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Publikováno v:
Proceedings of the National Academy of Sciences. 117:30699-30709
In recent years, the prevalence of carbapenem-resistant Enterobacteriaceae (CRE) has risen substantially, and the study of CRE resistance mechanisms has become increasingly important for antibiotic development. Although much research has focused on g
Autor:
Rolf Müller, Robert Landick, Mirjana Lilic, Jennifer Herrmann, Rachel A. Mooney, Hande Boyaci, Elizabeth A. Campbell, Nathaniel Braffman, James Chen, Seth A. Darst, Elizabeth A. Hubin
Publikováno v:
Proceedings of the National Academy of Sciences. 117:30423-30432
Rifampicin (Rif) is a first-line therapeutic used to treat the infectious disease tuberculosis (TB), which is caused by the pathogen Mycobacterium tuberculosis (Mtb). The emergence of Rif-resistant (RifR) Mtb presents a need for new antibiotics. Rif
Autor:
Michael A. Ochsenkühn, Kristin C. Gunsalus, Miraflor P. Santos, Ahmed A. Shibl, Ashley Isaac, Gregory Behringer, Shady A. Amin, Cong Fei, Marc Arnoux, Christian R. Voolstra, Anny Cárdenas, Nizar Drou
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Significance Phytoplankton are major primary producers in the marine environment that excrete a wide range of metabolites. These exudates support the growth of surrounding bacteria that in turn provide phytoplankton cells with resources and growth co
Publikováno v:
Proc Natl Acad Sci U S A
Melatonin (Mel) promotes sleep through G protein-coupled receptors. However, the downstream molecular target(s) is unknown. We identified the Caenorhabditis elegans BK channel SLO-1 as a molecular target of the Mel receptor PCDR-1-. Knockout of pcdr-
Autor:
Randall T. Hayden, Jose Ferrolino, Daniel R. Evans, Daria Van Tyne, Jason W. Rosch, Joshua Wolf, Anh N. Vo, Gabriela Maron, Gayatri Shankar Chilambi, Michael S. Gilmore, Hayley R. Nordstrom
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Significance Immunocompromised patients are at increased risk for multidrug-resistant infections, due to broad-spectrum antibiotic exposure and a host environment with limited innate defenses. This study explored how vancomycin-resistant Enterococcus
Autor:
Philipp Olias, Qiuling Wang, Eugene Park, Wayne M. Yokoyama, Zhou Huang, L. David Sibley, Sumit K. Matta
Publikováno v:
Proceedings of the National Academy of Sciences. 116:17480-17491
In contrast to the importance of type II interferon-γ (IFN-γ) in control of toxoplasmosis, the role of type I IFN is less clear. We demonstrate here that TgIST, a secreted effector previously implicated in blocking type II IFN-γ signaling, also bl
Autor:
Elizabeth S. Sattely, Ramesha B. Thimmappa, Anne Osbourn, Hannah E. Hodgson, Jason Leigh Vincent, Michael J. Stephenson, Ricardo De La Peña
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Significance Limonoids are natural products made by members of the Meliaceae and Rutaceae families. Some limonoids (e.g., azadirachtin) are toxic to insects yet harmless to mammals. The use of limonoids in crop protection and other applications curre
Autor:
Jyoti Madhusoodanan
Publikováno v:
Proceedings of the National Academy of Sciences. 117:9135-9137
Millions of patients with Parkinson’s disease rely on the drug Levodopa for relief from tremors, slowed movement, and other motor symptoms. But many patients experience side effects such as cardiac arrhythmias, nausea, and gastrointestinal problems
Publikováno v:
Proceedings of the National Academy of Sciences. 116:5499-5504
Fungi have the potential to produce a large repertoire of bioactive molecules, many of which can affect the growth and development of plants. Genomic survey of sequenced biofertilizer fungi showed many secondary metabolite gene clusters are anchored
Autor:
Chanaki Amaratunga, John H. Adams, Carole A. Long, Kenneth O. Udenze, Sarah R. Kaslow, Juliana M. Sá, Rebecca E. Salzman, Robert W. Gwadz, Paul K. J. Han, Kazutoyo Miura, J. Patrick Mershon, Jianbing Mu, Rick M. Fairhurst, Christine E. Figan, Richard T. Eastman, Marvin L. Thomas, Xin-zhuan Su, Kimberly F Breglio, Ramoncito L. Caleon, Suzanne Li, Ababacar Diouf, Sumana Chakravarty, Nina F. Gnädig, Min Zhang, Eric R. James, Stacy M. Ricklefs, Michael P. Fay, Viviana A. Melendez-Muniz, Stephen L. Hoffman, Whitney A. Kite, David A. Fidock, Bingbing Deng, Roberto R. Moraes Barros, Gregory Tullo, Anna Liu, B. Kim Lee Sim, Daniel E. Sturdevant, Thomas E. Wellems, Tyler J. Gibson, Michael Krause, Rifat S. Rahman, Soundarapandian Velmurugan, Erika P. Nishiguchi, Stephen F. Porcella, Judith Straimer, Theresa Engels
Publikováno v:
Proceedings of the National Academy of Sciences. 115:12513-12518
Concerns about malaria parasite resistance to treatment with artemisinin drugs (ARTs) have grown with findings of prolonged parasite clearance t1/2s (>5 h) and their association with mutations in Plasmodium falciparum Kelch-propeller protein K13. Her