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Autor:
Oleg Vsevolodovich Gerasimenko, Katsuhiko Mikoshiba, Ole H. Petersen, Etsuko Ebisui, Julia Vladimirovna Gerasimenko, Alexei V. Tepikin, Mark W. Sherwood, Gyorgy Lur
Publikováno v:
Proceedings of the National Academy of Sciences. 106:10758-10763
Toxic alcohol effects on pancreatic acinar cells, causing the often fatal human disease acute pancreatitis, are principally mediated by fatty acid ethyl esters (non-oxidative products of alcohol and fatty acids), emptying internal stores of Ca 2+ . T
Autor:
Lindsay S. Wilson, Donald H. Maurice, Hisham S. Elbatarny, Brian M. Bennett, Scott W. Crawley
Publikováno v:
Proceedings of the National Academy of Sciences. 105:13650-13655
It is generally accepted that nitric oxide (NO) donors, such as sodium nitroprusside (SNP), or phosphodiesterase 5 (PDE5) inhibitors, including sildenafil, each impact human platelet function. Although a strong correlation exists between the actions
Autor:
Miklós Sahin-Tóth, Richárd Szmola
Publikováno v:
Proceedings of the National Academy of Sciences. 104:11227-11232
Digestive trypsins undergo proteolytic breakdown during their transit in the human alimentary tract, which has been assumed to occur through trypsin-mediated cleavages, termed autolysis. Autolysis was also postulated to play a protective role against
Autor:
Robert A. Johnson, T. Bruce Ferguson, Sampath Parthasarathy, Mahesh S. Joshi, Jack R. Lancaster, Fruzsina K Johnson
Publikováno v:
Proceedings of the National Academy of Sciences. 104:9982-9987
Arginine contains the guanidinium group and thus has structural similarity to ligands of imidazoline and α-2 adrenoceptors (α-2 AR). Therefore, we investigated the possibility that exogenous arginine may act as a ligand for these receptors in human
Autor:
Satoshi Kurihara, Kimiaki Komukai, Hiroyuki Sasaki, Yoichiro Kusakari, Jin O-Uchi, Kenichi Hongo, Toru Obata
Publikováno v:
Proceedings of the National Academy of Sciences. 102:9400-9405
α 1 -Adrenoceptor stimulation (α 1 ARS) modulates cardiac muscle contraction under physiological conditions by means of changes in Ca 2+ current through L-type channels (I Ca,L ) and Ca 2+ ensitivity of the myofilaments. However, the cellular mecha
Publikováno v:
Proceedings of the National Academy of Sciences. 101:1840-1845
Glyceryl prostaglandins (PG-Gs) are generated by the oxygenation of the endocannabinoid, 2-arachidonylglycerol, by cyclooxygenase 2. The biological consequences of this selective oxygenation are uncertain because the cellular activities of PG-Gs have
Publikováno v:
Proceedings of the National Academy of Sciences. 89:7398-7402
Chromostatin is a 20-residue peptide derived from chromogranin A (CGA), the major soluble component of secretory granules in adrenal medullary chromaffin cells. One known biological function of chromostatin is to inhibit the secretagogue-evoked catec
Publikováno v:
Proceedings of the National Academy of Sciences. 88:5577-5581
The permeability of gap junctions in cultured striatal astrocytes was investigated by the scrape-loading/dyetransfer technique. Prolonged application of norepinephrine (NE) (10 microM) reduced by half the extent of dye (Lucifer yellow) spread. This e
Publikováno v:
Proceedings of the National Academy of Sciences. 71:2730-2733
A tetrapeptide, residues 6 to 9 in normal prothrombin, was isolated from the NH 2 -terminal, Ca 2+ -binding part of normal prothrombin. The electrophoretic mobility of the peptide was too high to be explained entirely by its amino-acid composition. A
Publikováno v:
Proceedings of the National Academy of Sciences. 74:4033-4036
When human 125I-labeled Factor Xa is incubated with washed platelets, prothrombin, and Ca2+, a small amount of thrombin is formed which causes the platelet release reaction after a period of time that decreases as the Xa concentration is increased fr