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Autor:
Joachim W. Deitmer, Daniela Hirnet, Christian Lohr, Michael Doengi, Hans-Christian Pape, Philippe Coulon
Publikováno v:
Proceedings of the National Academy of Sciences. 106:17570-17575
We studied GABAergic signaling in astrocytes of olfactory bulb slices using confocal Ca 2+ imaging and two-photon Na + imaging. GABA evoked Ca 2+ transients in astrocytes that persisted in the presence of GABA A and GABA B receptor antagonists, but w
Publikováno v:
Proceedings of the National Academy of Sciences. 102:7008-7013
We have investigated the ability of 5-methyltetrahydrofolate (5-MTHF) and tetrahydrobiopterin (BH 4 ) to modulate nitric oxide (NO)-independent vascular relaxations that are mediated by the sequential spread of endothelial hyperpolarization through t
Publikováno v:
Proceedings of the National Academy of Sciences. 100:9733-9737
Renal vitamin D receptor (VDR) is required for 1,25-dihydroxyvitamin D 3 -[1,25(OH) 2 D 3 ]-induced renal reabsorption of calcium and for 1,25(OH) 2 D 3 -induced 1,25(OH) 2 D 3 24-hydroxylase. The long-term effect of vitamin D and dietary calcium on
Publikováno v:
Proceedings of the National Academy of Sciences. 95:8381-8386
The ciliary body contains an epithelial bilayer consisting of an outer pigmented cell layer (PE) and an inner nonpigmented cell layer (NPE) responsible for aqueous humor secretion. Secretion may be mediated in part by cytosolic Ca 2+ concentration ([
Publikováno v:
Proceedings of the National Academy of Sciences. 91:10232-10236
The human receptor Fc gamma RIIA for the Fc portion of IgG (Fc gamma) was expressed in a human T-cell line and conferred on these cells the ability to perform IgG antibody-stimulated phagocytosis. Crosslinking Fc gamma RIIA with anti-Fc gamma RII mon
Publikováno v:
Proceedings of the National Academy of Sciences. 89:10945-10949
Exposure of primary cultures of neonatal rat cortical astrocytes to bacterial lipopolysaccharide (LPS) results in the appearance of nitric oxide synthase (NOS) activity. The induction of NOS, which is blocked by actinomycin D, is directly related to
Autor:
Robert A. Good, Savita Pahwa, Hirosuke Yagura, Rajendra Pahwa, Naoki Oyaizu, Narendra Chirmule
Publikováno v:
Proceedings of the National Academy of Sciences. 89:8035-8039
The role of the CD4 molecule in activation of T-helper cells was examined by investigating the effect of an anti-CD4 monoclonal antibody (Leu3a) in conventional peptide antigen-specific cloned T-helper cells that are also reactive to staphylococcal e
Publikováno v:
Proceedings of the National Academy of Sciences. 89:7398-7402
Chromostatin is a 20-residue peptide derived from chromogranin A (CGA), the major soluble component of secretory granules in adrenal medullary chromaffin cells. One known biological function of chromostatin is to inhibit the secretagogue-evoked catec
Publikováno v:
Proceedings of the National Academy of Sciences. 88:5577-5581
The permeability of gap junctions in cultured striatal astrocytes was investigated by the scrape-loading/dyetransfer technique. Prolonged application of norepinephrine (NE) (10 microM) reduced by half the extent of dye (Lucifer yellow) spread. This e
Autor:
Yasuho Nishii, Yukio Kato, Masahiro Iwamoto, Kazuhisa Nakashima, Katsuhiko Sato, Fujio Suzuki, Tatsuya Koike, Atsushi Shimazu
Publikováno v:
Proceedings of the National Academy of Sciences. 87:6522-6526
The effects of vitamin D metabolites on alkaline phosphatase [ALPase; orthophosphoric-monoester phosphohydrolase (alkaline optimum), EC 3.1.3.1] activity, a marker of terminal differentiation, in chondrocyte cultures and growth plates in vivo were ex