acetaminophen (paracetamol) is the most frequently used analgesic and antipyretic drug available over the counter. At the same time, acetaminophen overdose is the most common cause of acute liver failure and the leading cause of chronic liver damage
Autor:
Joachim W. Deitmer, Daniela Hirnet, Christian Lohr, Michael Doengi, Hans-Christian Pape, Philippe Coulon
Publikováno v:
Proceedings of the National Academy of Sciences. 106:17570-17575
We studied GABAergic signaling in astrocytes of olfactory bulb slices using confocal Ca 2+ imaging and two-photon Na + imaging. GABA evoked Ca 2+ transients in astrocytes that persisted in the presence of GABA A and GABA B receptor antagonists, but w
Autor:
Oleg Vsevolodovich Gerasimenko, Katsuhiko Mikoshiba, Ole H. Petersen, Etsuko Ebisui, Julia Vladimirovna Gerasimenko, Alexei V. Tepikin, Mark W. Sherwood, Gyorgy Lur
Publikováno v:
Proceedings of the National Academy of Sciences. 106:10758-10763
Toxic alcohol effects on pancreatic acinar cells, causing the often fatal human disease acute pancreatitis, are principally mediated by fatty acid ethyl esters (non-oxidative products of alcohol and fatty acids), emptying internal stores of Ca 2+ . T
Autor:
Vasiliki Zoga, Quinn H. Hogan, Wai-Meng Kwok, Takashi Kawano, Hsiang En Wu, Geza Gemes, Constantine Sarantopoulos, J. Bruce McCallum, Mei Ying Liang, Danijel Pravdic
Publikováno v:
Proceedings of the National Academy of Sciences. 106:8725-8730
Painful axotomy decreases K ATP channel current (IK ATP ) in primary afferent neurons. Because cytosolic Ca 2+ signaling is depressed in injured dorsal root ganglia (DRG) neurons, we investigated whether Ca 2+ –calmodulin (CaM)–Ca 2+ /CaM-depende
Autor:
Lindsay S. Wilson, Donald H. Maurice, Hisham S. Elbatarny, Brian M. Bennett, Scott W. Crawley
Publikováno v:
Proceedings of the National Academy of Sciences. 105:13650-13655
It is generally accepted that nitric oxide (NO) donors, such as sodium nitroprusside (SNP), or phosphodiesterase 5 (PDE5) inhibitors, including sildenafil, each impact human platelet function. Although a strong correlation exists between the actions
Autor:
Miklós Sahin-Tóth, Richárd Szmola
Publikováno v:
Proceedings of the National Academy of Sciences. 104:11227-11232
Digestive trypsins undergo proteolytic breakdown during their transit in the human alimentary tract, which has been assumed to occur through trypsin-mediated cleavages, termed autolysis. Autolysis was also postulated to play a protective role against
Autor:
Robert A. Johnson, T. Bruce Ferguson, Sampath Parthasarathy, Mahesh S. Joshi, Jack R. Lancaster, Fruzsina K Johnson
Publikováno v:
Proceedings of the National Academy of Sciences. 104:9982-9987
Arginine contains the guanidinium group and thus has structural similarity to ligands of imidazoline and α-2 adrenoceptors (α-2 AR). Therefore, we investigated the possibility that exogenous arginine may act as a ligand for these receptors in human
Autor:
Satoshi Kurihara, Kimiaki Komukai, Hiroyuki Sasaki, Yoichiro Kusakari, Jin O-Uchi, Kenichi Hongo, Toru Obata
Publikováno v:
Proceedings of the National Academy of Sciences. 102:9400-9405
α 1 -Adrenoceptor stimulation (α 1 ARS) modulates cardiac muscle contraction under physiological conditions by means of changes in Ca 2+ current through L-type channels (I Ca,L ) and Ca 2+ ensitivity of the myofilaments. However, the cellular mecha
Publikováno v:
Proceedings of the National Academy of Sciences. 102:7008-7013
We have investigated the ability of 5-methyltetrahydrofolate (5-MTHF) and tetrahydrobiopterin (BH 4 ) to modulate nitric oxide (NO)-independent vascular relaxations that are mediated by the sequential spread of endothelial hyperpolarization through t