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Publikováno v:
Proc Natl Acad Sci U S A
Significance Fosfomycin is an antibiotic used for the treatment of cystitis. Its activity against both gram-positive and gram-negative pathogens has received strong recent interest. The compound is biosynthesized by both pseudomonads and streptomycet
Autor:
Jyoti Madhusoodanan
Publikováno v:
Proceedings of the National Academy of Sciences. 117:9135-9137
Millions of patients with Parkinson’s disease rely on the drug Levodopa for relief from tremors, slowed movement, and other motor symptoms. But many patients experience side effects such as cardiac arrhythmias, nausea, and gastrointestinal problems
Autor:
Rabindra K. Behera, Elizabeth C. Theil
Publikováno v:
Proceedings of the National Academy of Sciences. 111:7925-7930
Ferritin biominerals are protein-caged metabolic iron concentrates used for iron-protein cofactors and oxidant protection (Fe(2+) and O2 sequestration). Fe(2+) passage through ion channels in the protein cages, like membrane ion channels, required fo
Autor:
Concepción Palomo, Olga Cano, Mónica Herrero Vázquez, Vicente Mas, María C. Terrón, Margarita Magro, José A. Melero, Keith J. Chappell, Daniel Luque
Publikováno v:
Proceedings of the National Academy of Sciences. 109:3089-3094
Human respiratory syncytial virus (hRSV) is the most important viral agent of pediatric respiratory infections worldwide. The only specific treatment available today is a humanized monoclonal antibody (Palivizumab) directed against the F glycoprotein
Autor:
Kazuyuki Tatsumi, Norihiro Yamada, Yasuhiro Ohki, Kazuki Tanifuji, Tomoyuki Tajima, Motosuke Imada
Publikováno v:
Proceedings of the National Academy of Sciences. 108:12635-12640
The all-ferric [Fe 4 S 4 ] 4+ cluster [Fe 4 S 4 {N(SiMe 3 ) 2 } 4 ] 1 and its one-electron reduced form [ 1 ] - serve as convenient precursors for the synthesis of 3∶1-site differentiated [Fe 4 S 4 ] clusters and high-potential iron-sulfur protein
Publikováno v:
Proceedings of the National Academy of Sciences. 104:14478-14482
Endemic and epidemic shigellosis, an acute invasive disease of the lower intestines, afflicts millions of people worldwide with an estimated one million fatalities per annum at a low infectious dose. Our approach to vaccine development against Shigel
Autor:
Galina N. Nikolenko, Matthew J. Fivash, John M. Coffin, Frank Maldarelli, Vinay K. Pathak, Krista A. Delviks-Frankenberry, Sarah Palmer
Publikováno v:
Proceedings of the National Academy of Sciences. 104:317-322
We previously proposed that a balance between nucleotide excision and template RNA degradation plays an important role in nucleoside reverse transcriptase inhibitor (NRTI) resistance. To explore the predictions of this concept, we analyzed the role o
Publikováno v:
Proceedings of the National Academy of Sciences. 100:6394-6397
We have successfully used mutagenesis to engineer Taxol (paclitaxel) binding activity in Saccharomyces cerevisiae tubulin. Taxol, a successful antitumor agent, acts by promoting tubulin assembly and stabilizing microtubules. Several structurally dive
Publikováno v:
Proceedings of the National Academy of Sciences. 99:1212-1217
In the presence of phenylalanine, GTP cyclohydrolase I feedback regulatory protein (GFRP) forms a stimulatory 360-kDa complex with GTP cyclohydrolase I (GTPCHI), which is the rate-limiting enzyme in the biosynthesis of tetrahydrobiopterin. The crysta
The anticancer drug–DNA complex: Femtosecond primary dynamics for anthracycline antibiotics function
Publikováno v:
Proceedings of the National Academy of Sciences. 98:14212-14217
The anthracycline–DNA complex, which is a potent agent for cancer chemotherapy, has a unique intercalating molecular structure with preference to the GC bases of DNA, as shown by Rich's group in studies of single-crystal x-ray diffraction. Understa